Tag: research
Diagnostic Workup, Etiologies and Management of Acute Right Ventricular Failure
Right Ventricular (RV) function evaluation is key in the critically-ill patients for hemodynamic management, as fluid optimization, vasopressor strategy and respiratory support. RV failure may be diagnosed by the association... read more
ECMO in Sepsis
In this episode, Zack talks with Heidi Dalton about ECMO use in Sepsis. This is another controversial area with pediatric literature showing strong results while the adult results have been less impressive. Heidi has been... read more
Being Mortal: Medicine and What Matters in the End
Through eye-opening research and gripping stories of his own patients and family, Gawande reveals the suffering this dynamic has produced. Nursing homes, devoted above all to safety, battle with residents over the food they... read more
Time of Admission to the PICU and Mortality
Margaret Parker, MD, MCCM, speaks with Michael C. McCrory, MD, MS, about the article, "Time of Admission to the PICU and Mortality," published in the October 2017 issue of Pediatric Critical Care Medicine. Dr. McCrory discusses... read more
Human limb skeletal muscle wasting and architectural remodeling during five to ten days intubation and ventilation in critical care
Using ultrasound, we have been able to demonstrate that muscle thickness and architecture of vastus lateralis undergo rapid changes during the early phase of admission to a critical care environment. Muscle loss in critically... read more
Limiting Sedation for Patients with ARDS
Current evidence supports the use of protocol-based, light-sedation strategies in critically ill patients with ARDS. Further research into sedation management specifically in ARDS populations is needed. Deep sedation strategies... read more
Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema
Cystic fibrosis transmembrane conductance regulator potentiation by ivacaftor is a novel therapeutic approach for pulmonary edema. Ivacaftor significantly improved alveolar liquid clearance in isolated pig lung lobes ex vivo... read more
Weaning from the Ventilator and Extubation in ICU
Current research is focusing on preventing extubation failure, especially in the most challenging cases. The use of weaning protocols – written or computerized – attempts to early identify patients who are able to breathe... read more
Risk of Recurrence After Surviving Severe Sepsis
Risk of recurrence after surviving severe sepsis is substantial regardless of patient characteristics or infection sites. Further research is necessary to find underlying mechanisms for the high risk of recurrence in these... read more
What’s Your Doctor Reading? How Social Media is Disrupting Medical Education
Traditionally, research would be presented at conferences, discussed at meetings, and gradually incorporated into international guidelines and textbooks. It would then filter down into clinical practice, years after its original... read more
Johns Hopkins Investigators Unravel Biological Roots of Pulmonary Hypertension
Working with cells that line the innermost layer of the blood vessels, Johns Hopkins investigators say they have made a leap forward in understanding the underlying biology behind pulmonary hypertension, a dangerous type... read more
The Emerging Role of the Microbiota in the ICU
The importance of the intestinal and lung microbiotas is often overlooked on the ICU. Currently, we can explore the microbiome using a vast array of techniques, giving us 'meta' libraries of data, which has allowed researchers... read more
New Approach Developed for Diagnosing COPD
Primary care clinicians may soon be able to provide an early diagnosis for chronic obstructive pulmonary disease, or COPD, using a new method. According to researchers, patients with COPD can be diagnosed with the help of... read more
Sepsis-3, a New Definition. Solutions or New Problems?
Before we can discuss the "Sepsis-3" definitions, we need to look back at the history of Sepsis definitions, and what the rationale was leading the authors to create a new definition. Below is a brief, albeit non-exhaustive,... read more
Critical Care Reviews Book 2018
The Critical Care Reviews Book summarises, critiques and puts in context the biggest trials of the year. Five intensivists from Belfast, Northern Ireland, spend a year writing this in their own time. This is available as... read more
Precision Medicine, Genome Sequencing, and Improved Population Health
Despite controversy, major health systems across the globe are obtaining and making use of genome sequence data in patients they care for, hoping this approach will prove beneficial.1 Genome sequencing technology, a key driver... read more
Helping Without Harming
You've been resuscitating the patient for hours and finally caught up with volume. You come back on your next shift only to find your colleague has been diuresing them all day. What the heck were they thinking!?! This normal... read more
Does Respiratory Variation Of Inferior Vena Cava Diameter Predict Fluid Responsiveness In Spontaneously Ventilating Children With Sepsis
IVC collapsibility has poor test characteristics for predicting fluid responsiveness in spontaneously ventilating children with sepsis. Thirty-nine fluid boluses were recorded in 33 children, 28/39 (72%) of which met criteria... read more
Efficacy of Combined Intravenous Thrombolysis and Thrombectomy
Mechanical thrombectomy (MT) improves clinical outcomes in patients with acute ischemic stroke (AIS) caused by a large vessel occlusion. However, it is not known whether intravenous thrombolysis (IVT) is of added benefit... read more
Updated Version of the Confusion Assessment Method for the ICU
The 2014 updated version of the CAM-ICU is valid according to DSM-5 criteria and reliable regarding inter-observer agreement in a research setting. Delirium remains under-recognized by bedside clinicians. Delirium was diagnosed... read more
Interprofessional Care and Teamwork in the ICU
A robust body of evidence supports an interprofessional approach as a key component in the provision of high-quality critical care to patients of increasing complexity and with increasingly diverse needs. "Interprofessional... read more
Improving Survival Rates From Sepsis
Sepsis kills more Australians each year than breast cancer and prostate cancer combined. Daily, as many as 20,000 people worldwide are thought to die from this deadly disease. Also known as blood poisoning, sepsis is a life-threatening... read more
