Tag: research
The fragility index in randomised controlled trials of interventions for aneurysmal subarachnoid hemorrhage
Fragility analysis supplements the p-value and risk of bias assessment in the interpretation of results of randomised controlled trials. In this systematic review we determine the fragility index (FI) and fragility quotient... read more
RECOVERY trial shows tocilizumab reduces deaths in patients hospitalised with COVID-19
The NIHR-supported RECOVERY trial has shown that tocilizumab - an anti-inflammatory rheumatoid arthritis treatment - reduces the risk of death for hospitalised patients with severe COVID-19. Researchers also found that... read more
FDA Limits Use of Convalescent Plasma as COVID-19 Treatment
The Food and Drug Administration (FDA) is scaling back its authorization of the use of convalescent blood-plasma for COVID-19 patients in an effort to guide physicians who have faced a confusing thicket of data about the... read more
Nebulised heparin for patients with or at risk of ARDS
In patients with or at risk of acute respiratory distress syndrome (ARDS), nebulised heparin did not improve self-reported performance of daily physical activities, but was well tolerated and exploratory outcomes suggest... read more
Inflammatory Response and Phenotyping in SARI From the MERS Coronavirus
One third of critically ill patients with Middle East respiratory syndrome (MERS) severe acute respiratory infection (SARI) and non-Middle East respiratory syndrome severe acute respiratory infection demonstrated a subphenotype... read more
Barriers to reporting guideline adherence in POCUS research
Although investigators and editors recognise the importance of completely reported research, reporting quality is still a core issue for point-of-care ultrasound (POCUS) research. The shared opinion held by investigators... read more
Antimicrobial‑associated Harm in Critical Care
The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents. Antimicrobial... read more
Harnessing a Pioneering Cell Therapy Treatment for COVID-19 Patients with ARF
A world-leading UK-wide trial supported by NIHR is offering a pioneering cell therapy treatment for patients with acute respiratory failure (ARF) caused by COVID-19. The groundbreaking study, led by experts at Queen's... read more
From the Exposome to the Socioexposome in COVID-19 Research
The coronavirus disease 2019 (COVID-19) pandemic continues to expose how access to health care and delivery of care are important concerns, second only to the primary concern regarding exposure to the severe acute respiratory... read more
ICU Delirium-Prediction Models: A Systematic Review
Although most ICU delirium-prediction models have relatively good performance, they have limited applicability to clinical practice. Most models were static, making predictions based on data collected at a single time-point,... read more
The voice of people living with COPD: what I learned from doing qualitative research
As a general respiratory physician, schooled in the clinical world of evidence-based medicine (EBM), I shared a common view that qualitative research was, well, flaky. Where was the science? The statistical significance?... read more
Changes in Drug List Prices and Amounts Paid by Patients and Insurers
In this cross-sectional study, we found that increases in drug wholesale list prices are associated with increases in net patient out-of-pocket costs and insurer payments. This finding suggests that, although discounts and... read more
Response to optic nerve sheath diameter guided detection of sepsis associated encephalopathy
regarding the blind method, being uninformed of the clinical diagnoses of patients is unavailing, since clues will still be found in patients' clinical manifestations. Therefore, two trained physicians in intensive ultrasound... read more
Caring for the Sickest COVID-19 Patients: An ICU Story
In an article for the latest issue of Stanford Medicine magazine, I provide a glimpse into the journey Free and his front-line Stanford Health Care colleagues took -- from Day 1 through the following weeks and months -- to... read more
Expert Consensus on Methodology for Conducting and Reporting Echocardiography Research Studies
Echocardiography is a common tool for cardiac and hemodynamic assessments in critical care research. However, interpretation (and applications) of results and between-study comparisons are often difficult due to the lack... read more
Prior Routine Use of NSAIDs and Important Outcomes in Hospitalised COVID-19 Patients
Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory... read more
Resilience in a Prehospital Setting – A New Focus for Future Research?
Empirical research is of crucial importance to understand, build and support resilient systems and processes, including exploring and developing interventions to improve capacity for adaptive change in a prehospital setting. Handling... read more
