Tag: study
Changes in Drug List Prices and Amounts Paid by Patients and Insurers
In this cross-sectional study, we found that increases in drug wholesale list prices are associated with increases in net patient out-of-pocket costs and insurer payments. This finding suggests that, although discounts and... read more
Risk factors and events in the adult ICU associated with pain as self-reported at the end of the intensive care unit stay
The short-term and long-term consequences of the most frequent painful procedures performed in the ICU are unclear. This study aimed to identify the risk factors associated with pain-related discomfort perceived by critically... read more
Apoptotic cells for therapeutic use in cytokine storm associated with sepsis
Sepsis has no proven specific pharmacologic treatment. Reported mortality in sepsis ranges from 30%-45%. This study was designed to determine the safety preliminary efficacy of allogenic apoptotic cells administered for immunomodulation... read more
Appendiceal Perforation at a Children’s Hospital During COVID-19 vs 2019
Although studies in the adult literature and case series in the pediatric literature have reported delays in medical care attributable to COVID-19, we report a statistically significant increased rate of appendiceal perforation... read more
Overlooked bias with thermometer evaluations using quickly retaken temperatures in EHR
Studies related to COVID-19 increasingly use electronic health records (EHR) to obtain large-scale evidence. However, EHR-based research must be performed with care because it can involve new study design problems that are... read more
14-Day Occurrence of Hypoxia, ICU Admission, and Death Among Patients with COVID-19
Uncertainty surrounding COVID-19 regarding rapid progression to acute respiratory distress syndrome (ARDS) and unusual clinical characteristics make discharge from a monitored setting challenging. Model derivation and... read more
Expert Consensus on Methodology for Conducting and Reporting Echocardiography Research Studies
Echocardiography is a common tool for cardiac and hemodynamic assessments in critical care research. However, interpretation (and applications) of results and between-study comparisons are often difficult due to the lack... read more
Predictors of QT Interval Prolongation in Critically-ill Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine
Hydroxychloroquine (HCQ) has been described as a potential treatment for SARS-CoV-2 infection. However, there are safety concerns regarding its QT interval and pro-arrhythmic effects. This trial aimed to determine the... read more
Assessment of Cancer Therapy Evaluation Program Advocacy and Inclusion of People With HIV in Anti–PD1/PDL1 Trials
This study identified encouraging trends in the inclusion of PLWH in anti–PD1/PDL1 cancer trials that occurred in the period following the initiation of CTEP advocacy. Work is needed to examine what impact this will have... read more
Electronic Nicotine Delivery System Use and Cigarette Smoking Among Young Adults
This cohort study uses propensity score matching analyses of 3 years of data from the Population Assessment of Tobacco and Health Study to assess whether there is an association between electronic nicotine delivery system... read more
Antibody levels decline after 2 months, CDC finds
COVID-19 antibody levels declined within two months in 156 front-line healthcare workers involved in a CDC study published Nov. 27. Researchers collected blood samples from 3,248 front-line healthcare professionals between... read more
The Impacts of Gender Disparity in Residency Matching
A critical turning point for the female physician is highlighted in the study by Lorello et al1 as another one of the numerous inequities throughout the female physician’s career life cycle. Their study’s extensive assessment... read more
Management of Children With Fever at Risk for Pediatric Sepsis
Many febrile children (41%) present with warning signs for sepsis, with only few of them undergoing investigations or treatment for true sepsis. Children with positive isolates in blood or CSF culture presented in a heterogeneous... read more
Utility of RV Remodeling Over Risk Stratification in COVID-19
This study contributes to the growing body of literature illustrating the adverse prognostic implications of RV dilation and dysfunction in the setting of severe COVID-19. Mechanistic explanations for RV failure in this population... read more
Will COVID-19 Vaccines Save Lives? Current Trials Aren’t Designed To Tell Us
The world has bet the farm on vaccines as the solution to the pandemic, but the trials are not focused on answering the questions many might assume they are. As phase III trials of covid-19 vaccines reach their target... read more
Resilience in a Prehospital Setting – A New Focus for Future Research?
Empirical research is of crucial importance to understand, build and support resilient systems and processes, including exploring and developing interventions to improve capacity for adaptive change in a prehospital setting. Handling... read more
The Use of Venous Doppler to Predict Adverse Kidney Events in a General ICU Cohort
This study indicates that portal and hepatic flows may be clinical useful tools to help identify patients at risk for renal injury. It is likely that they are indicative of elevated right atrial pressure causing venous congestion,... read more
Implantation of Impella CP Left Ventricular Assist Device Under the Guidance of 3D Intracardiac Echocardiography
Three-dimensional intracardiac echocardiography is a feasible option to guide implantation of the Impella CP for left ventricular mechanical support and should be carefully considered in cases where other imaging modalities... read more
