The Sick Bowel Obstruction Patient

A 68-year-old female presents to the ED with abdominal pain, bloating, and nausea which she states began this morning upon wakening about 3 hours prior to arrival. She appears moderately uncomfortable and pale. She is urgently... read more

The Sick Bowel Obstruction Patient

Electronic Dura Mater Meddling in the Central Nervous System

This review of preclinical applications assesses the potential of the electronic dura mater to deliver electrical and chemical stimulation to targeted areas of the central nervous system for extended periods. Soft neural... read more

Electronic Dura Mater Meddling in the Central Nervous System

Thrombocytosis in the ED

Both reactive thrombocytosis and clonal thrombocytosis may be associated with vasomotor symptoms. The key difference is that thrombotic and bleeding events are much more common in myeloproliferative thrombocytosis, whereas... read more

Thrombocytosis in the ED

Crizanlizumab use lowers rates of sickle cell crises

Patients with sickle cell disease treated with high-dose crizanlizumab experienced lower annualized rates of sickle cell crisis compared to placebo treatment, regardless of their baseline use of hydroxyurea. Those treated... read more

Crizanlizumab use lowers rates of sickle cell crises

Exacerbation of COPD: Causes, Warning Signs, and Treatment

What is a COPD exacerbation and what are the main causes? Learn about what the symptoms are and what is suggested to try to prevent COPD. Most commonly referred to as COPD, the term describes emphysema and chronic bronchitis.... read more

Exacerbation of COPD: Causes, Warning Signs, and Treatment

SOFA score may be best to identify sepsis in the ICU

Among critically ill patients admitted to the ICU with a suspected infection, defining sepsis by an increase of two or more points in the Sequential Organ Failure Assessment (SOFA) score yielded greater prognostic accuracy... read more

SOFA score may be best to identify sepsis in the ICU

Towards precision medicine for sepsis patients

Over the last decade it has become clear that the immunological response and clinical course in sepsis patients is too complex to simply regard it as hyperinflammation-induced organ failure. In contrast to the previous belief... read more

Towards precision medicine for sepsis patients

GCA independently raises risk for VTE

The risk of venous thromboembolism (VTE) increases markedly shortly before the diagnosis of giant cell arteritis (GCA) regardless of glucocorticoid exposure, peaks at the time of diagnosis, and then progressively declines,... read more

GCA independently raises risk for VTE

COPD and Life Expectancy

COPD is the third leading cause of death after heart disease and cancer. Chronic obstructive pulmonary disease is a term for many health conditions that affect a person's lungs on a chronic basis. The condition causes... read more

COPD and Life Expectancy

Normal Saline as Resuscitation Fluid in Critically Ill

The study of Van Regenmortel et al. indirectly underscores growing equipoise in the expert medical community regarding the presumed harmful effects of NS compared with balanced crystalloids. Future studies, such as the ongoing... read more

Normal Saline as Resuscitation Fluid in Critically Ill

Clinical challenge in IBD expanded by Systemic inflammation

More targeted antibody therapies carry the potential to transform how physicians treat inflammatory bowel disease. However, management can become less clear when IBD patients present with extra-intestinal manifestations.... read more

Clinical challenge in IBD expanded by Systemic inflammation

Therapy Implications for Immunomodulation After Ischemic Stroke

Despite significant advances towards a better understanding of the pathophysiology of ischemic stroke-induced immunosuppression and SAP in recent years, many unanswered questions remain. The true incidence and outcomes of... read more

Therapy Implications for Immunomodulation After Ischemic Stroke

New anti-inflammatory drug reduces death of existing brain cells then repairs damage after stroke

Researchers at The University of Manchester have discovered that a potential new drug reduces the number of brain cells destroyed by stroke and then helps to repair the damage.... read more

New anti-inflammatory drug reduces death of existing brain cells then repairs damage after stroke

Could a Metabolic Switch Explain Inflammation in Lupus Patients?

Researchers discovered a new mechanism linking specific classes of immune cells and metabolism, a finding that may explain why patients with lupus are incapable of controlling the inflammatory responses that ultimately lead... read more

Could a Metabolic Switch Explain Inflammation in Lupus Patients?

Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery

Single measurements of the synthesis rate and/or transcapillary escape rate of albumin obviously cannot explain the plasma level of albumin or the changes seen in plasma albumin concentration.... read more

Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery

Increased global, subcutaneous inflammation in psoriasis

Psoriasis patients have increased global arterial inflammation and subcutaneous inflammation, according to a study published online Oct. 27 in the British Journal of Dermatology.... read more

Increased global, subcutaneous inflammation in psoriasis

Patients benefit from tranexamic acid in surgery, withholding blood pressure meds before

Four innovative studies exploring ways to reduce complications related to heart surgery or minimize patient mortality due to risks associated with low blood pressure and surgery.... read more

Patients benefit from tranexamic acid in surgery, withholding blood pressure meds before