Tag: infection
Alterations in qSOFA, SIRS, MEWS or NEWS Score Present in Half of Patients
Almost half of patients with a suspected infection experience a change in the score of qSOFA, SIRS, MEWS and/or NEWS during ED stay. Approximately half of alterations were from a normal to an abnormal score and half vice... read more
Procalcitonin-guided Antibiotic Treatment Effect on Mortality in Acute Respiratory Infections
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols... read more
Identification of Biomarkers, New Treatments, and Vaccines for COVID-19
The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are... read more
Burden of Post-Sepsis Morbidity Higher Than Previously Thought
A recent cohort study published in JAMA based on data from 116,507 survivors of hospital-treated sepsis in Germany sheds light on the heavy burden of long-term effects of sepsis, the most severe complication of infections. The... read more
COVID-19 Infection Triggers Profibrotic Macrophage Responses and Lung Fibrosis
COVID-19-induced acute respiratory distress syndrome (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyzed... read more
MR-proADM Role in the Stratification Risk of COVID-19 Patients Assessed at the Triage of the Emergency Department
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the Emergency Departments have been overrun with suspicious COVID-19 patients, creating a pressing need to optimize resources through risk... read more
COVID-19 and Myocardial Infarction
COVID-19 is a risk factor for myocardial infarction and stroke through self-controlled case series evaluation, a method that has been used to establish the risk of myocardial infarction associated with influenza infection. Regarding... read more
The Relationship Between Vitamin D and Asthma Exacerbation
Asthma is a chronic airway inflammatory condition that affects millions of people worldwide. It presents with reversible bronchoconstriction that makes it difficult for patients to breathe. Asthma flare-ups have several triggers,... read more
Higher CRP Rise Not Related To Cytokine Response
The higher C-reactive protein (CRP) rise with late parenteral nutrition (PN), explained by the early macronutrient deficits, did not relate to cytokine responses and thus did not reflect more systemic inflammation. Instead... read more
Coronavirus Disease 2019 (COVID-19): Epidemiology, Pathogenesis, Diagnosis, and Therapeutics
This book provides a comprehensive overview of recent novel coronavirus (SARS-CoV-2) infection, their biology and associated challenges for their treatment and prevention of novel Coronavirus Disease 2019 (COVID-19). Discussing... read more
No Extra Risk For Transferring ECMO COVID-19 Patients
Previous experience has shown that transporting patients on extracorporeal membrane oxygenation (ECMO) is a safe and effective mode of transferring critically ill patients requiring maximum mechanical ventilator support to... read more
Post COVID-19 and Patients with and without Pre-existing ILD
A lot remains to be learned about the long-term effects of patients with interstitial lung disease (ILD) who survive COVID-19 infections. Clinicians need to better understand and recognize the effects of post-COVID 19 lung... read more
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role... read more
Acute Eosinophilic Pneumonia Secondary to Daptomycin
Daptomycin is an antimicrobial agent with activity against gram-positive bacteria that is usually reserved for severe infections. Acute eosinophilic pneumonia (AEP) is an increasingly rare side effect that can manifest after... read more
Not all COVID waves look the same. Here’s a snapshot of the Delta surge
Waves of Covid can give you an awful sense of déjà vu. As "Hot Vax Summer" gave way early to Delta-anxious fall, you could be forgiven for feeling a familiar sense of dread, not so different from what you’d felt before... read more
Can Early Cytokine Profile Discriminate Between GPB and GNB?
Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive... read more
Difference in Sepsis Patients Outcomes Between First and Second-Hit Infections
Our study identifies a fundamental difference in patient outcomes between first-hit and second-hit bacterial infections, which may be due to genetic, microbiological, immunological, and environmental factors. This finding... read more
Multicomponent Sepsis Transition Effect and Recovery Program After Sepsis
In a multisite randomized clinical trial of patients hospitalized with sepsis, patients provided with a 30-day program using a nurse navigator to provide best practices for postsepsis care experienced a lower proportion of... read more
Differential Dynamics of Peripheral Immune Responses to Acute COVID-19 Infection in Older Adults
In this study, peripheral blood mononuclear cells from young and old patients with COVID-19 were examined phenotypically, transcriptionally and functionally to reveal age-, time- and severity-specific adaptations. Gene... read more
ABCDEF Bundle Implementation for ICU Patients During the COVID-19
Regardless of COVID-19 infection status, implementation rates for the ABCDEF bundle, for each element individually and an ICU diary were extremely low for patients without and with COVID-19 infections during the pandemic.... read more
The Use of Different Sepsis Risk Stratification Tools Uncovers Different Mortality Risks
Our data suggest that the sepsis risk stratification tools currently utilized in emergency departments and on the general wards do not predict mortality adequately. This is illustrated by the disparity in mortality risk... read more
Neurological Complications After First Dose of COVID-19 Vaccines
Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate... read more
