Effect Sizes in Ongoing Randomized Controlled Critical Care Trials

Effect Sizes in Ongoing Randomized Controlled Critical Care Trials

For some of the largest ongoing critical care trials, many clinicians regard prior probabilities as low and consider that plausible effects on absolute mortality are less than 5%. Further work is needed to determine whether... read more

Long-Term Outcomes and Health Care Utilization after Prolonged Mechanical Ventilation

Long-Term Outcomes and Health Care Utilization after Prolonged Mechanical Ventilation

Critically ill patients who undergo mechanical ventilation in an ICU for longer than 21 days have high in-hospital mortality and greater postdischarge mortality, health care utilization, and health care costs compared with... read more

Impact of Delayed Admission to ICUs on Mortality of Critically Ill Patients

Impact of Delayed Admission to ICUs on Mortality of Critically Ill Patients

When the number of patients who require intensive care is greater than the number of beds available, intensive care unit (ICU) entry flow is obstructed. This phenomenon has been associated with higher mortality rates... read more

Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality

Accuracy of Quick Sequential Organ Failure Assessment Score to Predict Sepsis Mortality

Overall, quick Sequential Organ Failure Assessment score outperforms systemic inflammatory response syndrome in predicting sepsis outcome, but quick Sequential Organ Failure Assessment score has relative strengths/weaknesses... read more

Noninvasive Ventilation in Pneumonia-induced Early Stage Mild ARDS

Noninvasive Ventilation in Pneumonia-induced Early Stage Mild ARDS

Treatment with noninvasive ventilation (NIV) did not reduce the need for intubation among patients with pneumonia-induced early mild acute respiratory distress syndrome (ARDS), despite the improved PaO2/FIO2 observed with... read more

Comparison of Echocardiographic Indices of RVEF in Critically Ill Patients

Comparison of Echocardiographic Indices of RVEF in Critically Ill Patients

Though echocardiographic evaluation assesses the right ventricular systolic function, which of the existing parameters best reflects the right ventricular ejection fraction (RVEF) in the critically ill patients is still uncertain.... read more

Impact of Critical Illness on Resource Utilization

Impact of Critical Illness on Resource Utilization

An ICU admission is associated with increased resource utilization including hospital readmissions, with many due to an ambulatory care sensitive condition. Lower socioeconomic status and higher severity of illness are associated... read more

Refractory Septic Shock: Our Pragmatic Approach

Refractory Septic Shock: Our Pragmatic Approach

Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mortality. Such... read more

Association Between Mean Arterial Pressure and AKI and a Composite of Myocardial Injury and Mortality in Postoperative Critically Ill Patients

Association Between Mean Arterial Pressure and AKI and a Composite of Myocardial Injury and Mortality in Postoperative Critically Ill Patients

Hypotension thresholds that provoke renal injury, myocardial injury, and mortality in critical care patients remain unknown. We primarily sought to determine the relationship between hypotension and a composite of myocardial... read more

Physical Function Impairment in Survivors of Critical Illness in an ICU Recovery Clinic

Physical Function Impairment in Survivors of Critical Illness in an ICU Recovery Clinic

Physical function measurement in a recovery clinic is feasible and may inform subsequent morbidity and mortality. 36 patients were seen in clinic from July 2014 to June 2015; the median SPPB score was 5 (IQR 5). The... read more

Intensive vs. Conventional Glucose Control in Critically Ill Patients

Intensive vs. Conventional Glucose Control in Critically Ill Patients

n this large, international, randomized trial, we found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did... read more

Effect of a Sepsis Educational Intervention on Hospital Stay

Effect of a Sepsis Educational Intervention on Hospital Stay

Adherence to a bundle strategy is low following an educational intervention. However, when patients are managed after instruction in guideline recommendations, hospital stay may be significantly reduced. The main cause... read more

Use of Machine Learning to Analyze Routinely Collected ICU Data

Use of Machine Learning to Analyze Routinely Collected ICU Data

The rate of publication of studies using machine learning to analyze routinely collected ICU data is increasing rapidly. The sample sizes used in many published studies are too small to exploit the potential of these methods.... read more

Clinical Examination for the Prediction of Mortality in the Critically Ill

Clinical Examination for the Prediction of Mortality in the Critically Ill

Clinical examination has reasonable discriminative value for assessing 90-day mortality in acutely admitted ICU patients. In our study population, a single, protocolized clinical examination had similar prognostic abilities... read more