Tag: sepsis
Triumph Over Sepsis: Dramatic Mortality Decline in ANZ ICUs, With a Post-2020 Rebound
In a comprehensive analysis of over 2.9 million ICU admissions across 219 Australian and New Zealand intensive care units from 2000 to mid-2023, in-hospital mortality for adult patients with sepsis (per Sepsis-3 criteria)... read more
Vasopressin in Septic Shock: When and How to Use the Second-Line Vasopressor
SSC Guideline Recommendation: The Surviving Sepsis Campaign (SSC) weakly recommends adding vasopressin as a second-line agent instead of continuously escalating norepinephrine if a patient's mean arterial pressure (MAP) remains... read more
Protocol Power: Code Sepsis Boosts Bundle Compliance and Cuts Hospital Stays
Study Design: This was a retrospective, single-center study comparing patients with severe sepsis or septic shock before (Pre-Code Sepsis, PC) and after (After-Code Sepsis, AC) the implementation of a structured, team-based... read more
Reducing Mortality in Critically Ill Patients
This book describes the techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill patients, defined as those who have acute failure of at least... read more
Predicting Sepsis Mortality: The Power of NLR and PCT Clearance
A retrospective cohort study analyzed the dynamic changes of several inflammatory biomarkers to predict mortality in 64 Intensive Care Unit (ICU) patients diagnosed with sepsis. The study, which collected clinical and... read more
Critical Care Pearls: ICU Q&A Handbook for Critical Care Medicine: A Board Review and Daily Clinical Practice. Rapid Reference for Physicians, Fellows & Nurses
In the fast-paced world of intensive care medicine, every second counts and every question matters. Critical Care Pearls – Third Edition delivers over a thousand carefully curated ICU questions and evidence-based answers... read more
Critical Care Nursing Mnemonics: A Fast Recall Guide for ICU and Emergency Nurses
In the world of critical care and emergency nursing, seconds matter—and knowledge must be ready on demand. Critical Care Nursing Mnemonics is your compact, clinical companion designed to help ICU and ER nurses recall essential... read more
Nutrition in ICU Patients
This book discusses practical topics in critical care nutrition including basic principles and practices in nutrition support in the ICU. Tailoring nutrition solutions is crucial for the development and prognosis of critical... read more
Critical Care & ICU Made Simple: The Illustrated Bedside Manual for Fast Decision-Making and Real-World Patient Management
Are you overwhelmed by complex ICU textbooks that make critical care harder, not easier? Do you wish you had a practical critical care handbook that helps you make the right call in seconds, not hours? You’ve just found... read more
AI Spots Deadly Sepsis Clotting Crisis Hours Earlier – Now Live as a Free Web Tool
In a large multi-center retrospective study using the MIMIC-IV and eICU-CRD databases, researchers developed an interpretable machine learning model to predict sepsis-induced coagulopathy (SIC) within 7 days of ICU admission.... read more
Lungs Hit Hardest: Respiratory Sepsis Survivors Face Sharply Higher Death Rates and Cognitive Decline Years Later
In a large cohort study of 12,854 ICU survivors in Germany, patients who survived respiratory sepsis (RS) – mostly from bacterial pneumonia – had significantly worse long-term outcomes than those who survived SARS-CoV-2... read more
Copine 5: A Key Defender Against Sepsis’s Deadly Leak
This study identifies Copine 5 (CPNE5) as a critical factor in the development of life-threatening sepsis-induced vascular leakage and mortality. Analysis of human aorta cells revealed that CPNE5 is the primary Copine family... read more
Sepsis Heart Mystery: Is Myocardial Dysfunction a Killer or Just a Sign of Sickness?
Sepsis-induced myocardial dysfunction (SIMD) is a common and clinically significant complication in critically ill patients with sepsis and septic shock. This systematic review confirms that SIMD is consistently linked to... read more
ICU Alert: Unraveling Mortality in Obstructive Pyelonephritis
This retrospective multicenter study investigated in-hospital mortality among 483 patients admitted to the ICU (8 centers) over a decade due to obstructive pyelonephritis, a severe condition often caused by kidney stones,... read more
Handbook of Evidence-Based Critical Care
This updated and revised edition of the classic bedside pocket reference remains the gold standard in critical care medicine. The new edition maintains Dr. Marik's trademark humor and engaging writing style, while adding... read more
VA-ECMO in Septic Shock: A High-Stakes, High-Uncertainty Rescue
The use of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) as a rescue therapy for refractory septic shock remains a challenging, context-dependent, and uncertain strategy in adults. Current evidence shows... read more
Defending the Vulnerable: Neutropenic Sepsis Outcomes Improve Despite Higher Risk
A decade-long, single-center study in a French ICU examined the characteristics and outcomes of 185 consecutive patients admitted with neutropenic sepsis or septic shock between 2012 and 2022. The analysis revealed a... read more
SOFA-2: Close, But Not Quite the Ideal Measure of Organ Failure
The SOFA-2 (Sequential Organ Failure Assessment) score represents the latest effort to provide a simple, reliable, and continuous measure of organ dysfunction in critically ill patients, a concept first outlined decades ago.... read more
Beyond Liver Failure: MELD-XI Predicts Sepsis Mortality
This retrospective cohort study investigated the utility of the MELD-XI (Model for End-Stage Liver Disease-Excluding INR) score as a predictor of 30-day mortality in over 16,600 adult ICU patients with sepsis, using data... read more
The Sepsis Chain of Survival: Breaking the Cycle
This framework offers a systematic and adaptable approach to improving outcomes for patients with suspected sepsis. Borrowing from the successful Cardiac Arrest Chain of Survival, the Sepsis Chain emphasizes a seamless series... read more
Management of Dysregulated Immune Response in the Critically Ill
This book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, deals with dysregulated host response a relatively new term introduced by the Sepsis-3 definitions in 2016. In contrast to systemic... read more
Corticosteroids in ARDS: Delaying High-Dose Methylprednisolone Doesn’t Kill
This large retrospective study investigated whether starting high-dose (2 mg/kg) methylprednisolone therapy after 14 days of Acute Respiratory Distress Syndrome (ARDS) onset increased the risk of complications or mortality... read more
