Resuscitation with Blood Products in Patients with Trauma-related Hemorrhagic Shock Receiving Prehospital Care

The trial did not show that prehospital PRBC–LyoPlas resuscitation was superior to 0·9% sodium chloride for adult patients with trauma related hemorrhagic shock. Further research is required to identify the characteristics... read more

Pediatric Pneumonia Research Priorities in the Context of COVID-19

Operational research on health system capacities, and evaluating optimized delivery of existing treatments, diagnostics and case management approaches are needed. This list should act as a catalyst for collaborative research,... read more

Cardiovascular Complications of COVID-19: Risk, Pathogenesis and Outcomes

This book discusses the evidence behind the relationship between COVID-19 and heart disease based on emerging state-of-the-art data. The rapid and unexpected global spread of the COVID-19 has revealed proportional levels... read more

Cardiovascular Complications of COVID-19: Risk, Pathogenesis and Outcomes

Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia

Advances in perinatal care have dramatically improved survival of extremely preterm infants and the incidence of bronchopulmonary dysplasia (BPD) has not changed over the past few decades, which likely reflects the impact... read more

Immunotherapy

The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types... read more

Immunotherapy

Antiviral Drug Discovery and Development

This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced... read more

Antiviral Drug Discovery and Development

Defining COVID-19 Associated Pulmonary Aspergillosis

The reported prevalence of CAPA in ICU patients with COVID-19 varies greatly by study and may be related to surveillance protocols and inconsistent definitions which may inflate the prevalence of this complication. Further... read more

Intravenous Vitamin C Administration to Septic Shock Patients

Our pilot study indicated that intravenous vitamin C did not provide significant decreases in the mean dose or duration of vasopressor infusion. Further research that takes into account the potential impact of intervention... read more

Guidelines on Temperature Control After Cardiac Arrest in Adults

The aim of these guidelines is to provide evidence‑based guidance for temperature control in adults who are coma‑tose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying... read more

Equipotent Ratios for the Most Common Vasopressors

Calculating equipotent doses between vasopressor agents is necessary in clinical practice and research pertaining to the management of shock. This scoping review summarizes conversion ratios between vasopressors and provides... read more

ERC-ESICM Guidelines on Temperature Control After Cardiac Arrest in Adults

The aim of these guidelines is to provide evidence‑based guidance for temperature control in adults who are comatose after resuscitation from either in-hospital or out-of-hospital cardiac arrest, regardless of the underlying... read more

Inhaled Corticosteroid Use on COVID-19 Outcomes Among Hospitalized Adult Asthmatics

While our findings confirm trends observed by others with respect to risk factors among asthmatics with COVID-19, differences based on sex, ethnicity and ICS use in asthmatics were observed. Our finding that ICS use was associated... read more

Study Supports Remdesivir Treatment for COVID-19 Patients on Low-Flow Oxygen or No Oxygen

Remdesivir treatment increased the likelihood of clinical improvement in COVID-19 patients on low-flow oxygen or no oxygen, according to a new study by the Johns Hopkins University School of Medicine, the Johns Hopkins Bloomberg... read more

Long-Term Opioid Prescription Linked to Higher Risk of Hepatitis C

Exposure to long-term prescription opioid therapy was linked to a three times higher risk of HCV seroconversion compared to individuals who were prescription opioid-naïve or acute. Prescription opioid use is associated... read more

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission... read more

Descriptors of Sepsis Using the Sepsis-3 Criteria

We successfully operationalized the Sepsis-3 criteria to an electronic health record dataset to describe the characteristics of critical care patients with sepsis. This may facilitate sepsis research using electronic health... read more

HSV-1 Reactivation Associated with Increased Mortality Risk and Pneumonia in COVID-19 Patients

Critically ill COVID-19 patients frequently reactivate HSV-1 but not HSV-2. HSV-1 reactivation in critically ill COVID-19 patients was associated with an increased risk of day-60 mortality and hospital-acquired pneumonia... read more

Cancer Clues In A Drop Of Blood

New diagnostic blood test paves the way for early stage lung cancer screening. A diagnostic blood test may provide early detection of lung cancer in asymptomatic patients, according to a new study. Lung cancer, the leading... read more

Clinical Synopsis of COVID-19: Evolving and Challenging

Coronavirus disease or COVID-19 or SARS-CoV-2 infection is the latest pandemic that has affected humans globally. The disease has manifested itself in several forms and is now the focus of research worldwide. This book... read more

Clinical Synopsis of COVID-19: Evolving and Challenging

Identification of Biomarkers, New Treatments, and Vaccines for COVID-19

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are... read more

Identification of Biomarkers, New Treatments, and Vaccines for COVID-19

Semiquantitative Assessment of RFV with a Modified Subcostal Echocardiographic View

In patients presenting with RVF in the ICU (or in situations where the apical echocardiographic view is suboptimal for tricuspid annular assessment), SEATAK can be an alternative to TAPSE. Further research is needed to validate... read more

Post COVID-19 and Patients with and without Pre-existing ILD

A lot remains to be learned about the long-term effects of patients with interstitial lung disease (ILD) who survive COVID-19 infections. Clinicians need to better understand and recognize the effects of post-COVID 19 lung... read more