Vitamin Treatment For Sepsis Is Put To The Test

Vitamin Treatment For Sepsis Is Put To The Test

Dr. Jonathan Sevransky was intrigued when he heard that a well-known physician in Virginia had reported remarkable results from a simple treatment for sepsis. Could the leading cause of death in hospitals really be treated... read more

pH-guided Fluid Resuscitation and BICAR-ICU

pH-guided Fluid Resuscitation and BICAR-ICU

The use of bicarbonate is a source of eternal disagreement. Bicarbonate has a shameful history of being abused in situations where it's unhelpful (e.g. cardiac arrest). This has impugned its reputation, giving it an aura... read more

Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis

Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis

The aim of the study was to describe the population pharmacokinetics (PK) of meropenem in critically ill patients receiving sustained low-efficiency dialysis (SLED). We found a relevant PK variability for meropenem in patients... read more

Is Intravenous Administration of Iodixanol Associated with Increased Risk of AKI, Dialysis, or Mortality?

Is Intravenous Administration of Iodixanol Associated with Increased Risk of AKI, Dialysis, or Mortality?

Among patients at the highest perceived risk of post-contrast Acute Kidney Injury (AKI), intravenous administration of iodixanol for contrast material enhanced CT was not an independent risk factor for AKI, dialysis, or... read more

Persistent Gaps in Use of Advance Directives Among Nursing Home Residents Receiving Maintenance Dialysis

Persistent Gaps in Use of Advance Directives Among Nursing Home Residents Receiving Maintenance Dialysis

Patients with end-stage renal disease receiving dialysis have a symptom burden and prognosis comparable to patients with incurable cancer. They frequently and increasingly receive intensive procedures near the end of life.... read more

Acute Kidney Injury is not Associated with IV Contrast Use in the ED

Acute Kidney Injury is not Associated with IV Contrast Use in the ED

Intravenous (IV) iodinated contrast media is used routinely to improve the accuracy of computed tomography (CT) in the emergency department (ED).  Prior studies have linked contrast media with the development of acute kidney... read more

Clinical practice guideline on diagnosis and treatment of hyponatraemia

Clinical practice guideline on diagnosis and treatment of hyponatraemia

Hyponatraemia, defined as a serum sodium concentration <135 mmol/l, is the most common disorder of body fluid and electrolyte balance encountered in clinical practice. It can lead to a wide spectrum of clinical symptoms,... read more

Culture-Negative Severe Sepsis: Nationwide Trends and Outcomes

Culture-Negative Severe Sepsis: Nationwide Trends and Outcomes

CNSS among hospitalized patients is common, and its proportion is on the rise. CNSS is associated with greater acute organ dysfunction and mortality. Having CNSS is an independent predictor of death. Of 6,843,279 admissions... read more

Hemodialysis Patients who skipped influenza vaccine more likely to be hospitalized

Hemodialysis Patients who skipped influenza vaccine more likely to be hospitalized

Hemodialysis patients who skipped vaccination were 53% more likely to be hospitalized during the flu season the first year, 87% more likely to be hospitalized the second year, and 158% more likely to be hospitalized the third... read more

Is it possible to reduce hospital admissions through evidence-based clinic staffing?

Is it possible to reduce hospital admissions through evidence-based clinic staffing?

Patients who find themselves on in-center dialysis have the higher rates of hospital admissions than those on peritoneal dialysis. These admissions represent a significant financial cost and account for approximately 40%... read more