Risk Factors of Ischemic and Hemorrhagic Strokes During Venovenous ECMO

Risk Factors of Ischemic and Hemorrhagic Strokes During Venovenous ECMO

Among venovenous extracorporeal membrane oxygenation patients in the Extracorporeal Life Support Organization registry, approximately 5% had acute brain injury. Mortality rates increased two-fold when ischemic or hemorrhagic... read more

Endovascular Therapy for Acute Ischemic Stroke During COVID-19 Pandemic

Endovascular Therapy for Acute Ischemic Stroke During COVID-19 Pandemic

The evaluation and treatment of acute large vessel occlusion stroke present many challenges during the COVID-19 era. It may be difficult to screen stroke patients for COVID-19 symptoms because of encephalopathy or aphasia.... read more

Increase in Rare Brain Inflammation and Stroke Linked to COVID-19

Increase in Rare Brain Inflammation and Stroke Linked to COVID-19

Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus... read more

Blood Vessel Attack Could Trigger Coronavirus’ Fatal Second Phase

Blood Vessel Attack Could Trigger Coronavirus’ Fatal Second Phase

Frank Ruschitzka told his pathologist to be ready before the first COVID-19 patient died. In early March, Ruschitzka, who leads the cardiology department at University Hospital Zürich, noticed that patients with the disease... read more

Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort

Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort

In this cohort, the major risk factors for septicemia death were similar to those for other causes of death, there was approximately a 2-fold Black-White disparity in septicemia deaths, and the strongest mediators of this... read more

Fixing Hypernatremia: Acting Fast or Acting Slow?

Fixing Hypernatremia: Acting Fast or Acting Slow?

This is the largest adult cohort study focusing on the neurologic complications and mortality after hypernatremia correction in critically ill adults. There wasn't any evidence that rapid correction of hypernatremia was... read more

Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications

Hypothermia and Cerebral Ischemia: Mechanisms and Clinical Applications

A comprehensive review of the scientific and clinical studies that have led to the resurgence of interest in hypothermia as a neuroprotective strategy in the treatment of stroke and traumatic brain injury (TBI). Topics... read more

Intensive Care Unit Telemedicine, An Issue of Critical Care Clinics

Intensive Care Unit Telemedicine, An Issue of Critical Care Clinics

This issue of Critical Care Clinics, edited by Dr. Kianoush Kashani in collaboration with Consulting Editor Dr. John Kellum, is focused on Intensive Care Unit Telemedicine. Topics in this issue include: ICU telemedicine... read more

First Portable MRI Scanner for Neuro ICU

First Portable MRI Scanner for Neuro ICU

Health technology incubator Hyperfine Research and the Yale School of Medicine are testing out a first-of-its-kind, portable MRI scanner in the neuro intensive care unit (ICU). The point-of-care system, designed by Hyperfine,... read more

Parenteral Anticoagulation Not Associated with Reduced Risk of Ischemic Stroke Among Patients with Atrial Fibrillation During Sepsis

Parenteral Anticoagulation Not Associated with Reduced Risk of Ischemic Stroke Among Patients with Atrial Fibrillation During Sepsis

Among patients with Atrial Fibrillation (AF) during sepsis, parenteral anticoagulation was not associated with reduced risk of ischemic stroke and was associated with higher bleeding rates. Of 113,511 patients hospitalized... read more

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation

The CABANA Randomized Clinical Trial. In this randomized clinical trial involving 2204 patients with atrial fibrillation, catheter ablation, compared with medical therapy, did not significantly reduce the primary composite... read more

Early Prediction of Prognosis in Elderly Acute Stroke Patients

Early Prediction of Prognosis in Elderly Acute Stroke Patients

Acute stroke has a high morbidity and mortality in elderly population. Baseline confounding illnesses, initial clinical examination, and basic laboratory tests may impact prognostics. In this study, we aimed to establish... read more

Overuse of troponin? A comprehensive evaluation of testing in a large hospital system

Overuse of troponin? A comprehensive evaluation of testing in a large hospital system

Troponin assays are integral to the diagnosis of acute myocardial infarction (AMI), but there is concern that testing is over utilized and may not conform to published guidelines. We reviewed all testing performed at 14 hospitals... read more

Fluid Responsiveness in a Hemodynamically Unstable Patient

Fluid Responsiveness in a Hemodynamically Unstable Patient

Only half of patients who are hemodynamically unstable will respond to a fluid bolus. There are no historical or physical examination findings that can help us decide whether a patient is a fluid responder, but we must treat... read more

Dual Antiplatelet Therapy with Aspirin and Clopidogrel for Acute High Risk Transient Ischemic Attack and Minor Ischemic Stroke

Dual Antiplatelet Therapy with Aspirin and Clopidogrel for Acute High Risk Transient Ischemic Attack and Minor Ischemic Stroke

What is the role of dual antiplatelet therapy after high risk transient ischemic attack or minor stroke? Specifically, does dual antiplatelet therapy with a combination of aspirin and clopidogrel lead to a greater reduction... read more

Mortality and Morbidity in Acutely Ill Adults Treated with Liberal vs. Conservative Oxygen Therapy

Mortality and Morbidity in Acutely Ill Adults Treated with Liberal vs. Conservative Oxygen Therapy

In acutely ill adults, high-quality evidence shows that liberal oxygen therapy increases mortality without improving other patient-important outcomes. Supplemental oxygen might become unfavourable above an SpO2 range of 94-96%.... read more

Prevalence for Delirium in Stroke Patients

Prevalence for Delirium in Stroke Patients

These results underline the importance of delirium screening in stroke patients specifically during the night. Since even short delirious episodes are associated with more complications and increased disability, future studies... read more