Tag: therapy
Potential Therapy for Improving Sudden Cardiac Arrest Resuscitation Outcomes
The severity of cardiogenic shock following asystolic cardiac arrest is dependent on the length of cardiac arrest prior to cardiopulmonary resuscitation and is mediated by myocardial stunning resulting from mitochondrial... read more
Correction and Control of Hyperammonemia in Acute Liver Failure
Continuous renal replacement therapy (CRRT) is associated with reduced ammonia concentrations in acute liver failure patients. This effect is related to greater cumulative dose. These findings suggest that continuous... read more
Beta-Blocker Therapy in Severe TBI
Propranolol decreases in-hospital mortality and improves long-term functional outcome in isolated severe Traumatic Brain Injury (TBI). This randomized trial speaks in favor of routine administration of beta-blocker therapy... read more
Comprehensive Review of Infectious Diseases
Perfect for board review or quick reference in clinical practice, Comprehensive Review of Infectious Diseases is a balanced, high-yield resource covering the full range of infectious disease topics. Whether you're preparing... read more
PPIs vs. Histamine-2 Receptor Blockers for ICU Stress Ulcer Prophylaxis
ICU patients assigned to proton-pump inhibitors (PPIs) versus histamine-2 receptor blockers (H2RBs) for ulcer prophylaxis had marginally higher 90-day mortality that just missed statistical significance. Significantly fewer... read more
Intravenous Fluid Therapy in Critically Ill Adults
Despite the administration of intravenous fluids to critically ill patients being a near-universal intervention, the available evidence base guiding their safe and appropriate use is scarce and derived mainly from academically... read more
Sepsis: Staging and Potential Future Therapies
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical... read more
Pulse oximeter as a sensor of fluid responsiveness: do we have our finger on the best solution?
Additional studies – including volume challenge – are mandatory if we are to determine whether respiratory variation in pulse oximetry really can predict volume responsiveness in mechanically ventilated patients without... read more
Practical Transfusion Medicine
The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert hematologists,... read more
Incidence of Dexmedetomidine Withdrawal in Adult Critically Ill Patients
The majority of patients in our study demonstrated signs that may be indicative of dexmedetomidine withdrawal. Peak and cumulative daily dexmedetomidine dose, rather than duration of therapy, may be associated with a higher... read more
Initial Therapy Affects Duration of Diarrhoea in Critically Ill Patients with Clostridioides Difficile Infection
Clostridioides Difficile Infection (CDI) further harms critically ill patients by increasing 28-day mortality and in case of prolonged diarrhoea the length of their hospital stay. Appropriate therapy should be initiated... read more
The Oxygen Revolution: The Definitive Treatment of Traumatic Brain Injury (TBI) & Other Disorders
Hyperbaric oxygen therapy (HBOT) is based on a simple idea—that oxygen can be used therapeutically for a wide range of conditions where tissues have been damaged by oxygen deprivation. Inspiring and informative, The... read more
Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions
Centralized pain syndromes are associated with changes within the central nervous system that amplify peripheral input and/or generate the perception of pain in the absence of a noxious stimulus. Examples of idiopathic... read more
Corticosteroids as Adjunctive Therapy in the Treatment of Influenza
Corticosteroid treatment in influenza is associated with increased mortality and hospital-acquired infection, but the evidence relates mainly to high corticosteroid doses and is of low quality with potential confounding by... read more
