Tag: study
Decreased Intestinal Microbiome Diversity in Pediatric Sepsis
Intestinal dysbiosis was associated with altered short-chain fatty acid metabolites in children with sepsis, but these findings were not linked directly to mitochondrial or immunologic changes. More detailed mechanistic studies... read more
Vaccine-Induced Prothrombotic Immune Thrombocytopenia After AstraZeneca COVID-19 Vaccination
The United Kingdom, European Union, and Scandinavian countries have reported that the AstraZeneca COVID-19 vaccine appears to be associated with rare cases of serious blood clots, including blood clots in the brain. These... read more
Early Tracheotomy Shortens ICU Stay and Lowers Risk of VAP
Compared with late tracheotomy, early intervention was associated with lower ventilator-associated pneumonia (VAP) rates and shorter durations of mechanical ventilation and ICU stay, but not with reduced short-term, all-cause... read more
SARS-CoV Replication-transcription Complex Can Initiate RNA Synthesis
How viruses from the Coronaviridae family initiate viral RNA synthesis is unknown. Here we show that the SARS-CoV-1 and −2 Nidovirus RdRp-Associated Nucleotidyltransferase (NiRAN) domain on nsp12 uridylates the viral cofactor... read more
COVID-19 Infects Mouth Cells
Scientists have shown that SARS-CoV-2, the virus that causes COVID-19, can infect specific cells in the salivary gland in the mouth. The study by researchers from the Wellcome Sanger Institute, National Institutes of Health... read more
Correlation Between COVID-19 Mortality and Autoantibodies in Patients Treated with Corticosteroids
Auto-reactivity in COVID-19 is increasingly being recognized and may identify a group of patients with inflammation severe enough to result in loss of self-tolerance. Corticosteroids are potent anti-inflammatory agents and... read more
Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients
In this observational study of intubation practices in critically ill patients from a convenience sample of 197 sites across 29 countries, major adverse peri-intubation events—in particular cardiovascular instability—were... read more
International Variation in Intubation and Extubation Practices Among Critically Ill Patients Receiving Mechanical Ventilation
Requiring invasive mechanical ventilation acutely outside an operating room is, for many, the definition of critical illness. Although there may be debate regarding whether patients treated with noninvasive ventilation or... read more
Can Ultrasound Predict Histologic Pattern of Lung Injury in COVID‑19 patient?
We have read with great interest the study by de Almeida Monteiro et al. recently published in Intensive Care Medicine, where authors studied the relationship between histopathological data and lung ultrasonographic (LUS)... read more
Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU
In our small, single-center study, patients treated with haloperidol or quetiapine showed no short-term improvement in delirium screening scores after starting treatment when compared with untreated, propensity score-matched... read more
An overview of the current AstraZeneca vaccine situation in Europe
On Thursday, March 11, 2021, Denmark suspended the use of the AstraZeneca vaccine (developed in collaboration with the University of Oxford) completely. Some other European countries followed suit. This prompted an investigation... read more
Galectin-3 in Septic AKI
This translational study demonstrates the importance of Gal-3 in the pathogenesis of sepsis acute kidney injury (S-AKI), and its potential utility as a therapeutic target. In 57 patients admitted to the intensive care... read more
Increased risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1
We started estimating the SARS-CoV-2 reproduction number in the UK using Public Health England data in March 2020, contributing to the Scientific Pandemic Influenza Modelling subgroup (SPI-M) weekly consensus estimates. In... read more
The Influence of Airflow Via High-Flow Nasal Cannula on Duration of Laryngeal Vestibule Closure
The purpose of this experimental study was to investigate the influence of airflow via high-flow nasal cannula (HFNC) on the duration of laryngeal vestibule closure (dLVC) and Penetration-Aspiration Scale (PAS) scores. 29... read more
Outcomes and Risk Factors Associated with COVID-19 Infection of Patients with Multiple Sclerosis
In this registry-based cross-sectional study, increased disability was independently associated with worse clinical severity including death from COVID-19. Other risk factors for worse outcomes included older age, Black race,... read more
Effect of Intermediate-Dose vs. Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, ECMO Treatment, or Mortality Among Patients With COVID-19 in ICU
Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome... read more
Cardiorespiratory Compromise in the Perioperative Environment
Perioperative cardiorespiratory compromise is common and goes largely undetected. Predictive cardiorespiratory indices can help in early detection of harmful deviations and guide preemptive treatment. Using continuous... read more
A Systematic Review of Indoor Air Sampling for COVID-19 Detection
In a post-pandemic scenario, indoor air monitoring may be required seeking to safeguard public health, and therefore well-defined methods, protocols, and equipment play an important role. Considering the COVID-19 pandemic,... read more
Long-Term Survival Following Sepsis
The nearly 75% mortality four years after diagnosis indicates that changes are needed both in the acute treatment of patients with sepsis and in their multi-sector long-term care. The applicability of these findings may be... read more
Monitoring tissue oxygenation index using near‐infrared spectroscopy during pre‐hospital resuscitation
In this pilot study, we demonstrated the feasibility of ∆TOI as a dynamic value rather than single static value among OHCA patients in a pre-hospital setting. ∆TOI can be considered as a predictor of return of spontaneous... read more
Intraosseous vs. Intravenous Vascular Access During CPR for Out-of-hospital Cardiac Arrest
The meta-analysis revealed no significant association between types of vascular access and neurological outcomes at hospital discharge among out-of-hospital Cardiac Arrest (OHCA) patients. Time to intervention was identified... read more
Left Ventricular Assist Device Implantation in Hypertrophic and Restrictive Cardiomyopathy
Left ventricular assist device (LVAD) implantation in patients with advanced heart failure due to hypertrophic or restrictive cardiomyopathy (HCM/RCM) presents technical and physiologic challenges. We conducted a systematic... read more
