Tag: research
Single IRBs in Multisite Trials
On June 21, 2016, the US government announced changes that are arguably the most significant of the last quarter century concerning the protection of human research participants - a requirement for use of central or single... read more
NIH Consortium to Study Biomarkers for Dementia
A new National Institutes of Health (NIH) funded consortium will work to identify and validate trial-ready biomarkers for small vessel diseases in the brain that contribute to cognitive impairment and dementia. Seven participating... read more
The impact of oral care on oral health status and prevention of VAP in critically ill patients
Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections which increase mortality rate and length stay of hospitalization. Oral care would not only improve patient’s oral health and well-being,... read more
Big Data Detects Sepsis In Major Hospitals
Data analytics have found that large medical facilities have higher rates of death from sepsis than their smaller hospital counterparts. Researchers from Houston Methodist Hospital recently used Big Data analytics to learn... read more
Fluid resuscitation in human sepsis: Time to rewrite history
Fluid resuscitation continues to be recommended as the first-line resuscitative therapy for all patients with severe sepsis and septic shock. The current acceptance of the therapy is based in part on long history and familiarity... read more
No Major Azithromycin Arrhythmia Risk in Huge European Cohort
Current use of azithromycin (Zithromax/Zmax, Pfizer) was linked with a twofold increased risk of ventricular arrhythmia compared with no antibiotic use, but this risk disappeared when azithromycin use was compared with amoxicillin... read more
Clinical summaries for hospitalised patients: time for higher standards
The average person remembers less than half of the information provided by healthcare professionals during a medical visit. The situation is arguably most challenging for patients leaving the hospital, where acute illness,... read more
Mindfulness Program Aims to Help Nurses Better Manage Stress
Creating a nursing workforce that is resilient to occupational stress and burnout is critical for engagement, job satisfaction and retention, as well as the overall success of any healthcare organization. The overall goal... read more
Early Palliative Care in Advanced Illness
As the on-call pulmonary critical care fellow, I listened to a family member plead with me to "do right by Mama." The emergency department team consulted me for possible intensive care unit (ICU) admission on a... read more
The Confusion Assessment Method for the ICU-7 Delirium Severity Scale
Delirium severity is independently associated with longer hospital stays, nursing home placement, and death in patients outside the ICU. Delirium severity in the ICU is not routinely measured because the available instruments... read more
Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management
Spontaneous respiratory effort during mechanical ventilation has long been recognized to improve oxygenation, and because oxygenation is a key management target, such effort may seem beneficial. Also, disuse and loss of peripheral... read more
Many Factors Contribute to Nurses' Alarm Response Time
Multiple factors including nurses' experience and assignments determined how fast they responded when monitoring alarms were triggered in a children's hospital, a video analysis found. Nurses were more likely to... read more
Changing Mindsets to Enhance Treatment Effectiveness
This Viewpoint defines mindsets - frames of mind that orient beliefs or expectations - discusses how they can influence patients' perceptions about treatment and self-efficacy, and proposes ways physicians might shape... read more
Building Global Collaboration in Acute Care Research
Dr. Ludwig Lin, MD, speaks with John C. Marshall, MD, FRCSC, FACS, about his talk given at the 46th Critical Care Congress in Honolulu, Hawaii on, "Building Global Collaboration in Acute Care Research." Dr. Marshall discusses... read more
Communicating Context in Quality Improvement Reports
The study by Demb and colleagues reports on the positive results of an intervention strategy to reduce excess radiation exposure across 5 academic medical centers associated with the University of California. Leading up to... read more
The Prevalence of Acute Critical Neurological Disease in Children
Neurologic insults are a significant pediatric international health issue. They are frequent and contribute substantial morbidity and mortality. These data suggest a need for an increased focus on acute critical neurologic... read more
Association between delirium superimposed on dementia and mortality in hospitalized older adults
In a prospective cohort study, Thiago Junqueira Avelino-Silva and colleagues examine the association of delirium superimposed on dementia on hospital mortality and 12-month mortality in hospitalized older adults. This was... read more
Intraoperative Oxidative Stress Associated With Postoperative Delirium
Intraoperative oxidative stress is associated with postoperative delirium in ICU patients after cardiac surgery, a study has found. Researchers from Vanderbilt University Medical Center, in Nashville, Tenn., came to this... read more
Anesthesiologists Found Underreporting Medication Errors
Medication errors are apparently significantly underreported by anesthesia providers, at least at certain institutions. These recent findings may reflect a culture of underreporting or fear of punitive action, despite the... read more
ICU Study Shows Significant Reduction in Time to Blood Gas Result using Sphere Medical’s Proxima
A recent time and motion study by University Hospital Southampton demonstrated a 1.5 minute (>20%) reduction in time to blood gas results when using the Proxima bedside blood gas monitoring system. The study also found... read more
How Redesigning The Abrasive Alarms Of Hospital Soundscapes Can Save Lives
After a recent hospital stay filled with frightening, uselessly beeping gadgets, an ambient musician set to work reinventing the aural landscape of medicine, to make life calmer for patients and easier for doctors. ... read more
How to keep up with the scientific literature
Few aspects of scientific work may be as crucial - and yet as easy to neglect - as reading the literature. Beginning a new research project or writing a grant application can be good opportunities for extensive literature... read more
