Among US adults, higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident cardiovascular disease (CVD) and all-cause mortality in a dose-response manner. 29,615 adults pooled from 6 prospective cohort studies in the United States with a median follow-up of 17.5 years, each additional 300 mg of dietary cholesterol consumed per day was significantly associated with higher risk of incident CVD and all-cause mortality, and each additional half an egg consumed per day was significantly associated with higher risk of incident CVD and all-cause mortality. This analysis included 29,615 participants of whom 13,299 (44.9%) were men and 9,204 (31.1%) were black. During a median follow-up of 17.5 years (interquartile range, 13.0-21.7; maximum, 31.3), there were 5,400 incident CVD events and 6,132 all-cause deaths. These results should be considered in the development of dietary guidelines and updates.

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