Tag: delirium
Zosyn vs. Efepime: Which One Is Safer?
While both piperacillin-tazobactam and cefepime are commonly used to treat infections caused by Pseudomonas aeruginosa in hospitalized patients, there is a concern that piperacillin-tazobactam may lead to acute kidney injury... read more
Awake Veno-Venous ECMO in ICU
Extracorporeal membrane oxygenation (ECMO) is an advanced treatment for severe respiratory failure. Implantation of ECMO before invasive ventilation or extubation during ECMO has been reported and is becoming increasingly... read more
Weaning Sedation in Pediatric Intensive Care
The use of sedation and analgesia to provide comfort, safety, and pain treatment are central principles in the care of critically ill children. Most critically ill children are at risk of experiencing pain and discomfort... read more
Management of Pain, Anxiety, and Delirium in Critically Injured Pediatric Trauma Patients
PICU-specific care bundles have been beneficial in standardizing the assessment, prevention and treatment of pain, anxiety and delirium. While these practices show promise in addressing current management challenges in... read more
Awake, Walking, and Intubated – The ICU Breakthrough Giving Patients Their Lives Back
If they knew what it's like for patients surviving after the ICU, that sedation isn't sleep, and that they're being so traumatized and damaged by these normal practices, they would change this. Picture this: it's your... read more
Effects of Surgery on Hemodynamics and Postoperative Delirium in Stanford Type A Aortic Dissection
The results of this study indicate that surgical intervention has a significant effect on improving patients’ hemodynamic parameters, with postoperative MAAD and LVEDd reduced compared to preoperative levels, while LVEF... read more
Delirium and Weakness Acquired in the ICU: Individual and Combined Effects on 90-Day Mortality in Survivors of Critical Illness
Mortality is substantially high among critically ill survivors who experience both delirium and weakness, although no additive effect on mortality was observed when these conditions occur together. Our findings highlight... read more
How to end quiet suffering in the ICU? Identifying and treating hypoactive delirium
The duration of time a person spends in hypoactive delirium predicts higher rates of death, longer length of stay, higher costs of care, and higher rates of acquired dementia in the months and years following critical illness.... read more
Risk Factors for Mortality in Patients with Sepsis or Sepsis-associated Delirium Based on the MIMIC-IV Database
Research on the severity and prognosis of sepsis with or without progressive delirium is relatively insufficient. We constructed a prediction model of the risk factors for 28-day mortality in patients who developed sepsis... read more
Haloperidol vs. Placebo in ICU Patients with Delirium
We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. In acutely admitted adult ICU patients with delirium, haloperidol treatment... read more
Haloperidol Efficacy to Decrease Delirium Burden in Critically Ill Patients
This trial, that was stopped early, did not show evidence that haloperidol reduces delirium and coma in critically ill patients with delirium. The beneficial effects on some agitation-related outcomes and lower sedative... read more
Delirium Treatment with Haloperidol Not Associated with Higher Risk of QTc-interval Prolongation
Delirium treatment with haloperidol and/or pipamperone was not associated with a higher risk of QTc-interval prolongation in this naturalistic patient sample but was greater in magnitude and correlated with equipotent dosage... read more
Haloperidol and Delirium: What is Next?
Haloperidol is, by far, the best-studied antipsychotic in ICU, appears to be safe in the dosing range used in these two trials and is easy to administer and titrate. For these reasons, if a clinician chooses to pharmacologically... read more
Delirium in Critically Ill Patients – Haloperidol Treatment
Haloperidol may reduce mortality and likely result in little to no change in the occurrence of SAEs/SARs compared with placebo in critically ill patients with delirium. However, the results were not statistically significant... read more
ICU Delirium – A Decade of Learning
Think of delirium as the phenotypic manifestation of global, acute brain dysfunction that can deprive patients of their dignity. This syndrome of acute changes in awareness, attention, and cognition is an independent... read more
Significant Persistent Pain Symptoms After Critical Care Illness
Persistent pain could be a common health problem after critical illness care. Our data also suggest that there is a lack of specific follow-up after ICU discharge. Given the major consequences on patient quality of life,... read more
Haloperidol vs. Placebo for Delirium Treatment in ICU Patients
We found high probabilities of benefits and low probabilities of harm with haloperidol treatment compared with placebo in acutely admitted, adult ICU patients with delirium for the primary and most secondary outcomes. The... read more
Multifaceted Early Mobility Intervention Impact for Critically Ill Children
This study will examine whether a multifaceted strategy to optimize early mobility affects the duration of mechanical ventilation, delirium incidence, and functional outcomes in critically ill children. This study will... read more
Delirium Prevention in the ICU: Melatonin or Ramelteon
Melatonin modulates the circadian rhythm and has been studied as a preventive measure against the development of delirium in hospitalized patients. Such an effect may be more evident in patients admitted to the ICU, but findings... read more
