Imaging Changes of Severe COVID-19 Pneumonia in Advanced Stage

Imaging Changes of Severe COVID-19 Pneumonia in Advanced Stage

The imaging changes of acute stage from a case of 75-year-old male patient with severe COVID-19 pneumonia combined acute respiratory distress syndrome (ARDS), septic shock, and multiple organ dysfunction syndrome (MODS) who... read more

Harmful Effects of Mechanical Ventilation on Neurocognitive Functions

Harmful Effects of Mechanical Ventilation on Neurocognitive Functions

Whether mechanical ventilation (MV) induces neurotoxicity that can trigger or accelerate chronic cognitive disorders is controversial. The relationship between MV and neurocognitive impairment, that persisted at hospital... read more

New Study on Prehospital Airway Control Trial Underway

New Study on Prehospital Airway Control Trial Underway

Emory University Department of Emergency Medicine and Grady Memorial Hospital will take part in a U.S. Department of Defense-funded clinical trial to compare different ways to help people with traumatic injuries breathe. The... read more

Respiratory Drive in the ARDS: Pathophysiology, Monitoring, and Therapeutic Interventions

Respiratory Drive in the ARDS: Pathophysiology, Monitoring, and Therapeutic Interventions

Neural respiratory drive, i.e., the activity of respiratory centres controlling breathing, is an overlooked physiologic variable which affects the pathophysiology and the clinical outcome of acute respiratory distress syndrome... read more

It’s Insane to Keep Using Mortality As a Primary Endpoint in Critical Care Trials

It’s Insane to Keep Using Mortality As a Primary Endpoint in Critical Care Trials

Mortality is an important endpoint, so we shouldn't ignore mortality trends entirely. However, the vast majority of these will be spurious. Thus, we should generally not change practice due to them. In the history of critical... read more

Coronavirus (2019-nCoV): Evidence Relevant to Critical Care

Coronavirus (2019-nCoV): Evidence Relevant to Critical Care

The 2019 Coronavirus outbreak was declared a global Public Health Emergency by the World Health Organization (WHO) on 30th January 2020. In order to ensure immediate access to relevant systematic reviews, this Cochrane... read more

Ventilatory Support and Mechanical Properties of the Fibrotic Lung Acting as a “Squishy Ball”

Ventilatory Support and Mechanical Properties of the Fibrotic Lung Acting as a “Squishy Ball”

The management of the patient with lung fibrosis in the ICU is a challenge for the intensivist. The lack of studies defining the mechanical ventilation strategy, and the different underlying etiologies, make it difficult... read more

Expiratory Muscle Dysfunction in Critically Ill Patients

Expiratory Muscle Dysfunction in Critically Ill Patients

The expiratory muscles are the "neglected component" of the respiratory muscle pump. Rather as the heart does not comprise only a left ventricle, but also a right one, the respiratory muscle pump is much more than just the... read more

The ABCDE Bundle Associated with Significant Reductions in Duration of Mechanical Ventilation

The ABCDE Bundle Associated with Significant Reductions in Duration of Mechanical Ventilation

The focus on long-term consequences of critical illness has intensified with increasing ICU utilization and survivorship. Post Intensive Care Syndrome (PICS) is increasingly recognized and has profound and long-lasting negative... read more

Clinical Decision Support Systems: Future or Present in ICU?

Clinical Decision Support Systems: Future or Present in ICU?

Clinical decision support systems (CDSS) are today, a reality. More complex, useful systems will be developed in the near future, forging CDSS an essential part of ICU monitoring. However, we need to understand the algorithms... read more

Risk Factors for the Development of ARDS in Mechanically Ventilated Adults in Peru

Risk Factors for the Development of ARDS in Mechanically Ventilated Adults in Peru

In this study of mechanically ventilated patients, 31% of study participants had acute respiratory distress syndrome (ARDS) at some point during their ICU stay. Optimal lung-protective ventilation was not used in a majority... read more

Effect of Stress Ulcer Prophylaxis on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

Effect of Stress Ulcer Prophylaxis on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

Among ICU patients requiring mechanical ventilation, a strategy of stress ulcer prophylaxis with use of proton pump inhibitors vs histamine-2 receptor blockers resulted in hospital mortality rates of 18.3% vs 17.5%, respectively,... read more

Compliance With Evidence-Based Processes of Care After Transitions Between Staff Intensivists

Compliance With Evidence-Based Processes of Care After Transitions Between Staff Intensivists

No significant impact of transitions of care observed between individual staff physicians on evidence-based processes of care for mechanically ventilated adult patients. However, transitions were associated with a lower likelihood... read more

Ventilator Management: Advanced Concepts In Critical Care

Ventilator Management: Advanced Concepts In Critical Care

Mechanical ventilation is a broad subject that encompasses many factors that must be considered while providing overall resuscitation. It is not as easy as just entering in a rate and tidal volume and pushing start. Critical... read more