Tag: inflammation
Thrombocytosis in the ED
Both reactive thrombocytosis and clonal thrombocytosis may be associated with vasomotor symptoms. The key difference is that thrombotic and bleeding events are much more common in myeloproliferative thrombocytosis, whereas... read more
Crizanlizumab use lowers rates of sickle cell crises
Patients with sickle cell disease treated with high-dose crizanlizumab experienced lower annualized rates of sickle cell crisis compared to placebo treatment, regardless of their baseline use of hydroxyurea. Those treated... read more
Exacerbation of COPD: Causes, Warning Signs, and Treatment
What is a COPD exacerbation and what are the main causes? Learn about what the symptoms are and what is suggested to try to prevent COPD. Most commonly referred to as COPD, the term describes emphysema and chronic bronchitis.... read more
SOFA score may be best to identify sepsis in the ICU
Among critically ill patients admitted to the ICU with a suspected infection, defining sepsis by an increase of two or more points in the Sequential Organ Failure Assessment (SOFA) score yielded greater prognostic accuracy... read more
Towards precision medicine for sepsis patients
Over the last decade it has become clear that the immunological response and clinical course in sepsis patients is too complex to simply regard it as hyperinflammation-induced organ failure. In contrast to the previous belief... read more
GCA independently raises risk for VTE
The risk of venous thromboembolism (VTE) increases markedly shortly before the diagnosis of giant cell arteritis (GCA) regardless of glucocorticoid exposure, peaks at the time of diagnosis, and then progressively declines,... read more
COPD and Life Expectancy
COPD is the third leading cause of death after heart disease and cancer. Chronic obstructive pulmonary disease is a term for many health conditions that affect a person's lungs on a chronic basis. The condition causes... read more
Normal Saline as Resuscitation Fluid in Critically Ill
The study of Van Regenmortel et al. indirectly underscores growing equipoise in the expert medical community regarding the presumed harmful effects of NS compared with balanced crystalloids. Future studies, such as the ongoing... read more
Clinical challenge in IBD expanded by Systemic inflammation
More targeted antibody therapies carry the potential to transform how physicians treat inflammatory bowel disease. However, management can become less clear when IBD patients present with extra-intestinal manifestations.... read more
Therapy Implications for Immunomodulation After Ischemic Stroke
Despite significant advances towards a better understanding of the pathophysiology of ischemic stroke-induced immunosuppression and SAP in recent years, many unanswered questions remain. The true incidence and outcomes of... read more
New anti-inflammatory drug reduces death of existing brain cells then repairs damage after stroke
Researchers at The University of Manchester have discovered that a potential new drug reduces the number of brain cells destroyed by stroke and then helps to repair the damage.... read more
Could a Metabolic Switch Explain Inflammation in Lupus Patients?
Researchers discovered a new mechanism linking specific classes of immune cells and metabolism, a finding that may explain why patients with lupus are incapable of controlling the inflammatory responses that ultimately lead... read more
Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery
Single measurements of the synthesis rate and/or transcapillary escape rate of albumin obviously cannot explain the plasma level of albumin or the changes seen in plasma albumin concentration.... read more
Increased global, subcutaneous inflammation in psoriasis
Psoriasis patients have increased global arterial inflammation and subcutaneous inflammation, according to a study published online Oct. 27 in the British Journal of Dermatology.... read more
Patients benefit from tranexamic acid in surgery, withholding blood pressure meds before
Four innovative studies exploring ways to reduce complications related to heart surgery or minimize patient mortality due to risks associated with low blood pressure and surgery.... read more
Immune system of African Americans responds more strongly to bacterial infection, and it is partly genetic
A Canada-US study has demonstrated that Americans of African descent have a stronger immune response to infection compared to Americans of European descent.... read more
Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis
The outcome of treating two patients with FMT indicates that restoration of the intestinal microbiota barrier can alleviate the infection and modulate the immune response.... read more
