Epidemiology of Invasive Pulmonary Aspergillosis Among COVID-19 Intubated Patients

Epidemiology of Invasive Pulmonary Aspergillosis Among COVID-19 Intubated Patients

We found a high incidence of CAPA among critically ill COVID-19 patients and that its occurrence seems to change the natural history of disease. A total of 108 patients were enrolled. Prospective, multicentre study... read more

All Intensivists Are Not Created Equal

All Intensivists Are Not Created Equal

I’d like to preface this story by saying that the majority of the intensivists I have worked with have been exceptional, caring, and professional. We had all established a good camaraderie, and we had mutual respect for... read more

Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy

Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy

To the best of our knowledge, this is the first multicenter study that prospectively evaluated the benefits and the role of HFNO combined with awake prone positioning in the prevention of intubation in an adjusted large cohort... read more

Early Arterial Embolization and Mortality in Mechanically Ventilated Patients With Hemoptysis

Early Arterial Embolization and Mortality in Mechanically Ventilated Patients With Hemoptysis

The objective of this study was to clarify whether early intervention by arterial embolization reduced mortality in mechanically ventilated patients with hemoptysis. The results show that early intervention by arterial... read more

Use and Outcomes of Nasotracheal Intubation Among Patients Requiring Mechanical Ventilation Across U.S. PICUs

Use and Outcomes of Nasotracheal Intubation Among Patients Requiring Mechanical Ventilation Across U.S. PICUs

Nasotracheal intubation is used in a minority of U.S. PICUs and mainly among young cardiac patients. Nasotracheal intubation is associated with a lower rate of unplanned extubations in this patient population. Future... read more

Obesity and the Risk of Intubation or Death in Patients with COVID-19

Obesity and the Risk of Intubation or Death in Patients with COVID-19

Among consecutive patients hospitalized with coronavirus disease 2019, obesity was an independent risk factor for intubation or death. A total of 305 patients were included in this study. We stratified patients by body... read more

Awake Prone Positioning for COVID-19 Hypoxemic Respiratory Failure

Awake Prone Positioning for COVID-19 Hypoxemic Respiratory Failure

Infection with SARS-CoV-2 can result in Coronavirus Disease–19 (COVID-19). While the majority of patients are asymptomatic or have mild disease, approximately 14% develop more severe disease including hypoxemic respiratory... read more

Prone Positioning in Non-intubated Patients with COVID-19

Prone Positioning in Non-intubated Patients with COVID-19

As the COVID-19 pandemic has put severe stress and strain on the capacity of hospitals around the world, concerted efforts have been made to evaluate therapeutics aimed at preventing the need for mechanical ventilation. The... read more

Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol in ICU

Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol in ICU

Approaches to removal of sedation and mechanical ventilation for critically ill patients vary widely. Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)—ie, daily interruption of sedatives—with... read more

Computer Tomographic Assessment of Gastric Volume in Major Trauma Patients

Computer Tomographic Assessment of Gastric Volume in Major Trauma Patients

In major trauma patients, overall stomach volume deriving from food, fluids and air must be expected to be around 400–500 mL. Gastric dilation caused by air is common but not typically associated with pre-hospital airway... read more

Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

Respiratory Strategies for Patients with Suspected or Proven COVID-19 Respiratory Failure

The trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19. The... read more

High Breath-by-Breath Variability Is Associated With Extubation Failure in Children

High Breath-by-Breath Variability Is Associated With Extubation Failure in Children

High respiratory variability during spontaneous breathing trials is independently associated with extubation failure in children, with very high rates of extubation failure when these children develop postextubation upper... read more

Bedside PUG Tube Placement by Critical Care Physicians

Bedside PUG Tube Placement by Critical Care Physicians

Critically ill patients often require gastrostomy tubes. Percutaneous endoscopic gastrostomy has become the most common method of placement but is not widely performed by critical care physicians, in part due to their lack... read more

COVID-19: Airborne Particle Contamination Increased Substantially Using the Aerosol Box

COVID-19: Airborne Particle Contamination Increased Substantially Using the Aerosol Box

Study shows that aerosol box used to protect healthcare workers during COVID intubation increases, rather than decreases, exposure to airborne particles. A new study shows that aerosol boxes that have been manufactured... read more

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Cardiovascular Phenotypes in Ventilated Patients with COVID-19 ARDS

Approximately two-thirds of patients admitted to the intensive care unit (ICU) for coronavirus disease-19 (COVID-19) pneumonia present with the acute respiratory distress syndrome (ARDS). COVID-19-associated acute cardiac... read more

Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events

Difficult Bag-Mask Ventilation in Critically Ill Children Is Independently Associated With Adverse Events

Difficult bag-mask ventilation is reported in approximately one in 10 PICU patients undergoing tracheal intubation. Given its association with adverse procedure–related events and oxygen desaturation, future study is warranted... read more

Perhaps something isn’t always better than nothing

Perhaps something isn’t always better than nothing

It is not unreasonable to say the COVID-19 pandemic caught most of us by surprise. We did not know how infectious the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) virus leading to COVID-19 disease was, nor... read more