Tag: sepsis
The Epidemiology of Hospital Death Following Pediatric Severe Sepsis
Margaret Parker, MD, MCCM, speaks with Scott L. Weiss, MD, MSCE, about the article, "The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die," published in the September... read more
The 10 False Beliefs in Adult Critical Care Nephrology
Acute tubular necrosis (ATN), a histological pattern observed after ischemic insult, is considered the most frequent cause of any form of acute kidney injury (AKI) despite the absence of extensive histological data. This... read more
Prehospital Antibiotics in the Ambulance for Sepsis
Emergency medical services (EMS) personnel have already made substantial contributions to improving care for patients with time-dependent illnesses, such as trauma and myocardial infarction. Patients with sepsis could also... read more
Tissue Edema, Fluid Balance, and Patient Outcomes in Severe Sepsis
Severe sepsis and septic shock remain among the deadliest diseases managed in the intensive care unit. Fluid resuscitation has been a mainstay of early treatment, but the deleterious effects of excessive fluid administration... read more
iSepsis – A 30ml/kg Bolus: Yes or No -The Results
The results of both surveys are not surprising. This recommendation has never been prospectively tested in a large RCT and has little supporting evidence. Imagine the American Heart Association (AHA) or the American Diabetes... read more
New Sepsis Definition (Sepsis-3) and Community-acquired Pneumonia Mortality
qSOFA and CRB outperformed SIRS and presented better clinical usefulness as prompt tools for patients with community-acquired pneumonia in the emergency department. Among the tools for a comprehensive patient assessment,... read more
Pearls and Pitfalls in Comprehensive Critical Care Echocardiography
Comprehensive critical care echocardiography is a useful, rapid and non-invasive method to both diagnose pathology and monitor treatment response in the critically ill. Although growing dramatically in use around the world,... read more
The Septic Shock 3.0 Definition and Trials
Ranjit Deshpande, MD, speaks with James A. Russell, MD, about the article, "The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience," published in the June 2017 issue of Critical Care Medicine.... read more
Sepsis mortality linked to concentration of critical care fellowships
Higher survival rates for sepsis were more concentrated in the Northeast and metropolitan areas in the Western regions of the United States. Compared with other parts of the United States, survival rates for sepsis were highest... read more
The Timing of Early Antibiotics and Hospital Mortality in Sepsis
Prior sepsis studies evaluating antibiotic timing have shown mixed results. Objective: To evaluate the association between antibiotic timing and mortality among sepsis patients receiving antibiotics within 6 hours of emergency... read more
Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold
Long-term mortality rates and HRQoL did not differ in patients with septic shock and anaemia who were transfused at a haemoglobin threshold of 7 g/dl versus a threshold of 9 g/dl. We may reject a more than 3 % increased hazard... read more
Updates on Sepsis from WSC
Fourth session from the World Sepsis Congress Spotlight: Maternal and Neonatal Sepsis - Updates on Sepsis.... read more
Platelets and Multi-Organ Failure in Sepsis
Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more... read more
Translational Evidence for Two Distinct Patterns of Neuroaxonal Injury in Sepsis
Ischemic and diffuse neuroaxonal injury to the brain in experimental sepsis, human postmortem brains, and in vivo MRI suggest these two distinct lesion types to be relevant. Future studies should be focused on body fluid... read more
2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis
Sepsis is a leading cause of death in the United States, but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on... read more
A Better Way to Detect Sepsis in Kids in the ED
We have been interested in this question for a long time here at CHOP and have done several interventions over the past several years to try to improve our ability to recognize children with septic shock. When we started... read more
Hospital admissions for sepsis jump 89% in Pennsylvania
The number of Lehigh Valley hospital admissions for sepsis, an increasingly prevalent life-threatening complication from infections, increased by 69 percent over eight years, according to a state report released Wednesday.... read more
Cellular Immunotherapy for Septic Shock
The infusion of freshly cultured allogenic bone marrow derived MSCs into participants with septic shock up to a dose of 3 million cells per kg (250 million cells) appears safe. Ages of participants in the interventional versus... read more
