Tag: treatment
Rethinking Blood Pressure Goals: Why High vs. Low MAP Targets Affect Patients with Septic Shock
Based on a study of 776 patients, there's no evidence that different groups of people with septic shock respond differently to a high versus low mean arterial pressure (MAP) target. In other words, there wasn't a "one-size-fits-all"... read more
Predicting Mortality in Sepsis-Related ARDS Using Machine Learning
The application of machine learning methodologies to construct prognostic prediction models for sepsis patients complicated by ARDS, informed by the new global definition, proves to be reliable. This approach can assist clinicians... read more
Long-Term Trends of Penicillin-Nonsusceptible Group B Streptococcus: A 24-Year Retrospective Study
A 24-year study at a single hospital shows a troubling trend: a significant increase in both Group B Streptococcus (GBS) infections and strains resistant to penicillin (PCN-NS GBS). This highlights a growing problem with... read more
Managing a Critically Ill Patient with HIV, TB, and COVID-19
Treating a patient with HIV, active tuberculosis (TB), and COVID-19 is an immense clinical challenge due to the complex interplay of these three infections. This rare but dangerous combination significantly increases the... read more
Intravenous High-Dose Magnesium for New-Onset Rapid Atrial Fibrillation in the ICU
New-onset atrial fibrillation (AF) is a frequent complication in the intensive care unit (ICU) and is associated with poorer patient outcomes. Despite international guidelines offering limited recommendations, a growing body... read more
Critical Care Ultrasonography Usage in the Management of Cardiogenic Shock
Despite advancements in treatment, cardiogenic shock (CS) still has a very high mortality rate. To improve patient outcomes, a timely diagnosis and the correct management are crucial. This is especially true given the changing... read more
oXiris Treatment Efficacy To Reduce Endotoxin Levels
In this pilot study of patients with CS requiring VA-ECMO, the application of an oXiris did not demonstrate a significant reduction in endotoxin levels at 48 h compared with standard care. While we observed temporal decreases... read more
Severe Listeriosis in the ICU: Critical Insights from a Multicenter Study
A retrospective multicenter study across 23 French hospitals over 10 years analyzed critically ill ICU patients with culture-confirmed "Listeria monocytogenes" infections. The study aimed to describe patient characteristics,... read more
Sepsis and Septic Shock: An Issue of Critical Care Clinics
Shock is caused by the decreased flow of blood to the body tissues due to circulatory system related problems. Sepsis refers to a life-threatening condition where the body causes injury to its own organs and tissues in response... read more
Hemodynamic Stabilization Using CRRT and cIVNa Combination Therapy
Compared with conventional continuous renal replacement therapy (CRRT), combination therapy of CRRT and continuous intravenous sodium infusion therapy (cIVNa) increased blood pressure, enhanced urinary volume, and reduced... read more
A Novel Mechanism for COVID-19 Related Thrombotic Events: Platelet NO/ROS Equilibrium
The finding that platelet NO/ROS production imbalance contributes to the elevated risk of thrombotic events in COVID-19 has important clinical implications. Restoration of platelet NO production, as well as attenuation... read more
Red Book: Report of the Committee on Infectious Diseases
Extending an 8-decade tradition of excellence, Red Book® provides the most reliable and clinically useful information on the manifestations, etiology, epidemiology, diagnosis and treatment of more than 200 childhood infectious... read more
COVID-19 Handbook: Navigating the Future of Healthcare
The COVID-19 Handbook: Navigating the Future of Healthcare provides factual, evidence-based information on the coronavirus disease 2019 (COVID-19) pandemic. Presented in a concise PDF format, this valuable COVID-19 resource... read more
Tocilizumab vs. IVIG in Patients with Severe COVID-19 Pneumonia
Severe COVID-19 patients who received IVIG in the early phase of the disease did not show better clinical outcomes in terms of mortality, hospitalization time and intensive care unit admission compared to those who received... read more
Femoral Head Osteonecrosis in Post-COVID-19 Patients
This study provides an insight into the relationship between COVID-19-related factors and the development of osteonecrosis of the femoral head (ONFH), emphasizing the critical role of cumulative steroid dose as the primary... read more
Baricitinib Use in Children with Severe COVID-19 Infection
Baricitinib appears safe for both immunocompetent and immunocompromised children hospitalized for severe COVID-19. Most adverse events did not inhibit therapy administration, and there were no deaths following the initiation... read more
Dynamic Left Ventricular Outflow Tract Obstruction Induced by IABP in Patient with Angioedema
Mechanical circulatory support with intra-aortic balloon pump (IABP) can aid in the treatment of cardiogenic shock but may rapidly become detrimental due to the reduction in systolic arterial afterload in patients with predispositions... read more
Septic Shock Metabolic Subgroups and Clinical Outcome
Three metabolic clusters exist in patients with septic shock with most metabolites differing between clusters and lipid species being most influential. Cluster proportions evolved over time with a high metabolite group... read more
Sepsis: Staging and Potential Future Therapies
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical... read more
VA-ECMO and Pulmonary Reperfusion
The study by Stadlbauer and colleagues provides further evidence that veno-arterial extracorporeal membrane oxygenation (VA-ECMO) should—whenever necessary—be used, as a bridge to pulmonary reperfusion, but not as a bridge... read more
Successful Clearance of Persistent Staphylococcus Aureus Pneumonia Using High-dose Continuous Infusion Cefazolin
High-dose cefazolin (10 g daily), given as a continuous infusion (CI), was able to clear community-acquired methicillin-susceptible Staphylococcus aureus (MSSA) pneumonia while not exhibiting any signs of toxicity or adverse... read more
Pulmonary Hypertension: Basic Science to Clinical Medicine
This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles... read more
