Tag: infection

Research Aims to Fine-Tune Sepsis Diagnosis

Work designed to improve diagnosis of one of the leading causes of death in children is under way in Brisbane, led by a University of Queensland researcher. Mater Research Institute-UQ Associate Professor Luregn Schlapbach... read more

Incidence of NV-HAP in the United States

Because nonventilator hospital-acquired pneumonia (NV-HAP) is understudied, our purpose was to determine the incidence, overall burden, and level of documented pneumonia preventive interventions of NV-HAP in 24 U.S. hospitals.... read more

Sepsis Patients can be Risk Stratified at the Time of Diagnosis

Multicenter Meta-Analysis Reveals Sepsis Patients can be Risk Stratified at the Time of Diagnosis Demonstrating Potential to Improve Critical Care Medicine on a Global Scale. For this study, the team identified a large collection... read more

How The Burn Trauma ICU Eliminated Central Line Infections

Is zero possible? In the case of central line infections, the answer was once no. A CLABSI (central line associated blood stream infection) was once considered a car crash, or an expected inevitability of care. When University... read more

Danger Signals in the ICU

Damage-associated molecular pattern activation and release is an important research for intensive care practitioners. It will add to our understanding of the phase and state of the innate immune response to an insult. Early... read more

On Diagnosing Sepsis

Two years ago, a panel appointed by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine, referred to as a consensus conference, proposed a new definition for sepsis and new diagnostic... read more

Sepsis Incidence: A Population-Based Study

The incidence of sepsis with organ dysfunction is higher than most previous estimates independent of definition. The inclusion of all inpatients started on intravenous antibiotic treatment of sepsis in a population makes... read more

Oral Versus Intravenous Antibiotics for the Treatment Of Bone and Joint Infection

Oral antibiotic therapy is non-inferior to IV therapy when used during the first six weeks in the treatment for bone and joint infection, as assessed by definitive treatment failure within one year of randomisation. These... read more

Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock

Two in three hypotensive sepsis patients were responsive to initial fluid resuscitation. Heart failure, hypothermia, immunocompromise, hyperlactemia, and coagulopathy were associated with the refractory phenotype. Fluid resuscitation... read more

The Overlooked Danger of Delirium in Hospitals

The condition, once known as "ICU psychosis," disproportionately affects seniors and those who have been heavily sedated—and the delusions can last long after they're discharged. Patients treated in intensive-care units... read more

Do We Need New Trials of Procalcitonin-Guided Antibiotic Therapy?

Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect... read more

AI Can Predict Sepsis to Save Lives

Emory University researchers have created a "Sepsis Expert" algorithm that works in real time to predict the onset of sepsis, the deadly condition that often takes hold in healthcare settings. Banking on information from... read more

Risk Factors for Ventilator-Associated Events in a PICU

There is an association between ventilator-associated condition and infection-related ventilator-associated complication in critically ill children with acute kidney injury, ventilatory support, and neuromuscular blockade.... read more

Managing Sepsis and Septic Shock Current Guidelines and Definitions

While sepsis defies simple definition, it's generally understood to be a clinical syndrome caused by infection that may have profound adverse physiologic consequences. Although its precise incidence is unknown, sepsis is... read more

Differences in Impact of Definitional Elements on Mortality Precludes International Comparisons of Sepsis Epidemiology

Within a sepsis cohort, we illustrate case-mix heterogeneity using definitional elements (infection source and organ dysfunction). In the context of improving outcomes, we illustrate differential secular trends in impact... read more

Defining Sepsis on the Wards: Comparing Two Sepsis Definitions

Sepsis is defined as a dysregulated host response to infection, resulting in acute organ dysfunction. Although the condition has been thoroughly studied in the intensive care unit (ICU), accurate data collection outside of... read more

What Is PICS and How Does it Affect Patients and Families

Every year, about 6 million people are admitted to intensive care units with a life-threatening illness. As medical technology advances, more people survive conditions that once would have been fatal. However, about half... read more

Importance of Second Antibiotic Doses in ED Sepsis Patients

Most studies evaluating early antibiotic administration in sepsis patients focus on timing of the first dose. We highlight many of these studies in our recent review article on Appropriate Antibiotic Therapy in Emergency... read more

Is Fever the Normal Temperature of Sepsis

We know that hypothermia in sepsis is associated with increased mortality but other than that we tend to see fever in sepsis as something bad. We tend to perceive sepsis patients as more sick the more the temperature is elevated.... read more

Should We Manage All Septic Patients Based on a Single Definition?

It is indisputable from the biological and clinical perspectives that not all cases of sepsis are the same. On the contrary, most have great many differences, that is, different portals of entry, clinical manifestations,... read more

ECMO for Severe Middle East Respiratory Syndrome Coronavirus

Extracorporeal membrane oxygenation (ECMO) use, as a rescue therapy, was associated with lower mortality in MERS patients with refractory hypoxemia. The results of this, largest to date, support the use of ECMO as a rescue... read more

Diagnostic Stewardship for Healthcare-Associated Infections

Healthcare-associated infections (HAIs) are associated with increased morbidity and mortality, prolonged hospital stays, and unnecessary cost. The financial stakes of HAIs for hospitals were underscored in 2008 when the Centers... read more