New Hope for Concussions TBI & PTSD

Dr. Larry Komer and Joan Chandler Komer offer new hope to those with brain injuries. Millions of people of all ages experience concussions. Many others have a more serious event known as a traumatic brain injury. Battlefield... read more

New Hope for Concussions TBI & PTSD

Delirium is Prevalent in Older Hospital Inpatients and Associated with Adverse Outcomes

Delirium is prevalent in older adults in UK hospitals but remains under-recognised. Frailty is strongly associated with the development of delirium, but delirium is less likely to be recognised in frail patients. The... read more

Nonconvulsive Status Epilepticus: Overlooked and Undertreated

Nonconvulsive status epilepticus (NCSE) is characterized by persistent change in mental status from baseline lasting more than 5 minutes, generally with epileptiform activity seen on EEG monitoring and subtle or no motor... read more

Practical Trends in Anesthesia and Intensive Care 2018

This book offers an essential guide to managing the most-debated hot topics of practical interest in anesthesia and intensive care. It reviews the state of the art in issues concerning both intensive care medicine and anesthesia,... read more

Practical Trends in Anesthesia and Intensive Care 2018

Left Ventricular Wall Findings in Non-electrocardiography-gated CE-CT After ECPR

Few studies have reported left ventricular wall findings in contrast-enhanced computed tomography (CE-CT) after extracorporeal cardiopulmonary resuscitation (ECPR). This study examined left ventricular wall CE-CT findings... read more

Epidemiology and Costs of Sepsis in the United States

The highest burden of incidence and total costs occurred in the lowest severity sepsis cohort population. Sepsis cases not diagnosed until after admission, and those with increasing severity had a higher economic burden and... read more

Urgent Intubation without Neuromuscular Blocking Agents and the Risk of Tracheostomy

Neuromuscular blocking agents play a significant role in improving the success rate for urgent intubation, although there is limited evidence about the effect on subsequent outcomes, such as the incidence of tracheostomy.... read more

Idiopathic Intracranial Hypertension

A 22 year-old female with a medical history of migraines and obesity who presents to the Emergency Department with a headache. Her headache was gradual in onset, but has progressively worsened and has not been relieved... read more

Diagnosis of Nonventilated Hospital-acquired Pneumonia

Nonventilated hospital-acquired pneumonia (NV-HAP) poses several barriers for diagnosis compared with VAP, and the available knowledge is limited. A call for further research in diagnosis of nonventilated HAP is urgent.... read more

Neonatal Early-Onset Sepsis Evaluation

Twelve years ago, we began a National Institutes of Health–funded study of neonatal early-onset sepsis (EOS) whose goal was to develop multivariate predictive models that could be used by clinicians to evaluate a newborn’s... read more

Hydration for Infants with Bronchiolitis

Bronchiolitis is the most common lower respiratory tract infection in infants and the leading cause of hospital admission. Hydration is a mainstay of treatment, but insufficient evidence exists to guide clinical practice.... read more

Biomarker Profiles of Coagulopathy and Alveolar Epithelial Injury in ARDS

Coagulopathy and alveolar epithelial injury were observed in both patients with direct common risk factors (dARDS) and with idiopathic or immune-related diseases (iARDS). However, their biomarker profiles were significantly... read more

What should we stop doing in the ICU?

Intensive care is an interesting specialty. From all the early excitement in the 1970s, passing through two decades of intensive physiological use at the bedside, intensive care landed on the rough ground of modern randomized... read more

Abdominal Compartment Syndrome

Abdominal compartment syndrome (ACS) is defined by sustained intra-abdominal pressure (IAP) > 20 mm Hg with associated organ injury. The condition was first described in 1863, but not significantly discussed until the 1990s.... read more

Clustering Algorithms Usage in Critical Care Research Unravel Patient Heterogeneity

Critically ill patients constitute the most heterogeneous population in the hospital, with the highest rates of acute and chronic multi-morbidity. Daily, two critically ill patients are admitted to the ICU with the same... read more

The Hospitalist Role in Treating Opioid Use Disorder

Opioid use disorder, like many of the other conditions we see, is a chronic relapsing remitting medical disease and a risk factor for premature mortality. When a patient with diabetes is admitted with cellulitis, we might... read more

Manual of Traumatic Brain Injury: Assessment and Management

Now completely revised and updated, Manual of Traumatic Brain Injury: Assessment and Management, Second Edition is a comprehensive evidence-based guide to brain injury diagnosis, treatment, and recovery, delivered in a succinct... read more

Manual of Traumatic Brain Injury: Assessment and Management

Perioperative Kidney Injury: Principles of Risk Assessment, Diagnosis and Treatment

The kidneys participate in all vital processes of the body to maintain overall homeostasis and health. When kidneys are injured during surgical interventions, metabolic and hemodynamic control is disrupted, leading to dysfunction... read more

Perioperative Kidney Injury: Principles of Risk Assessment, Diagnosis and Treatment

Antibiotics for Sepsis

Antibiotics for Sepsis - Does Each Hour Really Count? Or is it Incestuous Amplification? - by Prof Mervyn Singer "Each hour's delay in initiating antibiotics costs lives" is a doctrine that has attained quasi religious status.... read more

Early Prediction of Prognosis in Elderly Acute Stroke Patients

Acute stroke has a high morbidity and mortality in elderly population. Baseline confounding illnesses, initial clinical examination, and basic laboratory tests may impact prognostics. In this study, we aimed to establish... read more

In-hospital Mortality Associated with the Misdiagnosis or Unidentified Site of Infection at Admission

Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aimed to investigate... read more

Unaccountable: What Hospitals Won’t Tell You and How Transparency Can Revolutionize Health Care

Dr. Marty Makary is co-developer of the life-saving checklist outlined in Atul Gawande's bestseller The Checklist Manifesto. A Johns Hopkins surgeon and professor of public health, he can testify to the amazing power of modern... read more

Unaccountable: What Hospitals Won’t Tell You and How Transparency Can Revolutionize Health Care