Pilot Study to Assess the Feasibility and Safety of Intermittent Enteral Feeding in Mechanically Ventilated Medical ICU Patients

Pilot Study to Assess the Feasibility and Safety of Intermittent Enteral Feeding in Mechanically Ventilated Medical ICU Patients

With the advent of the feeding pump, default enteral nutrition schedules in many medical intensive care units has shifted from intermittent or bolus feeding to continuous feeds. Clinical studies suggest that each of these... read more

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

In adults undergoing mechanical ventilation in the ICU, the use of conservative oxygen therapy, as compared with usual oxygen therapy, did not significantly affect the number of ventilator-free days. The number of ventilator-free... read more

Cardiac Intensive Care

Cardiac Intensive Care

Using a multidisciplinary, team-oriented approach, this unique title expertly covers all the latest approaches to the assessment, diagnosis, and treatment of patients with critical cardiac illness. Led by Dr David L. Brown,... read more

High-Flow Nasal Cannula vs. Noninvasive Ventilation

High-Flow Nasal Cannula vs. Noninvasive Ventilation

High-flow conditioned oxygen therapy delivered through nasal cannulae and noninvasive mechanical ventilation (NIV) may reduce the need for reintubation. Therefore, Hernández et al set out to test if high-flow conditioned... read more

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure

Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation. Among 364 randomized... read more

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Ventilation

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Ventilation

This complex randomized, controlled trial failed to demonstrate that early extubation to non-invasive ventilation reduced the total time of mechanical ventilation. I will continue to extubate early and will use non-invasive... read more

Long-term Cognitive Impairment and Delirium in ICU

Long-term Cognitive Impairment and Delirium in ICU

ICU delirium was positively associated with impaired information processing speed and executive functioning at six-months post-discharge for this cohort. Testing for cognitive impairment with RBANS and TMT should be considered... read more

Impact of a Multifaceted Prevention Program on VAP Including Selective Oropharyngeal Decontamination

Impact of a Multifaceted Prevention Program on VAP Including Selective Oropharyngeal Decontamination

Ventilator-associated pneumonia (VAP) remains a serious complication of mechanical ventilation (MV), and has an incidence between 2 and 16 episodes per 1000 ventilator-days, an attributable mortality of 5–13%, excess ICU... read more

Management of Peripheral Venoarterial ECMO in Cardiogenic Shock

Management of Peripheral Venoarterial ECMO in Cardiogenic Shock

Extracorporeal membrane oxygenation (ECMO) is a powerful mechanical circulatory support modality capable of rapidly restoring systemic perfusion yet lacking in defined approaches to management. Adopting a management approach... read more

Sedation, Sleep Promotion, and Delirium Screening Practices in the Care of Mechanically Ventilated Children

Sedation, Sleep Promotion, and Delirium Screening Practices in the Care of Mechanically Ventilated Children

The results highlight the heterogeneity in sedation practices among intensivists who care for critically ill children as well as a paucity of sleep promotion and delirium screening in PICUs worldwide. The survey was completed... read more

Interventions for Preventing Critical Illness Polyneuropathy and Critical Illness Myopathy

Interventions for Preventing Critical Illness Polyneuropathy and Critical Illness Myopathy

There is moderate quality evidence from two large trials that intensive insulin therapy reduces CIP/CIM, and high quality evidence that it reduces duration of mechanical ventilation, ICU stay and 180-day mortality, at the... read more

Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients

Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients

Liberating patients from ongoing invasive mechanical ventilation is typically a 3-step process. First, clinicians must recognize that patients may no longer require mechanical ventilation, when the reasons for intubation... read more

Early Enteral Nutrition Associated with Improved Clinical Outcomes in Critically Ill Children

Early Enteral Nutrition Associated with Improved Clinical Outcomes in Critically Ill Children

In critically ill children with hyperglycemia requiring inotropic support and/or mechanical ventilation, early enteral nutrition was independently associated with better clinical outcomes. Of 608 eligible subjects, 331... read more

Brainstem Responses Can Predict Death and Delirium in ICU Sedated Patients

Brainstem Responses Can Predict Death and Delirium in ICU Sedated Patients

Assessment of brainstem responses is feasible in sedated critically ill patients and loss of selected responses is predictive of mortality and altered mental status. 72 patients were included in the initial group and 72... read more