Estimating Seroprevalence of COVID-19 Infection After Omicron Outbreak

Estimating Seroprevalence of COVID-19 Infection After Omicron Outbreak

This study aimed to investigate the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies among individuals aged 18 years and older. Population-based study was conducted within the Arizona... read more

Sepsis Prediction Model for Determining Sepsis vs. SIRS, qSOFA, and SOFA

Sepsis Prediction Model for Determining Sepsis vs. SIRS, qSOFA, and SOFA

In this cohort study of 60,507 hospital admissions, we found that although the SPM marginally outperformed existing prediction scores in balanced accuracy for classification of sepsis, it suffers from poor timeliness, limiting... read more

Ferroptosis and Pyroptosis Signatures in Critical COVID-19 Patients

Ferroptosis and Pyroptosis Signatures in Critical COVID-19 Patients

Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and pyroptosis are two detrimental forms... read more

Blood Purification for Adult Patients with Sepsis

Blood Purification for Adult Patients with Sepsis

Our network meta-analysis (NMA) suggests that plasma exchange and polymyxin-B hemoperfusion may provide potential benefits for adult patients with severe infection or sepsis/septic shock when compared with standard care alone,... read more

Staphylococcus Epidermidis Infections Linked to ICU Septic Shocks

Staphylococcus Epidermidis Infections Linked to ICU Septic Shocks

Bloodstream infections caused by Staphylococcus epidermidis (SE-BSI) may lead to septic shock in patients admitted to intensive care unit (ICU), according to a study. For the study, researchers looked at a retrospective... read more

Cluster of Carbapenemase-Producing Carbapenem-Resistant Pseudomonas Aeruginosa Among ICU Patients

Cluster of Carbapenemase-Producing Carbapenem-Resistant Pseudomonas Aeruginosa Among ICU Patients

Treatment of carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) infections is challenging because of antibiotic resistance. CP-CRPA infections are highly transmissible in health care settings because... read more

Reducing Mortality in Critically Ill Patients

Reducing Mortality in Critically Ill Patients

This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least... read more

Effect of Antimicrobial De-escalation Strategy on 14-day Mortality Among ICU Patients

Effect of Antimicrobial De-escalation Strategy on 14-day Mortality Among ICU Patients

The prevalence of antimicrobial de-escalation (ADE) strategy was low among intensive care unit patients. The ADE strategy demonstrated a protective effect or no adverse effect on 14-day mortality compared to the No Change... read more

Balloon-Blowing Exercise Effect on Oxygen Saturation in COVID-19 Patients

Balloon-Blowing Exercise Effect on Oxygen Saturation in COVID-19 Patients

Balloon therapy is an empirical example that patients with respiratory tract diseases can use to improve their daily care. The diaphragm and ribs are expanded and raised by the intercostal muscles, which are activated during... read more

Risk Factor for Superimposed Nosocomial BSI in Hospitalized COVID-19 Patients

Risk Factor for Superimposed Nosocomial BSI in Hospitalized COVID-19 Patients

Unmodified risk variables for nosocomial bloodstream infections (BSIs) included male sex and leukocytosis at admission. Using methylprednisolone and obtaining a cumulative dosage of dexamethasone were adjusted risk variables... read more

The Song of the Cell: An Exploration of Medicine and the New Human

The Song of the Cell: An Exploration of Medicine and the New Human

In the late 1600s, Mukherjee sets the stage for an extraordinary tale. It revolves around two notable individuals: Robert Hooke, a renowned English polymath, and Antonie van Leeuwenhoek, an eccentric Dutch cloth-merchant.... read more

Choosing Wisely Interventions to Reduce Antibiotic Overuse

Choosing Wisely Interventions to Reduce Antibiotic Overuse

These real-world multicomponent interventions responding to physician pay-for-performance (P4P) incentives were associated with substantial reductions in antibiotic prescriptions for acute respiratory tract infections (ARTIs)... read more

Increased Fungal Infections Hospitalizations during COVID-19

Increased Fungal Infections Hospitalizations during COVID-19

An examination of a large healthcare database in the United States revealed a significant rise in hospitalization rates related to fungal infections between 2019 and 2021. This increase was primarily driven by hospitalizations... read more

Rapid Sepsis Tests Using Magnetic Nanoparticles

Rapid Sepsis Tests Using Magnetic Nanoparticles

Qun Ren, an Empa researcher, and her team are currently developing a diagnostic procedure that can rapidly detect life-threatening blood poisoning caused by staphylococcus bacteria. Staphylococcal sepsis is fatal in up... read more

Biggest AMR dilemma: to give, or not to give antibiotics?

Biggest AMR dilemma: to give, or not to give antibiotics?

Sepsis (a dysregulated reaction of the body to infection with 50 million cases per year) must be treated with antibiotics as soon as it is suspected — ideally, within the first hour. Antibiotics are thus easily administered... read more

Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments in the United States about two confirmed outbreaks of Marburg... read more

Antifungal Stewardship in Critically Ill Patients

Antifungal Stewardship in Critically Ill Patients

Antifungal stewardship (AFS) can improve performance measures and decrease antifungal consumption, with no negative impact on outcomes. β-D-glucan (BDG) are helpful to stop unnecessary treatment in patients with IC,... read more