The Precogs Take On Sepsis

The Precogs Take On Sepsis

It seems like every week there’s another publicized instance of our impending replacement by artificial intelligence. Big Data, they say, is going to free us of the cognitive burdens of complex thought while maximizing... read more

The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical ICU patients

The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical ICU patients

Aged, critically ill surgical patients have greater organ dysfunction and incidence of adverse clinical outcomes after sepsis. Biomarker profiles suggest an immunophenotype of persistent immunosuppression and catabolism.... read more

Feasibility and observed safety of interactive video games for physical rehabilitation in the ICU

Feasibility and observed safety of interactive video games for physical rehabilitation in the ICU

Novel use of interactive video games as part of routine PT in critically ill patients is feasible and appears safe in our case series. Video game therapy may complement existing rehabilitation techniques for ICU patients.... read more

Nurse intuition may play a role in critical-care outcomes

Nurse intuition may play a role in critical-care outcomes

Nurse intuition doesn't sound scientific, but it could play a key role in critical-care outcomes, according to a small study published in DovePress. The researchers conducted a descriptive phenomenological study, interviewing... read more

Alfred ICU Intubation Checklist

Alfred ICU Intubation Checklist

Here is the Alfred ICU intubation checklist. We invite you to take it and adopt it whole, or, even better, to modify it to your own department's needs. We have spent considerable time and thought developing it, as well as... read more

PPIs do not increase risk for C. difficile infection in ICU

PPIs do not increase risk for C. difficile infection in ICU

Proton pump inhibitors are not associated with an increased risk for Clostridium difficile infection in ICU patients, according to the results of a retrospective cohort study. PPI use was not associated with a significant... read more

Comparison of Two Lidocaine Administration Techniques on Perceived Pain From Bedside Procedures

Comparison of Two Lidocaine Administration Techniques on Perceived Pain From Bedside Procedures

Bedside procedures are exceedingly common. Data regarding the severity of procedural pain and strategies to mitigate it are important for the informed consent process and patient satisfaction. Overall, pain reported from... read more

Does Lactate Clearance Prognosticates Outcomes in ECMO Therapy

Does Lactate Clearance Prognosticates Outcomes in ECMO Therapy

Changes in lactate levels after ECMO implantation is an important tool to assess effective circulatory support and it is found superior to single lactate measurements as a prognostic sign of mortality in our study. Based... read more

Never Underestimate the Simple Things We Do To Our Patients

Never Underestimate the Simple Things We Do To Our Patients

In this compelling episode, Professor Paul Wischmeyer, shares some of his experiences as a patient in the ICU. Since he was 15 he has endured multiple hospitalizations and ICU stays for his inflammatory bowel disease. This... read more

Imaging platform captures hard-to-track bacterial lung infections in real time

Imaging platform captures hard-to-track bacterial lung infections in real time

Ahsan Akram and colleagues have created a fluorescent imaging probe that can quickly and accurately detect hard-to-trace Gram-negative bacteria (one of the major bacterial groups) in human lungs within minutes. Their first-in-human... read more

Proton-Pump Inhibitor Prophylaxis in the ICU

Proton-Pump Inhibitor Prophylaxis in the ICU

Critical illness can disrupt local and systemic mechanisms that protect against upper gastrointestinal bleeding, a condition that may be associated with increased mortality, particularly among patients receiving extracorporeal... read more

Chasing Mortality Endpoints is a Fool’s Errand

Chasing Mortality Endpoints is a Fool’s Errand

"There is no mortality benefit for that." How many times have you heard that? The implication is usually the same: that intervention is a waste of time. A smart, evidence-based clinician wouldn't bother with it. But, what... read more

Dopamine Antagonists in ICU Delirium

Dopamine Antagonists in ICU Delirium

Perhaps the most vexing problem in a patient in an intensive care unit (ICU) is an unexpected change in mental status. Historically, "acute encephalopathy" was the term used to encompass such alterations, but "delirium" is... read more

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness

The use of haloperidol or ziprasidone, as compared with placebo, in patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the ICU did not significantly alter the duration of delirium.... read more