The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19

The Use of ECMO in Patients with Cardiopulmonary Failure Due to COVID-19

COVID-19 related cardiopulmonary failure such as ARDS and cardiogenic shock or massive pulmonary embolism can be successfully supported with ECMO. Judicious patient selection is important to enable maximal benefit and optimized... read more

Massive PE with Intra-hospital Cardiac Arrest and Full Recovery of RV Function after vaECMO

Massive PE with Intra-hospital Cardiac Arrest and Full Recovery of RV Function after vaECMO

The concept of vaECMO treatment alone might be a valuable alternative in selected patients with massive PE and cardiogenic shock, in whom thrombolytic therapy might not unload the RV fast enough. We present a case of a... read more

Surgery of the Inferior Vena Cava

Surgery of the Inferior Vena Cava

This book addresses an urgent need, offering an updated, detailed and multidisciplinary review of surgery of the inferior vena cava (IVC). Over the past two decades, tremendous advances have been made in this field and related... read more

High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection

High Risk of Thrombosis in Patients With Severe SARS-CoV-2 Infection

Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore... read more

From despair to hope: advanced therapy gives a lifeline to the sickest COVID-19 patients

From despair to hope: advanced therapy gives a lifeline to the sickest COVID-19 patients

More than two months later, that piece of paper still lies on her coffee table with four letters on it: "E-C-M-O." Irena Veronese had never heard that acronym before, but when it was first mentioned to her, it meant moving... read more

Clinical Experience of Whole-body CT as the Initial Evaluation Tool After ECPR in OHCA Patients

Clinical Experience of Whole-body CT as the Initial Evaluation Tool After ECPR in OHCA Patients

Routine whole-body computed tomography (CT) after extracorporeal cardiopulmonary resuscitation (ECPR) in out-of-hospital cardiac arrest (OHCA) patients appears to have a limited role, as the majority is caused by ACS. However,... read more

How I Approach Weaning from Venoarterial ECMO

How I Approach Weaning from Venoarterial ECMO

Weaning from VA-ECMO remains a challenging but critically important step in device management. The key is to balance minimizing complications associated with device support with the potential for hemodynamic deterioration... read more

Spotting the Clotting: Hypercoagulopathy in COVID-19

Spotting the Clotting: Hypercoagulopathy in COVID-19

Evolving experience with TEG, clotting parameters, treatment considerations, and ongoing data gathering will help us better understand if antiplatelet therapy with aspirin or clopidogrel or anticoagulant treatment with traditional... read more

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Remdesivir 5-day vs. 10-day Trial Raises Some Red Flags?

Gilead's first Randomized Controlled Trial on remdesivir was just published, and it's very interesting. This is a trial designed, monitored, and written by Gilead. In some ways, the design of the trial and its missing parts... read more

Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation

Long-Term Health-Related Quality of Life After Venovenous Extracorporeal Membrane Oxygenation

This study examined the long-term health-related quality of life in adult patients treated with venovenous extracorporeal membrane oxygenation (V-V ECMO) for severe acute respiratory failure in Ireland. A retrospective, cross-sectional... read more

Unfractionated Heparin (UFH), LMWH, Fondaparinux, Argatroban, and Bivalirudin

Unfractionated Heparin (UFH), LMWH, Fondaparinux, Argatroban, and Bivalirudin

Unfractionated heparin (UFH) binds to anti-thrombin III (AT-III), which enhances antithrombin's inhibition of several coagulation factors – especially factor Xa and factor IIa (thrombin). Low Molecular-Weight Heparin... read more

Sharing Data is the Key to Unlocking Remdesivir Challenges

Sharing Data is the Key to Unlocking Remdesivir Challenges

Critical care teams should consider using remdesivir to treat patients with severe acute SARS-CoV-2 infection, but supply of the drug is limited and best practices for maximizing its effectiveness are not completely understood. The... read more

Global Effort to Collect Data on Ventilated Patients With COVID-19

Global Effort to Collect Data on Ventilated Patients With COVID-19

As the new chair of the Asia-Pacific Chapter of the Extracorporeal Life Support Organization (ELSO), John Fraser, MBChB, PhD, began talking with the group's members last November about why influenza affects some people worse... read more

Nationwide System to Centralize Decisions Around ECMO Use for Severe COVID-19 Pneumonia in Japan

Nationwide System to Centralize Decisions Around ECMO Use for Severe COVID-19 Pneumonia in Japan

The novel coronavirus disease 2019 (COVID-19) is spreading in Japan. The number of patients who need extracorporeal membrane oxygenation (ECMO) is expected to increase; however, the clinical characteristics of the patients... read more

How I Manage Drainage Insufficiency on ECMO

How I Manage Drainage Insufficiency on ECMO

As the use of extracorporeal membrane oxygenation (ECMO) expands, a systematic approach to the management of complex technical issues, such as drainage insufficiency, is essential to improving patient outcomes. Due to... read more

An Interview With an Italian Intensivist on the COVID Experience in Italy

An Interview With an Italian Intensivist on the COVID Experience in Italy

The current COVID-19 crisis has a huge human impact. Clearly cardiovascular issues have a central role in management and, unfortunately, in adverse outcomes. We are continually struggling to understand risks and management... read more

ARDS Diagnosis May Be Underrecognized

ARDS Diagnosis May Be Underrecognized

The February 27, 2020 Department of Internal Medicine Medical Grand Rounds "Acute Respiratory Distress Syndrome (ARDS),” was presented by Marc Moss, MD, Roger S. Mitchell Professor of Medicine; head, Division of Pulmonary... read more