Systematic Approach to the Peripheral Vascular Exam: Pearls & Pitfalls

Systematic Approach to the Peripheral Vascular Exam: Pearls & Pitfalls

A 62-year-old male with a history of hypertension, congestive heart failure, type II diabetes mellitus, and tobacco use presents to the emergency department (ED) with severe left lower leg pain that started six hours ago.... read more

Lipid Mediators in Critically Ill Patients: A Step Towards Precision Medicine

Lipid Mediators in Critically Ill Patients: A Step Towards Precision Medicine

In this review, we provide an overview of the role of fatty acid-derived lipid mediators as endogenous regulators of the inflammatory, anti-inflammatory and pro-resolving response and future directions for use of clinical... read more

Impact of implantation time on early function of cardiac transplant

Impact of implantation time on early function of cardiac transplant

Data on out-of-ice implantation ischemia in heart transplant are scarce. We examined implantation time's impact on allograft dysfunction.METHODS: We conducted a single-site retrospective review of all primary adult heart... read more

Association Between Hypothermia/Ischemia Ratio and Functional Outcome From Out-of-Hospital Cardiac Arrest

Association Between Hypothermia/Ischemia Ratio and Functional Outcome From Out-of-Hospital Cardiac Arrest

Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more

Association Between Hypothermia/Ischemia Ratio and Functional Outcome

Association Between Hypothermia/Ischemia Ratio and Functional Outcome

Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more

Quantitative EEG for Detection of Brain Ischemia

Quantitative EEG for Detection of Brain Ischemia

Electroencephalography (EEG) is a very promising tool for monitoring brain function in real-time in the ICU. There are characteristic changes that occur on EEG in response to brain ischemia, correlating with CBF and brain... read more

Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications

Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications

A comprehensive review of the scientific and clinical studies that have led to the resurgence of interest in hypothermia as a neuroprotective strategy in the treatment of stroke and traumatic brain injury (TBI). Topics... read more

Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest

Tailoring Hypothermia Duration to Ischemia Duration Improve Outcome From Out-of-Hospital Cardiac Arrest

Although a larger hypothermia/ischemia ratio was associated with good functional outcome after out-of-hospital cardiac arrest in this cohort, this association is primarily driven by duration of time to return of spontaneous... read more

Mechanical Ventilation in Patients with Acute Ischemic Stroke

Mechanical Ventilation in Patients with Acute Ischemic Stroke

Although there are no specific data regarding the effect of respiratory management on stroke patients' outcomes, specific ventilator strategies in this population could potentially improve neurologic outcome and prevent respiratory... read more

Recombinant Thrombomodulin on Neutrophil Extracellular Traps in Murine Intestinal Ischemia-Reperfusion

Recombinant Thrombomodulin on Neutrophil Extracellular Traps in Murine Intestinal Ischemia-Reperfusion

Recombinant thrombomodulin improved the survival of male mice with intestinal ischemia–reperfusion injury. These findings suggest that histone and neutrophil extracellular trap accumulation exacerbate remote liver injury... read more

Early Detection and Monitoring of Cerebral Ischemia Using Calcium-Responsive MRI Probes

Early Detection and Monitoring of Cerebral Ischemia Using Calcium-Responsive MRI Probes

The duration of cerebral ischemia is a key factor in determining the severity of brain damage and the course of action. Thus, an accurate and timely observation of the ischemic process is highly critical. Here we present... read more

Myocardial Ischemia During Ventilator Weaning

Myocardial Ischemia During Ventilator Weaning

This observational study showed the pulmonary edema (WiPO) occurred in a significant number of critically ill patients who failed a first spontaneous breathing trial (SBT), while cardiac ischemia (WiCI) was less frequent.... read more

Possible Link Between Splanchnic Circulatory Changes and Exhaled CH4

Possible Link Between Splanchnic Circulatory Changes and Exhaled CH4

The aim of this study was to explore the possible link between splanchnic circulatory changes and exhaled CH4 in an attempt to recognize intestinal perfusion failure. Methane (CH4) breath test is an established diagnostic... read more

Stress Ulcer Prophylaxis with Proton Pump Inhibitors or Histamin-2 Receptor Antagonists in Adult Intensive Care Patients

Stress Ulcer Prophylaxis with Proton Pump Inhibitors or Histamin-2 Receptor Antagonists in Adult Intensive Care Patients

In this updated systematic review, we were able to refute a relative change of 20% of mortality. The occurrence of GI bleeding was reduced, but we lack firm evidence for a reduction in clinically important GI bleeding. The... read more