Tag: sepsis
Addressing Sepsis – Video Recap of the WHA Side Event on Sepsis
On the occasion of the World Health Assembly passing a resolution on sepsis, the Global Sepsis Alliance, IAPO, and the German Federal Ministry of Health have hosted the "WHA Side Event on Sepsis" in Geneva on May... read more
Generalizable Biomarkers in Critical Care
The sequencing of the human genome and the subsequent availability of inexpensive, robust methods for "omics" profiling (e.g., genome-wide association studies, gene expression microarrays, and metabolomics) have... read more
Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock
The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine... read more
Diagnostic work-up and specific causes of acute kidney injury
Acute kidney injury (AKI) is common in critically ill patients and associated with grim short- and long-term outcome. Although in the vast majority of cases AKI is multifactorial, with sepsis, shock and nephrotoxicity accounting... read more
Albumin Administration in Sepsis: The Case for and Against
Serum albumin is an essential plasma protein, with a variety of homeostatic and predictive roles in health and disease. Hypoalbuminaemia is common in critical illness. Human albumin solution has been administered clinically... read more
Implications of Prevalent Noncardiac Disease in the Cardiac ICU
Half of >1000 patients of admitted to the cardiac intensive care unit (ICU) at a major tertiary-care center over about 1 year also had acute respiratory failure, acute kidney injury, or sepsis. Those with lung or kidney... read more
Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients
Objectives: To prospectively validate that the inability to decrease procalcitonin levels by more than 80% between baseline and day 4 is associated with increased 28-day all-cause mortality in a large sepsis patient population... read more
Clinical Sensors lands $1.5 million in NIH grants for sepsis work
Clinical Sensors, a startup based in Research Triangle Park, North Carolina, has been awarded two Small Business Research Grants from the National Institutes of Health. Together, the grants total $1.5 million and are earmarked... read more
Big Data Detects Sepsis In Major Hospitals
Data analytics have found that large medical facilities have higher rates of death from sepsis than their smaller hospital counterparts. Researchers from Houston Methodist Hospital recently used Big Data analytics to learn... read more
Fluid resuscitation in human sepsis: Time to rewrite history
Fluid resuscitation continues to be recommended as the first-line resuscitative therapy for all patients with severe sepsis and septic shock. The current acceptance of the therapy is based in part on long history and familiarity... read more
Evaluating the Validity of Sepsis-3 Criteria in the Emergency Department
In this multicenter prospective cohort study involving 879 patients with suspected infection treated at the emergency department, the qSOFA was better at predicting in-hospital mortality with an area under the receiver operating... read more
Antipyretic Therapy in Critically Ill Septic Patients
This meta-analysis aimed to examine the impact of antipyretic therapy on mortality in critically ill septic adults. Inclusion criteria were observational or randomized studies of septic patients, evaluation of antipyretic... read more
Venous congestion: are we adding insult to kidney injury in sepsis?
In critical illness, septic shock is a contributing factor in nearly half of all cases of acute kidney injury (AKI). Traditional approaches to prevention of organ dysfunction in early sepsis have focused on prevention of... read more
Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound
Cationic antimicrobial peptides are multifunctional molecules that have a high potential as therapeutic agents. We have identified a histone H1-derived peptide from the Komodo dragon (Varanus komodoensis), called VK25. Using... read more
The impact of emergency department crowding on early interventions and mortality in patients with severe sepsis
Critically ill patients require significant time and care coordination in the emergency department (ED). We hypothesized that ED crowding would delay time to intravenous fluids and antibiotics, decrease utilization of protocolized... read more
Relative Bradycardia in Patients With Septic Shock Requiring
Relative bradycardia in patients with septic shock is associated with lower mortality, even after adjustment for confounding. Our data support expanded investigation into whether inducing relative bradycardia will benefit... read more
Meta-analysis confirms EGDT for sepsis is unhelpful and wasteful (PRISM)
Three large, well-conducted randomized trials around the world (ProCESS, ARISE, and ProMISe) all agreed: use of early goal-directed therapy (EGDT) for sepsis does not improve mortality or any other important clinical outcome.... read more
Early, Goal-Directed Therapy for Septic Shock
After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This... read more
Surviving Sepsis Campaign Guidelines: 2016 Update
Ludwig Lin, MD, speaks with Mitchell M. Levy, MD, MCCM, about the release of the "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016," presented at the 46th Critical Care Congress... read more
Vitamin C and the Ethics of Borrowing data
I was recently amazed to be engaged in a Twitter kerfuffle which generated more than 10,000 Impressions within 24 hours. Passions were running high, libellous comments were being broadcast, and old friendships seemed to be... read more
Predicting and measuring fluid responsiveness with echocardiography
Echocardiography is an essential tool to predict and measure fluid responsiveness, according to a recent article, which provides a practical guide. Ashley Miller and Justin Mandeville outline the physiological basis of fluid... read more
Doctor Turns Up Possible Treatment For Deadly Sepsis
It is hard not to get excited about news of a potentially effective treatment for sepsis, a condition that leads to multiple organ failure and kills more people in the hospital than any other disease. The study, from Eastern... read more
