Tag: sepsis
The ADRENAL Trial: Steroids in Septic Shock
Randomized clinical trials evaluating the efficacy of adjunctive corticosteroids in septic shock have shown conflicting evidence of clinical relevance. Two trials in particular looked at lower dose hydrocortisone (200mg/day)... read more
Defining Sepsis on the Wards: Comparing Two Sepsis Definitions
Sepsis is defined as a dysregulated host response to infection, resulting in acute organ dysfunction. Although the condition has been thoroughly studied in the intensive care unit (ICU), accurate data collection outside of... read more
The 2018-2023 World Outlook for Sepsis Drugs
This study covers the world outlook for sepsis drugs across more than 190 countries. For each year reported, estimates are given for the latent demand, or potential industry earnings (P.I.E.), for the country in question... read more
Importance of Second Antibiotic Doses in ED Sepsis Patients
Most studies evaluating early antibiotic administration in sepsis patients focus on timing of the first dose. We highlight many of these studies in our recent review article on Appropriate Antibiotic Therapy in Emergency... read more
Is Fever the Normal Temperature of Sepsis
We know that hypothermia in sepsis is associated with increased mortality but other than that we tend to see fever in sepsis as something bad. We tend to perceive sepsis patients as more sick the more the temperature is elevated.... read more
Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock
Targeting higher blood pressure targets may increase mortality in patients who have been treated with vasopressors for more than 6 h. Lower blood pressure targets were not associated with patient‑important adverse events... read more
Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
Among patients with septic shock undergoing mechanical ventilation, a continuous infusion of hydrocortisone did not result in lower 90-day mortality than placebo. We randomly assigned patients with septic shock who were undergoing... read more
Should We Manage All Septic Patients Based on a Single Definition?
It is indisputable from the biological and clinical perspectives that not all cases of sepsis are the same. On the contrary, most have great many differences, that is, different portals of entry, clinical manifestations,... read more
Hypothermia in Sepsis – The CASS Trial
Sepsis and especially septic shock (no matter what definition you use) is a recipe for multi-organ dysfunction and poor prognosis. In the past few years, we saw a lot of failed attempts trying to find something that could... read more
I survived sepsis eight times. But can care workers spot this deadly illness?
Care staff are increasingly likely to see sepsis, but there is no standard training to make them aware of the symptoms to look out for in clients. There is a golden hour for the treatment of sepsis, when someone can be saved... read more
Acute Kidney Injury in Sepsis
Acute kidney injury (AKI) and sepsis carry consensus definitions. The simultaneous presence of both identifies septic AKI. Septic AKI is the most common AKI syndrome in ICU and accounts for approximately half of all such... read more
Sepsis Early Warning Score Adopted in UK
Every NHS hospital trust in England will be asked to adopt a new clinical system for assessing acutely ill patients. The National Early Warning Score (NEWS), developed by the Royal College of Physicians (RCP) in 2012, has... read more
Surviving Sepsis
This audio documentary takes a glimpse into the lives of those that have survived the unimaginable.... read more
Initial Crystalloid Resuscitation in Sepsis and Septic Shock
Ludwig Lin, MD, speaks with Daniel E. Leisman, BS, about the article, "Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort," published in Critical... read more
Machine Learning Model Predicts Sepsis in ICU Patients 12 Hours Before Diagnosis
A machine learning model accurately predicted the onset of sepsis in ICU patients four to 12 hours prior to clinical recognition in a recent study. The observational cohort study used data from more than 31,000 admissions... read more
The EM Educator Series: Sepsis in the ED
These posts provide brief mini-cases followed by key questions to consider while working. The featured questions provide important learning points for those working with you, as well as vital items to consider in the evaluation... read more
Chloride and Other Electrolyte Concentrations in Commonly Available 5% Albumin Products
This study is the first to identify and document a statistically significant variability in the chloride concentration of available 5% albumin products. This study has also informed a pilot randomized controlled trial examining... read more
Healthcare Utilization and Infection in the Week Prior to Sepsis Hospitalization
Over 45% of sepsis patients had clinician-based encounters in the week prior to hospitalization with an increasing frequency of diagnoses for acute infection and antibiotic use in the outpatient setting. These presepsis encounters... read more
Probiotics Offer Powerful Protection Against Sepsis in Infants
Sepsis can occur in just about anyone, including infants. Recent research shows feeding newborns probiotics (healthy bacteria) significantly lowers the child's risk of developing sepsis. The study involved infants in rural... read more
Enhancing Recovery From Sepsis
Survival from sepsis has improved in recent years, resulting in an increasing number of patients who have survived sepsis treatment. Current sepsis guidelines do not provide guidance on posthospital care or recovery. In the... read more
Serum Lactate Upon Emergency Department Arrival as Predictor of 30-day In-Hospital Mortality
Despite of numerous evidences that elevated serum lactate levels were associated with unfavorable outcomes, there have been no study demonstrated an optimal cutoff of serum lactate in unselected patients. This study was aimed... read more
Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock
The guideline recommendations showed that shorter delays indicates better outcomes. There was no evidence that 3 hours is safe; even very short delays adversely impact outcomes. Findings demonstrated a new approach to incorporate... read more
