Epidemiology and Changes in Mortality of Sepsis After the Implementation of Surviving Sepsis Campaign Guidelines

This is a prospective, multicenter, observational study performed during a 5-month period in 2011 in a network of 11 intensive care units (ICUs). We compared our findings with those obtained in the same ICUs in a study conducted... read more

Epidemiology and Changes in Mortality of Sepsis After the Implementation of Surviving Sepsis Campaign Guidelines

New Guideline Aids in Diagnosing Idiopathic Pulmonary Fibrosis

A new international guideline has been developed to help physicians diagnosis idiopathic pulmonary fibrosis (IPF), a rare and often fatal lung disease whose cause is unknown. IPF is the most common and deadly form of a group... read more

New Guideline Aids in Diagnosing Idiopathic Pulmonary Fibrosis

Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation

Among patients with severe secondary mitral regurgitation, the rate of death or unplanned hospitalization for heart failure at 1 year did not differ significantly between patients who underwent percutaneous mitral-valve repair... read more

Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation

Diagnosis and Treatment of Clostridium difficile Infection

Clostridium difficile infection (CDI) is less common than antibiotic-associated diarrhea and irritable bowel syndrome. There is significant concern about overdiagnosis and subsequent overtreatment of CDI with increasing use... read more

Diagnosis and Treatment of Clostridium difficile Infection

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

In patients with endocarditis on the left side of the heart who were in stable condition, changing to oral antibiotic treatment was noninferior to continued intravenous antibiotic treatment. After randomization, antibiotic... read more

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Under the auspices of the Society of Critical Care Medicine, this executive summary aims to provide the most clinically meaningful and novel aspects, by section, of the PADIS guidelines that clinicians, stakeholders, and... read more

Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Chest Compression Rates and Pediatric In-hospital Cardiac Arrest Survival Outcomes

Non-compliance with compression rate Guidelines was common in this multicenter cohort. Among ICU patients, slightly lower rates were associated with improved outcomes compared to Guidelines.Prospective observational study... read more

Chest Compression Rates and Pediatric In-hospital Cardiac Arrest Survival Outcomes

Ranking antibiotics in order of allergenicity

Our current approach to allergy is primarily patient-based. This focuses on the patient’s prior history of reaction: how severe was it, when was it, how certain are we that it was truly allergic? This strategy has been... read more

Ranking antibiotics in order of allergenicity

Methodologic Innovation in Creating Clinical Practice Guidelines

Our multifaceted, interdisciplinary approach and novel methodologic strategies can help inform the development of future critical care clinical practice guidelines. Critical illness survivors contributed to prioritizing topics,... read more

Methodologic Innovation in Creating Clinical Practice Guidelines

Intracranial Pressure Thresholds in Severe Traumatic Brain Injury: Pro

Teleologically, the mammalian brain has evolved to be the central component of life. It coordinates afferent and efferent neural pathways, integrates neurohormonal responses and, in humans, produces higher cortical effects... read more

Intracranial Pressure Thresholds in Severe Traumatic Brain Injury: Pro

The Checklist Manifesto: How to Get Things Right

We train longer, specialize more, use ever-advancing technologies, and still we fail. Atul Gawande makes a compelling argument that we can do better, using the simplest of methods: the checklist. In riveting stories, he reveals... read more

The Checklist Manifesto: How to Get Things Right

Treatment of Acute Non-Anion Gap Metabolic Acidosis

Acute non-anion gap metabolic acidosis is now recognized to be as a common cause of metabolic acidosis, particularly in the ICU. Further examination of its impact on cellular function and clinical outcome are needed. Most... read more

Treatment of Acute Non-Anion Gap Metabolic Acidosis

Guidelines for the Management of Tracheal Intubation in Critically Ill Adults

These guidelines describe a comprehensive strategy to optimize oxygenation, airway management, and tracheal intubation in critically ill patients, in all hospital locations. They are a direct response to the 4th National... read more

Guidelines for the Management of Tracheal Intubation in Critically Ill Adults

Predictors of In-Hospital Mortality After RRT Calls

Despite wide adoption of rapid response teams across the United States, predictors of in-hospital mortality for patients receiving rapid response team calls are poorly characterized. Identification of patients at high risk... read more

Predictors of In-Hospital Mortality After RRT Calls

Very high intact-protein formula successfully provides protein intake according to nutritional recommendations in overweight critically ill patients

Enteral feeding with VHPF (8 g/100 kcal) resulted in higher protein intake and plasma amino acid concentrations than an isocaloric SHPF (5 g/100 kcal), without an increase in energy intake. This VHPF facilitates feeding according... read more

Very high intact-protein formula successfully provides protein intake according to nutritional recommendations in overweight critically ill patients

Sepsis Guidelines Spark EM Petition

It took all of one day for emergency physicians to organize opposition after an update to the Surviving Sepsis Campaign Bundle was released online. The day after the new version was released, Scott D. Weingart, MD, the editor-in-chief... read more

Sepsis Guidelines Spark EM Petition

The Relationship Between ICU Hypotension and In-hospital Mortality and Morbidity in Septic Patients

Current guidelines recommend maintaining a mean arterial pressure (MAP)≥ 65 mmHg in septic patients. However, the relationship between hypotension and major complications in septic patients remains unclear. We, therefore,... read more

The Relationship Between ICU Hypotension and In-hospital Mortality and Morbidity in Septic Patients

Sepsis patients treated and released from emergency departments do well with outpatient follow-up

National guidelines assume that all patients who're diagnosed with clinical sepsis in an emergency department will be admitted to the hospital for additional care, but new research has found that many more patients are being... read more

Sepsis patients treated and released from emergency departments do well with outpatient follow-up