COVID-19: A Message From Concerned Physicians

COVID-19: A Message From Concerned Physicians

The COVID-19 pandemic has reached a point where containment is no longer possible. The COVID-19 threat is real, and rapidly getting worse. Many of you are very nervous, some are unsure of the validity of the information you... read more

Moral Distress in the Health Professions

Moral Distress in the Health Professions

This is the first book on the market or within academia dedicated solely to moral distress among health professionals. It aims to bring conceptual clarity about moral distress and distinguish it from related concepts. Explicit... read more

Survivorship Will Be the Defining Challenge of Critical Care in the 21st Century

Survivorship Will Be the Defining Challenge of Critical Care in the 21st Century

Distracted by the high mortality rate of critical illness, we tend to overlook the essential fact that most patients survive the intensive care unit (ICU). Every year, millions of patients are discharged from the ICU... read more

Could Stress Ulcer Prophylaxis Increase Mortality in High-acuity Patients?

Could Stress Ulcer Prophylaxis Increase Mortality in High-acuity Patients?

Although considerable uncertainty remains, the inferences from SUP-ICU and PEPTIC are consistent with the hypothesis that proton pump inhibitors (PPIs) increase the risk of death in patients with higher illness severity.... read more

Which Component of Mechanical Power is Most Important in Causing VILI?

Repeated applications of tidal energy inflict lung damage (VILI) when stress and strain exceed the limits of tissue tolerance. Inflation work and energy are the products of pressure and volume, which are loosely associated... read more

Relative Hyperglycemia Predicts In-Hospital Mortality in Critically Ill Patients

Relative Hyperglycemia Predicts In-Hospital Mortality in Critically Ill Patients

Unlike absolute hyperglycemia, relative hyperglycemia, as assessed by the stress hyperglycemia ratio, independently predicts in-hospital mortality in critically ill patients across the glycemic spectrum. Future studies should... read more

Soluble Urokinase Receptor and AKI

Soluble Urokinase Receptor and AKI

The authors concluded that high suPAR levels were associated with Acute Kidney Injury (AKI) in various clinical and experimental contexts. This cohort study reports that suPAR was associated with subsequent AKI in several... read more

Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in ICUs

Effects of a Multimodal Program Including Simulation on Job Strain Among Nurses Working in ICUs

Among ICU nurses, an intervention that included education, role-play, and debriefing resulted in a lower prevalence of job strain at 6 months compared with nurses who did not undergo this program. Further research is... read more

PPIs vs. Histamine-2 Receptor Blockers for ICU Stress Ulcer Prophylaxis

PPIs vs. Histamine-2 Receptor Blockers for ICU Stress Ulcer Prophylaxis

ICU patients assigned to proton-pump inhibitors (PPIs) versus histamine-2 receptor blockers (H2RBs) for ulcer prophylaxis had marginally higher 90-day mortality that just missed statistical significance. Significantly fewer... read more

Effect of Stress Ulcer Prophylaxis on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

Effect of Stress Ulcer Prophylaxis on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation

Among ICU patients requiring mechanical ventilation, a strategy of stress ulcer prophylaxis with use of proton pump inhibitors vs histamine-2 receptor blockers resulted in hospital mortality rates of 18.3% vs 17.5%, respectively,... read more

Could the Furosemide Stress Test Clarify Resuscitative Goals?

Could the Furosemide Stress Test Clarify Resuscitative Goals?

Imagine that you admit a patient with septic shock. You resuscitate the patient as best you can with inopressors, fluids, and antibiotics. An adequate blood pressure is achieved. A reasonable amount of fluid is administered.... read more

If we don’t start looking after our doctors there will be no one to care for our patients

If we don’t start looking after our doctors there will be no one to care for our patients

"Would you choose medicine again?" I look into the eager faces of the sixth-formers I've been asked to speak to. Not for the first time, I hesitate before I answer. I love my job – it's a great privilege to be a Registrar... read more

Early Psychological Screening of ICU Survivors

Early Psychological Screening of ICU Survivors

Symptoms of post-traumatic stress, anxiety and depression assessed 1 week after ICU stay correlate with 3-month psychological outcome. The HADS and PTSS-10 may be useful aids to identify ICU survivors at high risk for... read more

Stress Management Intervention to Prevent PICS-Family in Patients’ Spouses

Stress Management Intervention to Prevent PICS-Family in Patients’ Spouses

Sensation Awareness Focused Training (SĀF-T) intervention during the ICU stay is feasible, acceptable, and may improve family caregivers' post-ICU outcomes. Larger clinical trial to assess the effectiveness of SĀF-T in... read more

Risks and Benefits of Stress Ulcer Prophylaxis for Patients With Severe Sepsis

Risks and Benefits of Stress Ulcer Prophylaxis for Patients With Severe Sepsis

Since the rate of gastrointestinal bleeding requiring endoscopic hemostasis is not different comparing patients with and without stress ulcer prophylaxis, and the increase in hospital-acquired pneumonia is significant, routine... read more

Climate Change, Global Warming, and Intensive Care

Climate Change, Global Warming, and Intensive Care

In the last five decades, human activities have resulted in the release of increasing quantities of carbon dioxide and other greenhouse gases, thus contributing to global climate change by additional heating of the atmosphere.... read more

Economic Evaluation of a Patient-Directed Music Intervention for ICU Patients Receiving Mechanical Ventilatory Support

Economic Evaluation of a Patient-Directed Music Intervention for ICU Patients Receiving Mechanical Ventilatory Support

Music intervention has been shown to reduce anxiety and sedative exposure among mechanically ventilated patients. The aim of this study was to examine ICU costs for patients receiving a patient-directed music intervention... read more