Tag: therapy
Efficacy of Combination Therapy of Shenfu Injection and Postresuscitation Bundle in Patients With Return of Spontaneous Circulation
This study demonstrates that Shenfu injection in combination with conventional postresuscitation care bundle treatment is effective at improving clinical outcomes in patients with return of spontaneous circulation after in-hospital... read more
Principles of Antimicrobial Stewardship for Bacterial and Fungal Infections in ICU
Selecting antimicrobial therapy for suspected infection in critically ill patients is an important decision-making process for intensivists. In this current age of multi-drug-resistant organisms (MDROs), intensivists must... read more
FDA Approves ‘living drug’ to Cure Cancer
FDA has approved the first treatment to redesign immune system so it attacks the cancer cells. Kymriah therapy, which leaves 83% of people free of a type of blood cancer, costs about $475,000 and was developed by Novartis.... read more
Oxygen Therapy in Suspected Acute Myocardial Infarction
Routine use of supplemental oxygen in patients with suspected myocardial infarction who did not have hypoxemia was not found to reduce 1-year all-cause mortality. A total of 6629 patients were enrolled. The median duration... read more
Current Clinical Nutrition Practices in Critically Ill Patients in Latin America
In the ICU setting in Latin America, malnutrition was highly prevalent and caloric intake failed to meet targeted energy delivery in 40% of critically ill adults receiving nutrition therapy. Supplemental administration of... read more
Successful Long-Term ECMO for Invasive Pulmonary Aspergillosis
Extracorporeal membrane oxygenation is an established life-saving procedure for severe acute respiratory failure due to various causes. Long-term extracorporeal membrane oxygenation might be considered if the primary causes... read more
Whole Body Hyperthermia Appeared to Reduce Depression Symptoms
Whole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Results from the current study suggest that WBH holds promise as a safe, rapid-acting, antidepressant... read more
Muscle Oxygenation as Indicator of Shock Severity
The aim of this pilot study was to evaluate the potential of a new noninvasive optical measurement of muscle oxygenation (MOx) to identify shock severity in patients with suspected sepsis. We demonstrate that noninvasive... read more
Anabolic and Anticatabolic Agents in Critical Care
Profound metabolic derangements occur in critically ill patients; this hypermetabolic response is a major contributor to adverse outcomes. Despite the pharmacological therapies currently available to counteract this devastating... read more
The Science and Art of Pediatric Critical Care Nutrition
Malnutrition is prevalent in the pediatric ICU population, and is associated with worse outcomes. Nutrition support teams, dedicated dietitians, and educational programs facilitate surveillance for existing malnutrition and... read more
Direct Oral Anticoagulant- or Warfarin-Related Major Bleeding
Direct oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin... read more
The Intensive Care Medicine Research Agenda on Critically Ill Oncology and Hematology Patients
Over the coming years, accelerating progress against cancer will be associated with an increased number of patients who require life‑sustaining therapies for infectious or toxic chemotherapy‑related events. Major changes... read more
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient
This document represents the first collaboration between two organizations, American Society of Parenteral and Enteral Nutrition and the Society of Critical Care Medicine, to describe best practices in nutrition therapy in... read more
Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration
Among comatose patients receiving mechanical ventilation, those without clinical, laboratory, or radiologic evidence of bacterial aspiration pneumonia did not require antibiotics. In those with suspected bacterial aspiration... read more
The Role of Oliguria and the Absence of Fluid Administration and Balance Information in Illness Severity Scores
Urinary examination has formed part of patient assessment since the earliest days of medicine. Current definitions of oliguria are essentially arbitrary, but duration and intensity of oliguria have been associated with an... read more
The Complexities of Intravenous Fluid Research: Questions of Scale, Volume, and Accumulation
Despite near ubiquity, information regarding fluids consumption at a health care systems level, and patient exposure at an individual level, is surprisingly limited in the medical literature. The epidemiology of the foundational... read more
Aspirin therapy in patients with ARDS is associated with reduced ICU mortality
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome with high mortality and long-term morbidity. To date there is no effective pharmacological therapy. Aspirin therapy has recently been shown to reduce... read more
New Biomarker Improves Early Sepsis Detection in the Emergency Department
Sepsis most often presents to the emergency department (ED), and delayed detection is harmful. The white blood count (WBC) is often used to detect sepsis in the ED. New research shows that volume increases of circulating... read more
Evaluation of early antimicrobial therapy adaptation guided by the BetaLACTA test
Rapid diagnostic tests detecting microbial resistance are needed for limiting the duration of inappropriateness of empirical antimicrobial therapy (EAT) in ICU patients, besides reducing the use of broad-spectrum antibiotics.... read more
A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses
Uncomplicated skin abscesses are common, yet the appropriate management of the condition in the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA) is unclear. As compared with incision and drainage... read more
An NIH-Kennedy Center Initiative to Explore Music and the Mind
Music is fundamental to the human species in ways that reach beyond entertainment or pastime. In Musicophilia, Oliver Sacks noted that music can "calm us, animate us, comfort us, thrill us, or serve to organize and synchronize... read more
Angiotensin II may improve vasopressors’ efficacy
Adding angiotensin II to available vasopressor therapies correlated with significantly improved arterial pressure in patients with catecholamine-resistant vasodilatory shock and less adverse effects, according to a study... read more
