Effects of Ventilatory Rescue Therapies on the Cerebral Oxygenation of COVID-19 Patients

Effects of Ventilatory Rescue Therapies on the Cerebral Oxygenation of COVID-19 Patients

A new study by Masimo published in Critical Care evaluated the impact of a variety of rescue therapies on the systemic and cerebral oxygenation of mechanically ventilated COVID-19 patients suffering from acute respiratory... read more

Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients

Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients

In this observational study of intubation practices in critically ill patients from a convenience sample of 197 sites across 29 countries, major adverse peri-intubation events—in particular cardiovascular instability—were... read more

Improving Outcomes for Children Requiring ECMO Therapy Following Hematopoietic Stem Cell Transplantation

Improving Outcomes for Children Requiring ECMO Therapy Following Hematopoietic Stem Cell Transplantation

Pediatric patients posthematopoietic stem cell transplantation supported with extracorporeal membrane oxygenation have improving survival rates over time. With 26% of patients (16/62) surviving to hospital discharge in the... read more

Effect of Intermediate-Dose vs. Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, ECMO Treatment, or Mortality Among Patients With COVID-19 in ICU

Effect of Intermediate-Dose vs. Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, ECMO Treatment, or Mortality Among Patients With COVID-19 in ICU

Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome... read more

Timing of Intubation in Patients With COVID-19

Timing of Intubation in Patients With COVID-19

The timing of intubation in hypoxemic patients with COVID-19 has been hotly debated. Early in the pandemic, there was a push to intubate early, driven by the effort to reduce transmission of the virus. With time, high-flow... read more

Monitoring tissue oxygenation index using near‐infrared spectroscopy during pre‐hospital resuscitation

Monitoring tissue oxygenation index using near‐infrared spectroscopy during pre‐hospital resuscitation

In this pilot study, we demonstrated the feasibility of ∆TOI as a dynamic value rather than single static value among OHCA patients in a pre-hospital setting. ∆TOI can be considered as a predictor of return of spontaneous... read more

Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines

Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines

Survival rates with good neurologic outcomes following conventional cardiopulmonary resuscitation (CPR) for cardiopulmonary arrest, either in the in-hospital (IH) or out-of-hospital settings, have improved but remain poor... read more

An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy

An Index Combining Respiratory Rate and Oxygenation to Predict Outcome of Nasal High-Flow Therapy

In patients with pneumonia with acute respiratory failure treated with high-flow nasal cannula (HFNC), ROX is an index that can help identify those patients with low and those with high risk for intubation. This was a... read more

COVID-19 Awake Proning – All Hype?

COVID-19 Awake Proning – All Hype?

In this prospective meta-analysis of observational studies of patients with acute hypoxemic respiratory failure due to COVID-19, APP did not result in lower intubation or mortality rates, despite reported improvements in... read more

Nebulised heparin for patients with or at risk of ARDS

Nebulised heparin for patients with or at risk of ARDS

In patients with or at risk of acute respiratory distress syndrome (ARDS), nebulised heparin did not improve self-reported performance of daily physical activities, but was well tolerated and exploratory outcomes suggest... read more

Janssen Investigational COVID-19 Vaccine

Janssen Investigational COVID-19 Vaccine

An investigational COVID-19 vaccine developed by Janssen Pharmaceuticals appears to be safe and effective at preventing moderate and severe COVID-19 in adults, according to an interim analysis of Phase 3 clinical data conducted... read more

Timing, Outcome, and Risk Factors of Intracranial Hemorrhage in ARDS Patients During VV-ECMO

Timing, Outcome, and Risk Factors of Intracranial Hemorrhage in ARDS Patients During VV-ECMO

Intracranial hemorrhage occurs early during venovenous extracorporeal membrane oxygenation (VV-ECMO) and is a determinant for 60-day mortality. Appropriate adjustment of identified modifiable risk factors might lower... read more

Apnoeic Oxygenation for Emergency Anaesthesia of Pre-hospital Trauma Patients

Apnoeic Oxygenation for Emergency Anaesthesia of Pre-hospital Trauma Patients

Apnoeic oxygenation did not influence peri-intubation oxygen saturations, but it did reduce the frequency and duration of hypoxia in the post-intubation period. Given that apnoeic oxygenation is a simple low-cost intervention... read more

ECMO in the Adult Patient (Core Critical Care)

ECMO in the Adult Patient (Core Critical Care)

Extracorporeal membrane oxygenation (ECMO) is developing rapidly, and is now part of the toolkit for the management of all patients with severe respiratory or cardiac failure. Clinicians of all disciplines are in need of... read more