Tag: mechanical ventilation
International Variation in Intubation and Extubation Practices Among Critically Ill Patients Receiving Mechanical Ventilation
Requiring invasive mechanical ventilation acutely outside an operating room is, for many, the definition of critical illness. Although there may be debate regarding whether patients treated with noninvasive ventilation or... read more
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial
In critically ill mechanically ventilated patients, early sedation with dexmedetomidine exhibited a high probability of reduced 90-day mortality in older patients regardless of operative or non-operative cluster status. Conversely,... read more
Body Mass Index and Risk for COVID-19
Obesity* is a recognized risk factor for severe COVID-19, possibly related to chronic inflammation that disrupts immune and thrombogenic responses to pathogens as well as to impaired lung function from excess weight. Obesity... read more
Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation
Among patients with unhealthy alcohol use receiving mechanical ventilation, treatment with high-dose baclofen, compared with placebo, resulted in a statistically significant reduction in agitation-related events. The primary... read more
High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure
The use of high-flow nasal oxygen upon ICU admission in adult patients with COVID-19 related acute hypoxemic respiratory failure may lead to an increase in ventilator-free days and a reduction in ICU length of stay, when... read more
Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19
Treatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence... read more
Temporal Changes in the Epidemiology, Management, and Outcome from ARDS
The frequency of and outcome from ARDS remained relatively stable between 2002 and 2012. Plateau pressure > 29 cmH2O and driving pressure > 14 cmH2O on the first day of mechanical ventilation but not tidal volume > 8... read more
The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients
Previous case series reported an association between dexmedetomidine use and hyperthermia. Temperature data have not been systematically reported in previous randomized controlled trials evaluating dexmedetomidine. Our... read more
Effect of Nurse-Led GDLPT on the Prognosis of Pneumonia in Sepsis Patients in the ICU
Nurse-led goal-directed lung physical therapy (GDLPT) improved the outcomes of pneumonia in sepsis patients, and was particularly associated with shortened mechanical ventilation duration and ICU stay, and reduced ICU mortality... read more
Physiological dead space and alveolar ventilation in ventilated infants
Prematurely born infants with pulmonary disease have a higher dead space than term controls, which may influence the optimum level during volume-targeted ventilation. A prospective study of mechanically ventilated infants... read more
Causes and Timing of Death in Critically Ill COVID-19 Patients
Mortality rate of critically ill COVID-19 patients is high, especially in those requiring invasive mechanical ventilation. However, the causes and the timing of death of patients admitted to the ICU for SARS-CoV-2 pneumonia... read more
SOFA Score Accuracy For Determining Mortality Of Severely Ill Patients With COVID-19 Pneumonia
The SOFA score possesses inadequate discriminant accuracy to be used for ventilator triage of COVID-19 patients. A better option is needed that incorporates variables specifically related to mortality in patients with COVID-19... read more
Innovations in ICU Ventilation
Many centuries ago, Socrates stated that "the secret of change is to focus all of your energy, not on fighting the old, but on building the new." Nowadays, we may relate his quote with the concept of innovation, which is... read more
Epidemiology and microbiology of ventilator-associated pneumonia in COVID-19 patients
The COVID-19 pandemic is responsible for many hospitalizations in intensive care units (ICU), with widespread use of invasive mechanical ventilation (IMV) which exposes patients to the risk of ventilator-associated pneumonia... read more
Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?
COVID-19 is an infectious respiratory disease caused by a coronavirus called SARS-CoV-2. If the infection becomes severe, people may need intensive care and support in hospital, including mechanical ventilation. Drugs... read more
Barotrauma in Mechanically-ventilated Patients with COVID-2019
Within the limits of a survey, patients with COVID-19 might be at high risk for barotrauma during invasive (and allegedly lung-protective) mechanical ventilation. The response rate was 38/61 (62%). The incidence of... read more
COVID-19 and VILI: Mechanical Power Measurement
The COVID-19 pandemic has increased the need for a bedside tool for lung mechanics assessment and ventilator-induced lung injury (VILI) monitoring. Mechanical power is a unifying concept including all the components which... read more
