Nitric Oxide Inhibitors Changes and Mortality in Critically Ill Patients

Increasing asymmetric dimethylarginine (ADMA) concentrations on days 1-3 are inversely associated with mortality, however not with the same strength as high ADMA or SDMA concentrations at admission. We suggest that admission... read more

Comorbid Burden at ICU Admission in COVID-19 vs. Sepsis and ARDS

The burden of age and comorbidity is more prominent in ICU-admission for sepsis and acute respiratory distress syndrome (ARDS) than for COVID-19. This is likely to be caused by a combination of COVID-19 affecting the relatively... read more

Low-Frequency Ventilation May Facilitate Weaning in ARDS Treated with ECMO

Low-frequency ventilation is comparable to conventional protective ventilation in patients with ARDS who have been treated with ECMO. However, low-frequency ventilation may support weaning from invasive mechanical ventilation... read more

Predictors of High-flow Nasal Cannula Failure in COVID-19 Patients

A retrospective cohort study was conducted during the months of March and May 2021. Data collection was based on a follow-up of 156 hospitalized patients with a diagnosis of COVID-19 who were users of high-flow nasal cannula... read more

Hematological, Inflammatory and Serological Responses Among COVID-19 ICU Patients

A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission. Significant... read more

Antithrombin III Levels and Outcomes Among Patients With Trauma

In this cohort study of trauma patients, antithrombin III deficiency was associated with greater severity of illness and worse hospital outcomes. Specifically, antithrombin III deficiency was associated with fewer ventilator-free... read more

Hyperoxemia in Acute Trauma is Common and Associated with a Longer Hospital Stay

This study indicate that hyperoxemia is not associated with increased 28-day mortality compared to normoxemia. Nonetheless, both moderate and severe hyperoxemia are frequently detected in trauma patients, with severe hyperoxemia... read more

Sepsis Mortality Prediction in ICU Patients Using Machine Learning

This study has achieved significant advancements in predicting sepsis outcomes by utilizing advanced machine learning techniques and sophisticated data preprocessing methods. These methods include data grouping and effective... read more

Fluid boluses and infusions in the early phase of resuscitation from septic shock and sepsis-induced hypotension

Fluid administration is the first line treatment in intensive care unit (ICU) patients with sepsis and septic shock. While fluid boluses administration can be titrated by predicting preload dependency, the amount of other... read more

Longitudinal Vasoactive Inotrope Score Trajectories and Their Prognostic Significance in Critically Ill Sepsis Patients

This study offers significant insights into the prognostic value of VIS trajectories in sepsis patients. The identification of distinct trajectory patterns not only underscores the heterogeneity in sepsis but also emphasizes... read more

Factors Affecting the Duration of Hospitalization in Urology and Nephrology Patients in the ICU

Factors affecting ICU stay length in Urology and Nephrology patients who required close monitoring and specialized medical staff were investigated. The study found a positive association between prolonged ICU stays and elevated... read more

Ventilator-associated Pneumonia Risk Factors in Patients with Severe COVID-19

Patients with COVID-19 are at high risk of VAP, which may be related to issues other than prolonged mechanical ventilation (MV) time. Multiple factors increase the chances of these patients developing VAP, including:... read more

Prevalence and Risk Factors of ICU-acquired Weakness in COVID-19 Patients

The prevalence of ICUAW in patients with COVID-19 was considered relatively high. Older age, pre-existing hypertension, medical intervention of prone position, NMBA use, needed tracheostomy and RRT were likely risk factors.... read more

Pressure Support Ventilation During ECMO Support in Patients with ARDS

In the initial phases of veno-venous extracorporeal membrane oxygenation (VV ECMO) support for severe acute respiratory distress syndrome (ARDS), ultraprotective controlled mechanical ventilation (CMV) is typically employed... read more

Outcomes for Mechanically Ventilated Patients with Acute Myocardial Infarction Admitted to Medical vs Cardiac ICUs

In this multicenter, national analysis of ICU admission for critically ill patients with AMI, we found that admission to the Cardiac Intensive Care Unit (CICU) was associated with lower in-hospital mortality than patients... read more

Emergency and Prophylactic ECMO for Patients Undergoing Valve-in-Valve Transcatheter Aortic Valve Implantation with Small Surgical Bioprosthesis

Mechanical circulatory support (MCS) using veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is widely implemented as a rescue device in transcatheter aortic valve implantation (TAVI). Although prophylactic... read more

Device Associated Complications in the ICU

Although mortality in the intensive care unit (ICU) has declined over time, ICU associated complications remain common, affecting up to a half of critically ill patients and resulting in increased mortality, longer hospital... read more

How to end quiet suffering in the ICU? Identifying and treating hypoactive delirium

The duration of time a person spends in hypoactive delirium predicts higher rates of death, longer length of stay, higher costs of care, and higher rates of acquired dementia in the months and years following critical illness.... read more

Risk Factors for Mortality in Patients with Sepsis or Sepsis-associated Delirium Based on the MIMIC-IV Database

Research on the severity and prognosis of sepsis with or without progressive delirium is relatively insufficient. We constructed a prediction model of the risk factors for 28-day mortality in patients who developed sepsis... read more

Withholding Early Parenteral Nutrition on 2-year Mortality in Critically Ill Adults

Late-PN did not alter 2-year survival and physical functioning in adult critically ill patients, independent of anticipated nutritional risk. In this prospective follow-up study of the multicenter EPaNIC randomized controlled... read more

BPRI and Clinical Outcomes in Patients with Septic Shock

Use of the novel dose-effect index, Blood Pressure Response Index (BPRI) was proposed to allow rapid bedside assessment of the reactivity of septic shock patients to vasoactive drugs, as isolated MAP or VIS cannot reflect... read more

AI to Predicting Mortality Risk in ICU Patients with AKI

To address the limitations of early acute kidney injury (AKI) prediction, researchers have increasingly turned to machine learning methods. However, the success of these models hinges on the selection of relevant features.... read more