Prone Positioning of Nonintubated Patients with COVID-19

Prone Positioning of Nonintubated Patients with COVID-19

Despite the significant variability in frequency and duration of prone positioning and respiratory supports applied, prone positioning was associated with improvement in oxygenation variables without any reported serious... read more

Agreement Between IVC Diameter Measurements by Subxiphoid vs. Transhepatic Views

Agreement Between IVC Diameter Measurements by Subxiphoid vs. Transhepatic Views

When it is not possible to obtain the subcostal view, it is possible to use the lateral transhepatic view. However, using the percentage variation in IVC size is likely to be more reliable than the absolute diameter alone.... read more

Discharged IMV COVID-19 Survivors Not Functionally Independent

Discharged IMV COVID-19 Survivors Not Functionally Independent

The majority of invasive mechanical ventilation (IMV) COVID-19 survivors were not functionally independent at discharge and required significant follow-up medical care. The COVID-19 circumstance has placed constraints on... read more

Expiratory Flow Limitation During Mechanical Ventilation

Expiratory Flow Limitation During Mechanical Ventilation

Expiratory flow limitation (EFL) is present when the flow cannot rise despite an increase in the expiratory driving pressure. The mechanisms of EFL are debated but are believed to be related to the collapsibility of small... read more

Assess the Intensity of Inspiratory Efforts Using CVP Waveforms

Assess the Intensity of Inspiratory Efforts Using CVP Waveforms

Real case: You are passing by the room of an awake mechanically ventilated patient with advanced IPF. Peeking in from outside the room, the following CVP waveform catches your attention. In a recent post, we discussed... read more

Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults

Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults

In this study, low baseline diaphragm muscle mass in critically ill patients was associated with prolonged mechanical ventilation, complications of acute respiratory failure, and an increased risk of death in the hospital. A... read more

90 Day Outcomes of COVID-19 Patients in European ICUs

90 Day Outcomes of COVID-19 Patients in European ICUs

This communication delineates outcomes in COVID-19 patients in the context of ARDS severity, ventilatory management, and variables associated with mortality on a 90-day follow-up for subgroups of patients after ICU admission.... read more

Individualized vs. Fixed Positive End-expiratory Pressure for Intraoperative Mechanical Ventilation in Obese Patients

Individualized vs. Fixed Positive End-expiratory Pressure for Intraoperative Mechanical Ventilation in Obese Patients

This secondary analysis of obese patients undergoing laparoscopic surgery found better oxygenation, lower driving pressures, and redistribution of ventilation toward dependent lung areas measured by electrical impedance tomography... read more

A Controlled Trial of Methylprednisolone in COVID-19 Pneumonia

A Controlled Trial of Methylprednisolone in COVID-19 Pneumonia

The use of corticosteroids in patients with pneumonia secondary to COVID-19 has been a controversially hot topic, particularly early on in the pandemic. Prior evidence seen in Severe Acute Respiratory Syndrome (SARS) and... read more

Clinical Features and Predictors in Critically Ill COVID-19 Patients

Clinical Features and Predictors in Critically Ill COVID-19 Patients

We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was a multicentered prospective study with clinical and laboratory details. Details for fifty uncomplicated COVID-19... read more

Prone Position in Intubated, Mechanically Ventilated COVID-19 Patients

Prone Position in Intubated, Mechanically Ventilated COVID-19 Patients

During the COVID-19 pandemic, prone position has been widely adopted to treat mechanically ventilated patients with respiratory failure. The majority of patients improved their oxygenation during prone position, most likely... read more

IVCDV is not a reliable indicator of preload responsiveness

IVCDV is not a reliable indicator of preload responsiveness

During mechanical ventilation with Vt = 6 mL/kg, the effects of passive leg raising (PLR) can be assessed by changes in pulse pressure variation (PPV). If inferior vena cava diameter (IVCDV) is used, it should be expressed... read more

Effect of intubation timing on clinical outcomes of critically ill patients with COVID-19

Effect of intubation timing on clinical outcomes of critically ill patients with COVID-19

The synthesized evidence suggests that timing of intubation may have no effect on mortality and morbidity of critically ill patients with COVID-19. These results might justify a wait-and-see approach, which may lead to fewer... read more

Replacement of Fentanyl Infusion by Enteral Methadone Decreases the Weaning Time From Mechanical Ventilation

Replacement of Fentanyl Infusion by Enteral Methadone Decreases the Weaning Time From Mechanical Ventilation

The introduction of enteral methadone during weaning from sedation and analgesia in mechanically ventilated patients resulted in a decrease in the weaning time from mechanical ventilation (MV). A double-blind randomized... read more

24-Hour Esophageal pH Measurement in Mechanically Ventilated Children

24-Hour Esophageal pH Measurement in Mechanically Ventilated Children

The current study shows high incidence of gastroesophageal reflux on 24-hour esophageal pH-metry in mechanically ventilated children with medical diagnoses. The significance of this finding and its impact on ventilator-associated... read more

Early Tracheotomy Shortens ICU Stay and Lowers Risk of VAP

Early Tracheotomy Shortens ICU Stay and Lowers Risk of VAP

Compared with late tracheotomy, early intervention was associated with lower ventilator-associated pneumonia (VAP) rates and shorter durations of mechanical ventilation and ICU stay, but not with reduced short-term, all-cause... read more

Ventilator Weaning and Discontinuation Practices for Critically Ill Patients

Ventilator Weaning and Discontinuation Practices for Critically Ill Patients

In this observational study of invasive mechanical ventilation discontinuation in 142 ICUs in Canada, India, the UK, Europe, Australia/New Zealand, and the US from 2013 to 2016, weaning practices varied internationally. Among... read more