Perceived Barriers to Rapid Response Team Activation Among Nurses

The purpose of this literature review was to investigate the major barriers nurses face when it is necessary to seek additional assistance and resources by calling the rapid response team (RRT) in order to manage and stabilize... read more

Perceived Barriers to Rapid Response Team Activation Among Nurses

AKI in Critically Ill Patients with COVID-19

Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with high mortality rates in this setting,... read more

AKI in Critically Ill Patients with COVID-19

Low-dose Dopamine in Patients with Early Renal Dysfunction

Administration of low-dose dopamine by continuous intravenous infusion to critically ill patients at risk of renal failure does not confer clinically significant protection from renal dysfunction. The groups assigned dopamine... read more

Low-dose Dopamine in Patients with Early Renal Dysfunction

Correction and Control of Hyperammonemia in Acute Liver Failure

Continuous renal replacement therapy (CRRT) is associated with reduced ammonia concentrations in acute liver failure patients. This effect is related to greater cumulative dose. These findings suggest that continuous... read more

Correction and Control of Hyperammonemia in Acute Liver Failure

Intravenous Fluid Therapy in Critically Ill Adults

Despite the administration of intravenous fluids to critically ill patients being a near-universal intervention, the available evidence base guiding their safe and appropriate use is scarce and derived mainly from academically... read more

Intravenous Fluid Therapy in Critically Ill Adults

Serum Lactate Level and Mortality in Metformin-associated Lactic Acidosis Requiring RRT

This study suggests that predialysis level of serum lactate level is an important marker of mortality in MALA patients requiring renal replacement therapy (RRT) with a linear dose-response relationship. To better evaluate... read more

Serum Lactate Level and Mortality in Metformin-associated Lactic Acidosis Requiring RRT

Distance Between the Tips of Central Venous Catheters Does Not Depend on Same or Opposite Site Access

Central venous catheters (CVCs) are routinely required in the intensive care unit (ICU) for infusion of drugs, often concurrently with central venous dialysis catheters (CVDCs) for renal replacement therapy (RRT). Increased... read more

Distance Between the Tips of Central Venous Catheters Does Not Depend on Same or Opposite Site Access

Association Between Intravenous Contrast Media Exposure and Non-recovery From Dialysis-requiring Septic AKI

This large observational study did not support an association between intravenous contrast media and adverse in-hospital outcomes in patients with septic dialysis-requiring acute kidney injury (AKI-D). Further studies are... read more

Association Between Intravenous Contrast Media Exposure and Non-recovery From Dialysis-requiring Septic AKI

Risk for Mortality in Critically Ill Children Needing RRT

Margaret M. Parker, MD, MCCM, speaks with Danny Hames, MD, on his article titled "Risk Factors for Mortality in Critically Ill Children Requiring Renal Replacement Therapy" published in the November 2019 issue of Pediatric... read more

Risk for Mortality in Critically Ill Children Needing RRT

Using Additional Pressure Control Lines When Connecting a Continuous RRT Device to an ECMO Circuit

The present study suggests that the use of additional tubing can be considered a simple and safe method for pressure control and improvement of filter survival when connecting a continuous renal replacement therapy (CRRT)... read more

Using Additional Pressure Control Lines When Connecting a Continuous RRT Device to an ECMO Circuit

Fluid Resuscitation: Evidence-based Solutions?

Intravenous (IV) fluid prescribing is one of the commonest tasks carried out by junior doctors. I still remember around this time last year when I was fresh out of medical school and had just been let loose on the wards,... read more

Fluid Resuscitation: Evidence-based Solutions?

Low-dose Atrial Natriuretic Peptide for Prevention or Treatment of AKI

Theoretically, atrial natriuretic peptide (ANP), especially low-dose ANP, is beneficial in acute kidney injury (AKI). In this study, we examined whether low-dose ANP is effective in preventing or treating AKI by conducting... read more

Low-dose Atrial Natriuretic Peptide for Prevention or Treatment of AKI

Oxalate Nephropathy Following Vitamin C Intake within ICU

Compelling evidence obtained from in-vitro and animal studies suggest that vitamin C, a circulating antioxidant, may be a valuable adjunctive therapy in critically-ill patients. Data from humans are more conflicting.... read more

Oxalate Nephropathy Following Vitamin C Intake within ICU

Balanced Crystalloids vs. Saline in Critically Ill Adults

Among critically ill adults, the use of balanced crystalloids for intravenous fluid administration resulted in a lower rate of the composite outcome of death from any cause, new renal-replacement therapy, or persistent renal... read more

Balanced Crystalloids vs. Saline in Critically Ill Adults

Fluid Resuscitation with PPD Attenuates Crush Injury-related AKI and Improves Survival

In-hospital renal replacement therapy (RRT) is widely used for the treatments of acute kidney injury (AKI) in crush injury (CI) victims. This study was designed to investigate whether preventive peritoneal dialysis (PPD)... read more

Fluid Resuscitation with PPD Attenuates Crush Injury-related AKI and Improves Survival

Early Mobilization on CRRT is Safe and May Improve Filter Life

Despite studies demonstrating benefit, patients with femoral vascular catheters placed for continuous renal replacement therapy (CRRT) are frequently restricted from mobilization. No researchers have reported filter pressures... read more

Early Mobilization on CRRT is Safe and May Improve Filter Life

Effects of Baseline Thrombocytopenia and Platelet Decrease Following RRT Initiation in Patients With Severe AKI

Baseline thrombocytopenia and platelet decrease following renal replacement therapy initiation were associated with increased mortality, and baseline thrombocytopenia was associated with decreased rates of renal recovery.... read more

Effects of Baseline Thrombocytopenia and Platelet Decrease Following RRT Initiation in Patients With Severe AKI

Identifying At-Risk Patients for Sub-optimal Beta-lactam Exposure in Critically Ill Patients with Severe Infections

Conventional beta-lactam dosing is flawed in critically ill patients. Useful tools such as the MeroRisk Calculator need to be comprehensively evaluated clinically, and if successful should be added into clinical practice... read more

Identifying At-Risk Patients for Sub-optimal Beta-lactam Exposure in Critically Ill Patients with Severe Infections

Sedation in the ICU – Good Past – Better Future?

The concepts for good sedation include defining the range of sedation, the need for agents with rapid response that can be easily and rapidly varied in restless and confused patients, various modes of ventilation, continuous... read more

Sedation in the ICU – Good Past – Better Future?

A Positive Fluid Balance is an Independent Prognostic Factor in Patients with Sepsis

Intravenous fluid administration is an essential component of sepsis management, but a positive fluid balance has been associated with worse prognosis. We analyzed whether a positive fluid balance and its persistence over... read more

A Positive Fluid Balance is an Independent Prognostic Factor in Patients with Sepsis

Continuous RRT – Understanding Circuit Hemodynamics to Improve Therapy Adequacy

The utilization of continuous renal replacement therapy (CRRT) increases throughout the world. Technological improvements have made its administration easier and safer. However, CRRT remains associated with numerous pitfalls... read more

Continuous RRT – Understanding Circuit Hemodynamics to Improve Therapy Adequacy