Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence... read more

Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children

Artificial Intelligence or Merely a Symptom of a Broken Healthcare System?

We are constantly hunting for newer and better sources of information. This leads to a perpetual generation of newer lab tests, different hemodynamic gizmos, and fresh decision tools. Some of these pan out. Most don't. Why... read more

Artificial Intelligence or Merely a Symptom of a Broken Healthcare System?

Microcirculation Evolution in Patients on VA-ECMO for Refractory Cardiogenic Shock

Microcirculation is severely impaired in patients with refractory cardiogenic shock requiring venoarterial extracorporeal membrane oxygenation (VA-ECMO). Inability to rapidly restore microcirculation during the first... read more

Microcirculation Evolution in Patients on VA-ECMO for Refractory Cardiogenic Shock

Vasopressin for Acute Hemorrhage?

Vasoactive medications are one of the pillars of management of shock in Emergency Departments. Inopressors, namely Norepinephrine and Epinephrine, are the two most commonly used pressors in US Emergency Departments, used... read more

Vasopressin for Acute Hemorrhage?

Predicting Adverse Hemodynamic Events in Critically Ill Patients

The art of predicting future hemodynamic instability in the critically ill has rapidly become a science with the advent of advanced analytical processed based on computer-driven machine learning techniques. How these... read more

Predicting Adverse Hemodynamic Events in Critically Ill Patients

The Neurohormonal Basis of Pulmonary Hypertension in HFpEF

Subjects with heart failure with preserved ejection fraction (HFpEF) display activation of the endothelin and adrenomedullin neurohormonal pathways, the magnitude of which is associated with pulmonary hemodynamic derangements,... read more

The Neurohormonal Basis of Pulmonary Hypertension in HFpEF

Nonoperative Management of Splenic Injury of Patients with Reduced Consciousness is Safe and Feasible in Well-equipped Institutions

This study shows that NOM for blunt splenic trauma is a viable treatment modality in well-equipped institutions, regardless of the patients mental status. However, the presence of neurologic impairment is associated with... read more

Nonoperative Management of Splenic Injury of Patients with Reduced Consciousness is Safe and Feasible in Well-equipped Institutions

Ultrasound-based Clinical Profiles for Predicting the Risk of Intradialytic Hypotension in Critically Ill Patients on Intermittent Dialysis

In critically ill patients on intermittent hemodialysis, the absence of hypervolemia as assessed by lung and vena cava ultrasound predisposes to intradialytic hypotension and suggests alternative techniques of hemodialysis... read more

Ultrasound-based Clinical Profiles for Predicting the Risk of Intradialytic Hypotension in Critically Ill Patients on Intermittent Dialysis

Adaptive Mechanical Ventilation with Automated Minimization of Mechanical Power

Adaptive mechanical ventilation with automated minimization of inspiratory power may lead to more lung-protective ventilator settings when compared with adaptive mechanical ventilation according to Otis' equation. Comparing... read more

Adaptive Mechanical Ventilation with Automated Minimization of Mechanical Power

Pulmonary Artery Catheters for Adult Patients in ICU

Pulmonary Artery Catheters (PAC) is a diagnostic and haemodynamic monitoring tool but not a therapeutic intervention. Our review concluded that use of a PAC did not alter the mortality, general ICU or hospital LOS, or cost... read more

Pulmonary Artery Catheters for Adult Patients in ICU

Practical Trends in Anesthesia and Intensive Care 2018

This book offers an essential guide to managing the most-debated hot topics of practical interest in anesthesia and intensive care. It reviews the state of the art in issues concerning both intensive care medicine and anesthesia,... read more

Practical Trends in Anesthesia and Intensive Care 2018

Using Additional Pressure Control Lines When Connecting a Continuous RRT Device to an ECMO Circuit

The present study suggests that the use of additional tubing can be considered a simple and safe method for pressure control and improvement of filter survival when connecting a continuous renal replacement therapy (CRRT)... read more

Using Additional Pressure Control Lines When Connecting a Continuous RRT Device to an ECMO Circuit

Snapshots of Hemodynamics

This new edition reviews recent developments in genetics and molecular biology and new noninvasive measurement techniques that have enabled vast improvements in the measurement and understanding of cardiovascular hemodynamics.... read more

Snapshots of Hemodynamics

Echocardiographic Assessment of Pulmonary Artery Occlusion Pressure in Ventilated Patients

TEE accurately predicts invasive PAOP ≤ 18 mmHg in ventilated patients. This further increases its diagnostic value in patients with suspected acute lung injury/acute respiratory distress syndrome. During two consecutive... read more

Echocardiographic Assessment of Pulmonary Artery Occlusion Pressure in Ventilated Patients

Mobilization Practices for Patients with Burn Injury in Critical Care

Mobilization therapy of patients with burns in the ICU was characterized by a low mobility level during mechanical ventilation with a low functional status at hospital discharge. Of the 74 patients admitted, 66% were placed... read more

Mobilization Practices for Patients with Burn Injury in Critical Care

Vasoactive Medication and Randomized Clinical Trials

Vasoactive medication is one of the cornerstones in the treatment of critically ill patients in shock. Shock can be defined as a failure of the circulatory system to provide adequate tissue perfusion resulting in cellular... read more

Vasoactive Medication and Randomized Clinical Trials

Refractory Septic Shock: Our Pragmatic Approach

Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mortality. Such... read more

Refractory Septic Shock: Our Pragmatic Approach