Tag: infection
Efficacy of β-Blockers in Decreasing Mortality in Sepsis and Septic Shock Patients
This study suggests that the use of β-blockers in sepsis and septic shock patients is associated with a significant decrease in in-hospital mortality and also associated with better patient outcomes. As β-blockers cause... read more
Hospitalizations for Multisystem Inflammatory Syndrome in Children (MIS-C) in US
Multisystem inflammatory syndrome in children (MIS-C) is a rare, serious condition characterized by fever and multiorgan involvement that occurs after SARS-CoV-2 infection. US Centers for Disease Control and Prevention... read more
Trends in Empiric Broad-Spectrum Antibiotic Use for Suspected Community-Onset Sepsis in US Hospitals
Empiric treatment for suspected community-onset sepsis accounts for about half of broad-spectrum antibiotic use in US hospitals even though resistant organisms are isolated in only 7% of patients with community-onset sepsis... read more
Sepsis Alert Systems, Mortality, and Adherence in Emergency Departments
This systematic review and meta-analysis demonstrated the significant association of implementing sepsis alert systems in the Emergency Departments (ED) with patient outcomes. These findings indicate that sepsis alert... read more
Secretomic Approach Value in COVID-19 Viral Pneumonia Among Patients With Respiratory Distress
this article presents an innovative and promising secretomic analysis to distinguish VPP patients from NV-ICU patients using combinations of protein markers. Among the identified proteins, ficolin-3 and proteoglycan-4 appear... read more
The Existence of Adrenal Insufficiency in COVID-19 Patients with Pneumonia
Patients with a history of COVID-19 pneumonia who present with clinical symptoms such as shock, nausea, vomiting, and fatigue should have hypocortisolism included in the differential diagnosis. These patients should also... read more
COVID-19 Infections Are Growing
Large areas of the US are experiencing a significant spread of COVID-19, with the pandemic reaching alarming levels. Data from the Centers for Disease Control and Prevention indicates that the spread of the disease has officially... read more
Dexamethasone Systemic Effects in Severe COVID-19
Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk... read more
Emergency Department Disposition and Mortality in COVID‐19 Patients with ARDS
Compared to direct ICU admission, admission from the ED to the ward is associated with increased mortality in patients who meet COVID‐19 ARDS criteria during their hospitalization, despite lower 4C and similar SAPS‐III... read more
Endothelial Dysfunction and Persistent Inflammation in Severe Post-COVID-19 Patients
Six months after ICU discharge from severe ARDS secondary to COVID-19, patients with gas exchange impairment exhibit evidence of systemic inflammation, along with elevated ICAM-1 levels, ultimately resulting in increased... read more
BARDA Selected Host-directed Therapeutic Candidates to Address ARDS
Biomedical Advanced Research and Development Authority (BARDA) has selected host-directed therapeutic candidates for inclusion in a phase 2 platform clinical trial to address acute respiratory distress syndrome (ARDS). Currently,... read more
Predictive Value of Multiple Scoring Systems in the Prognosis of Septic Patients with Different Infection Sites
The heterogeneity nature of sepsis is significantly impacted by the site of infection. This study aims to explore the predictive value of multiple scoring systems in assessing the prognosis of septic patients across different... read more
Secretomic Approach Value for Distinguishing Patients with COVID-19 Viral Pneumonia Among ICU Patients with Respiratory Distress
In intensive care units, COVID-19 viral pneumonia patients (VPP) present symptoms similar to those of other patients with Nonviral infection (NV-ICU). To better manage VPP, it is therefore interesting to better understand... read more
Sepsis: Methods and Protocols
This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical... read more
Immunosuppression Not Associated with a Higher Incidence of ICU-acquired Bacterial Bloodstream Infections
In this monocentric, retrospective observational cohort study, the incidence of ICU-acquired bacterial BSI was not different between immunocompromised and non-immunocompromised patients. This suggests that the clinical... read more
Sepsis Management in Resource-limited Settings
This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More... read more
Workbook on Renal Replacement Therapy in ICU (ISCCM)
This workbook focuses on renal replacement therapy in ICU. The incidence of acute kidney injury in critically ill patients is increasing steeply. Acute kidney injury in this setting is associated with high morbidity and mortality.... read more
