A Rare Group of White Blood Cells May Be the Secret to Prevent Sepsis

A Rare Group of White Blood Cells May Be the Secret to Prevent Sepsis

Basophils are evolutionarily conserved in vertebrates, despite their small numbers and short life span, suggesting that they have beneficial roles in maintaining health. However, these roles are not fully defined. Here we... read more

Sepsis Incidence and Mortality are Underestimated in Australian ICU Administrative Data

Sepsis Incidence and Mortality are Underestimated in Australian ICU Administrative Data

When compared with the reference standard — prospective clinical diagnosis — ANZICS CORE database criteria significantly underestimate the incidence of sepsis and overestimate the incidence of septic shock, and also result... read more

Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock

Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock

Thiamine administration within 24 hours of admission in patients presenting with septic shock was associated with improved lactate clearance and a reduction in 28-day mortality compared with matched controls. Patients who... read more

Early Lactate Measurements Appear to Improve Results for Septic Patients

Early Lactate Measurements Appear to Improve Results for Septic Patients

The study by Churpek and colleagues was designed to evaluate both the frequency of urgent lactate measurements and their association with clinician interventions and mortality. An elevated lactate level means that a patient's... read more

Assessment of the Safety of Discharging Select Patients Directly Home From the ICU

Assessment of the Safety of Discharging Select Patients Directly Home From the ICU

The discharge of select adult patients directly home from the ICU is common, and it is not associated with increased health care utilization or increased mortality. Among the 6732 patients included in the study, 2826 (42%)... read more

Predicting Mortality in Patients Undergoing VA-ECMO After CABG

Predicting Mortality in Patients Undergoing VA-ECMO After CABG

Prediction scoring systems for coronary artery bypass grafting (CABG) patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) have not yet been reported. This study was designed to develop a predictive score... read more

Artificial Intelligence in the ICU

Artificial Intelligence in the ICU

ICU doctors are often required to analyse large volumes of complex, heterogeneous data to make life-critical decisions. Artificial Intelligence (AI), if used effectively, could reduce this burden by transforming data into... read more

Shock: Roadside to Resus

Shock: Roadside to Resus

If you're involved in the care of critically unwell patients then you will frequently encounter patients who are shocked. The European Society of Intensive Care Medicine defines shock as; "Life-threatening, generalized... read more

Haloperidol for the Management of Delirium in Adult ICU Patients

Haloperidol for the Management of Delirium in Adult ICU Patients

Among critically ill patients, haloperidol administration compared with placebo does not significantly affect short-term mortality, incidence of delirium, ICU length of stay, or delirium or coma-free days. Additionally, there... read more

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

Insulin-Treated Diabetes Reduces Dysglycemia-Related Mortality in Sepsis

Patients with sepsis and a pre-existing diagnosis of insulin-treated diabetes (ITD) may show a different relationship between hospital mortality and highest glucose levels and glycemic variability in the first 24 hours than... read more

How to Improve Worldwide Early Enteral Nutrition Performance in ICUs?

How to Improve Worldwide Early Enteral Nutrition Performance in ICUs?

Early enteral nutrition (EEN), typically started within 48 h after ICU admission, is recommended to be superior over delayed enteral nutrition and parenteral nutrition. The ESICM Working Group on Gastrointestinal Function... read more

Characterising Risk of In-Hospital Mortality Following Cardiac Arrest Using Machine Learning

Characterising Risk of In-Hospital Mortality Following Cardiac Arrest Using Machine Learning

Resuscitated cardiac arrest is associated with high mortality; however, the ability to estimate risk of adverse outcomes using existing illness severity scores is limited. Using in-hospital data available within the first... read more

Outcomes of Patients Presenting with Mild ARDS

Outcomes of Patients Presenting with Mild ARDS

Hospital mortality in acute respiratory distress syndrome (ARDS) is approximately 40%, but mortality and trajectory in "mild" acute respiratory distress syndrome (classified only since 2012) are unknown, and many cases are... read more

ICU Costs Higher for Patients Dying Before Discharge

ICU Costs Higher for Patients Dying Before Discharge

The high cost of critical care has engendered research into identifying influential factors. However, previous studies have not considered patient vital status at ICU discharge. This is what a new study has found: The largest... read more