A simple algorithm for the identification of clinical COPD phenotypes

A simple algorithm for the identification of clinical COPD phenotypes

This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses.Data from 2409 COPD patients of French/Belgian COPD cohorts... read more

Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold

Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold

Long-term mortality rates and HRQoL did not differ in patients with septic shock and anaemia who were transfused at a haemoglobin threshold of 7 g/dl versus a threshold of 9 g/dl. We may reject a more than 3 % increased hazard... read more

Surgeons Are Using Social Media to Share and Learn New Skills

Surgeons Are Using Social Media to Share and Learn New Skills

Learning from others' experiences is an important aspect of professional development in surgery. That’s why academic surgical departments across the globe hold weekly Morbidity and Mortality (M&M) conferences that gather... read more

Understanding Adrenal Crisis

Understanding Adrenal Crisis

Approximately 5–17 cases of adrenal crisis (AC) occur per 100 patient years in patients with primary or secondary adrenal insufficiency (AI). The mortality rate is estimated to be between 0.5% and 2%. Norwegian data indicate... read more

Severe AKI in Young ICU Patients Predicts Higher Mortality

Severe AKI in Young ICU Patients Predicts Higher Mortality

Acute kidney injury (AKI) among critically ill children and young adults is common and is associated with higher mortality risk and other poor outcomes The condition also is associated with greater use of renal-replacement... read more

Opioid use to worse outcomes in C. difficile

Opioid use to worse outcomes in C. difficile

A study presented at the World Congress of Gastroenterology found that patients being prescribed opioids who also have Clostridium difficile infections (CDIs) have higher peak white blood cell counts, higher creatinine elevations,... read more

Levosimendan in high-risk patients undergoing cardiac surgery

Levosimendan in high-risk patients undergoing cardiac surgery

Levosimendan reduces mortality in patients with preoperative severely reduced LVEF but does not affect overall mortality. Levosimendan reduces the need for RRT after high-risk cardiac surgery. Six RCTs were included in the... read more

2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis

2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis

Sepsis is a leading cause of death in the United States, but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on... read more

National Variation in the Use of Tracheostomy in Children Undergoing Congenital Heart Surgery

National Variation in the Use of Tracheostomy in Children Undergoing Congenital Heart Surgery

Variation in the usage of tracheostomy in infants and children undergoing congenital heart surgery exists across the country. High-tracheostomy centers had lower hospital charges. Late tracheostomy placement, higher congenital... read more

Frailty Association with Perioperative Morbidity in Patients After Ambulatory General Surgery Operations

Frailty Association with Perioperative Morbidity in Patients After Ambulatory General Surgery Operations

Frailty is associated with increased perioperative morbidity in common ambulatory general surgery operations, independent of age, type of anesthesia, and other comorbidities. Surgeons should consider frailty rather than chronological... read more

Comparison of Postoperative Outcomes Among Patients Treated by Male and Female Surgeons

Comparison of Postoperative Outcomes Among Patients Treated by Male and Female Surgeons

After accounting for patient, surgeon, and hospital characteristics, patients treated by female surgeons had a small but statistically significant decrease in 30 day mortality and similar surgical outcomes (length of stay,... read more

Hospital admissions for sepsis jump 89% in Pennsylvania

Hospital admissions for sepsis jump 89% in Pennsylvania

The number of Lehigh Valley hospital admissions for sepsis, an increasingly prevalent life-threatening complication from infections, increased by 69 percent over eight years, according to a state report released Wednesday.... read more

Effect of Systematic ICU Triage on Long-term Mortality Among Critically Ill Elderly Patients

Effect of Systematic ICU Triage on Long-term Mortality Among Critically Ill Elderly Patients

Among critically ill elderly patients in France, a program to promote systematic ICU admission increased ICU use but did not reduce 6-month mortality. Additional research is needed to understand the decision to admit elderly... read more

Traditional vs. Extended Cefepime Infusion in Critically Ill Patients

Traditional vs. Extended Cefepime Infusion in Critically Ill Patients

Patients with Pseudomonas aeruginosa bacteremia or pneumonia had a reduced 28-day all-cause mortality and length of stay in the ICU when administered an extended infusion of cefepime.... read more