Drug does not significantly reduce duration of mechanical ventilation for COPD patients

Drug does not significantly reduce duration of mechanical ventilation for COPD patients

Among mechanically ventilated patients with COPD, administration of the respiratory stimulant acetazolamide did not significantly reduce the duration of invasive mechanical ventilation.... read more

The Ability of ICU Physicians to Estimate Long-Term Prognosis in Survivors of Critical Illness

The Ability of ICU Physicians to Estimate Long-Term Prognosis in Survivors of Critical Illness

Prognoses estimated by physicians incorrectly predicted long-term survival and HRQoL in one-third of ICU survivors. Moreover, inaccurate prognoses were generally the result of overoptimistic expectations of outcome. Among... read more

Association Between mRNA Expression of CD74 and IL10 and Risk of ICU-acquired Infections

Association Between mRNA Expression of CD74 and IL10 and Risk of ICU-acquired Infections

Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs and mortality. To date, no biomarker has shown sufficient evidence and ease of application in clinical routine for the identification... read more

Post-ICU Psychological Morbidity in Very Long ICU Stay Patients with ARDS and Delirium

Post-ICU Psychological Morbidity in Very Long ICU Stay Patients with ARDS and Delirium

Delirium was associated with memory impairment and PTSS-14 scores suggestive of PTSD, but not illness severity. 181 subjects were included. Illness severity did not correlate with delirium duration. On logistic regression,... read more

Current Clinical Nutrition Practices in Critically Ill Patients in Latin America

Current Clinical Nutrition Practices in Critically Ill Patients in Latin America

In the ICU setting in Latin America, malnutrition was highly prevalent and caloric intake failed to meet targeted energy delivery in 40% of critically ill adults receiving nutrition therapy. Supplemental administration of... read more

Microcirculatory assessment of patients under VA-ECMO

Microcirculatory assessment of patients under VA-ECMO

Of the 24 patients included in the study population, 15 survived and 9 died while on VA-ECMO. PVD of the sublingual microcirculation at initiation of VA-ECMO can be used to predict ICU mortality in patients with cardiogenic... read more

Acetaminophen in the ICU: Mixed Findings

Acetaminophen in the ICU: Mixed Findings

Does having a fever help fight infection? Patients who got acetaminophen to relieve fever while in intensive care units did about as well as patients who got a placebo when it came to mortality. But in a puzzling finding,... read more

Most pediatric ICU physicians don’t use current guidelines to diagnose acute kidney injury

Most pediatric ICU physicians don’t use current guidelines to diagnose acute kidney injury

A study by University at Buffalo researchers has shown that physicians in pediatric intensive care units are not using the newest guidelines to diagnose acute kidney injury (AKI) in critically ill children, a practice that... read more

Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study

Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study

The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. A multicenter observational cohort study in ten intensive care units (ICU) in France.... read more

Performance of a Modern Glucose Meter in ICU

Performance of a Modern Glucose Meter in ICU

Performance of a Modern Glucose Meter in ICU and General Hospital Inpatients: 3 Years of Real-World Paired Meter and Central Laboratory Results. Due to accuracy concerns, the Food and Drug Administration issued guidance to... read more

Restricting volumes of resuscitation fluid in adults with septic shock after initial management

Restricting volumes of resuscitation fluid in adults with septic shock after initial management

A protocol restricting resuscitation fluid successfully reduced volumes of resuscitation fluid compared with a standard care protocol in adult ICU patients with septic shock.... read more

The Association of Early Combined Lactate and Glucose Levels with Subsequent Renal and Liver Dysfunction

The Association of Early Combined Lactate and Glucose Levels with Subsequent Renal and Liver Dysfunction

Abnormal combined lactate and glucose measurements may provide an early indication of organ dysfunction. In critically ill patients a 'normal' glucose with an elevated lactate should not be considered desirable, as this combination... read more

Standardize ICU Admission Practices to Cut Costs

Standardize ICU Admission Practices to Cut Costs

Hospitals that admitted patients to ICUs more often were more likely to routinely perform invasive procedures and incur higher costs with no commensurate improvement in mortality.... read more

Hospitals with most heart patients in ICU have worse results: Study

Hospitals with most heart patients in ICU have worse results: Study

Heart attack or heart failure patients are more likely to get worse or die at hospitals that are more likely to treat them in the ICU, a new study suggests.... read more

Glycemic control, mortality, and hypoglycemia in critically ill patients

Glycemic control, mortality, and hypoglycemia in critically ill patients

Network meta-analysis showed no mortality benefit of tight glycemic control in critically ill patients, but fivefold more hypoglycemia versus mild or very mild control. Thirty-six randomized trials (17,996 patients) were... read more

Preventing Harm in the ICU – Building a Culture of Safety and Engaging Patients and Families

Preventing Harm in the ICU – Building a Culture of Safety and Engaging Patients and Families

Preventing harm remains a persistent challenge in the ICU despite evidence-based practices known to reduce the prevalence of adverse events. This review seeks to describe the critical role of safety culture and patient and... read more

Clinicians’ Perception and Experience of Organ Donation From Brain-Dead Patients

Clinicians’ Perception and Experience of Organ Donation From Brain-Dead Patients

ICU clinicians are primarily involved in organ donation after brain death of ICU patients. Their perceptions of organ donation may affect outcomes. Our objective was to describe ICU clinician’s perceptions and experience... read more