Thousands Who Got COVID-19 in March Are Still Sick

COVID-19 has existed for less than six months, and it is easy to forget how little we know about it. The standard view is that a minority of infected people, who are typically elderly or have preexisting health problems,... read more

COVID-19 Patients with ARDS Face Significant Financial Effects in Recovery

Long hospitalizations lead to large medical bills, with serious physical and emotional consequences for those recovering from critical illness. It begins with shortness of breath. And for approximately one-third of patients,... read more

WHO Resumes Hydroxychloroquine Study for COVID-19

The World Health Organization is resuming a clinical trial exploring whether the malaria drug hydroxychloroquine can effectively treat COVID-19, after pausing enrollment in the study to review safety concerns about the drug. The... read more

The Perils of Premature Phenotyping in COVID-19

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) poses an unprecedented global healthcare challenge. Severe novel Coronavirus disease (COVID-19) pneumonia frequently causes hypoxemic respiratory failure, manifesting... read more

Blood Vessel Attack Could Trigger Coronavirus’ Fatal Second Phase

Frank Ruschitzka told his pathologist to be ready before the first COVID-19 patient died. In early March, Ruschitzka, who leads the cardiology department at University Hospital Zürich, noticed that patients with the disease... read more

What’s Next for EDs in the COVID-19 Pandemic?

As of late May, most countries have falling numbers of new cases of COVID-19 and are at various stages of easing lockdown orders. This seems a good time to look back on the pandemic experience so far and at what lessons we... read more

What COVID-19 Has Taught Me

A personal narrative of Adrian Wong’s experience while battling COVID-19 at King's College Hospital. These are the author's personal opinions and do not represent the views of the institution and professional societies... read more

Corticosteroids for Critically Ill COVID-19 Patients with Cytokine Release Syndrome

Approximately 5% of coronavirus disease (COVID-19) patients will require admission to an intensive care unit (ICU). Among these patients, the most severe cases may be mediated by a late-onset systemic inflammatory response... read more

Prolonged Prone Position Ventilation for SARS-CoV-2 Patients is Feasible and Effective

Recently, novel coronavirus 2019 (nCOV-19) is spreading all around the world causing severe acute respiratory syndrome (SARS-CoV-2) requiring mechanical ventilation in about 5% of infected people. Prone position ventilation... read more

Predictors of Care in Persons Under Investigation for COVID-19

The healthcare burden of the coronavirus disease 2019 (COVID-19) pandemic extends beyond patients who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a retrospective cohort study... read more

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more

Urge Congress to Ensure that Emergency Physicians Have Due Process Rights

H.R. 6910, critical bipartisan legislation to ensure every emergency physician has medical staff due process rights was recently introduced by emergency physician and member of Congress, Rep. Raul Ruiz, MD (D-CA), and Rep.... read more

ICU Isolation Hood Decreases Risk of Aerosolization During Noninvasive Ventilation with COVID-19

The treatment of patients with coronavirus disease (COVID-19) needs to take into consideration not only the disease process but also the availability of medical resources and the risks of transmission to healthcare providers.... read more

Spontaneous Echo Contrast in Venous Ultrasound of Severe COVID-19 Patients

Initial reports have indicated a higher incidence of venous thromboembolism (VTE) among patients with coronavirus disease 2019 (COVID-19) compared to other critical illnesses. Helms et al. found pulmonary embolisms in 25%... read more

Is Locoregional Anesthesia a Functional Option for Major Abdominal Surgeries in the COVID-19 Era?

Based on our preliminary case series, awake open surgery has resulted feasible and safe. This approach has allowed to perform undelayable major abdominal surgeries on fragile patients when intensive care beds were not available.... read more

International PICU COVID-19 Collaboration Conference Call

This episode is an international collaborative conference call hosted by Dr. Jeffrey Burns of Boston Children's Hospital and Harvard Medical School. Featured speakers are Drs. Daniel Barouch, Trevor Duke, and Robinder Khemani,... read more

First Report on a First-in-Human Clinical Trial of a Novel Ad5 Vectored COVID-19 Vaccine

This is the first report on a first-in-human clinical trial of a novel Ad5 vectored COVID-19 vaccine. The Ad5 vectored COVID-19 vaccine was tolerated in healthy adults in all three dose groups. The most common adverse... read more

RAAS Inhibitors and Risk of COVID-19

The authors concluded that RAAS inhibitors do not increase the risk of COVID-19 requiring admission to the hospital, including fatal cases and those admitted to intensive care units (ICUs), and should not be discontinued... read more

Prevention of Pathogen Transmission During Ultrasound Use in the ICU

The Australasian Society for Ultrasound in Medicine (ASUM) and the Australasian College for Infection Prevention Control (ACIPC) published guidelines on minimum standards for reprocessing/cleaning of ultrasound transducers... read more

Simulated COVID-19 Contamination of Health Care Workers After Endotracheal Intubation of Manikins

Despite personal protective equipment, fluorescent markers were found on the uncovered skin, hair, and shoes of participants after simulations of emergency department management of patients experiencing respiratory distress.... read more

Blood Thinners May Improve Survival Among Hospitalized COVID-19 Patients

Treating hospitalized COVID-19 patients with anticoagulants--blood thinners that slow down clotting--may improve their chances of survival, researchers from the Mount Sinai COVID Informatics Center report. The study,... read more

Clinical Distancing of Patients with Advanced Heart Failure and Cardiac Transplantation During COVID-19

Our hospital system includes a central 825-bed, short term, acute care teaching facility where heart transplantation is performed under regulatory approval. Located 5.5 miles north of this main campus is a 107-bed cardiac... read more