Tag: treatment
Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation
Among patients with unhealthy alcohol use receiving mechanical ventilation, treatment with high-dose baclofen, compared with placebo, resulted in a statistically significant reduction in agitation-related events. The primary... read more
Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of SSc-PAH
B cell depletion therapy is a potentially effective and safe adjuvant treatment for systemic sclerosis-pulmonary arterial hypertension (SSc-PAH). Future studies in these patients can confirm whether the identified biomarkers... read more
Chloroquine/Hydroxychloroquine for Treating or Preventing COVID-19 Infection
When given along with azithromycin, hydroxychloroquine increased the risk of any unwanted effects, but made no difference to the risk of serious unwanted effects (1 study; 444 people). Compared with lopinavir plus ritonavir,... read more
Antiviral Drugs in Hospitalised COVID-19 Patients
These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital... read more
Functional outcome after inpatient rehabilitation in post-intensive care unit COVID-19 patients
These findings suggest that post-acute COVID-19 patients might beneficiate of a motor and respiratory rehabilitation treatment. However, further studies are advised to better understand long-term sequelae of the disease. Medical... read more
Interleukin-6 Receptor Antagonists in Critically Ill Patients with COVID-19
In critically ill patients with COVID-19 receiving organ support in ICUs, treatment with the interleukin-6 receptor antagonists tocilizumab and sarilumab improved outcomes, including survival. Both tocilizumab and sarilumab... read more
Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19
Treatment with convalescent plasma compared with placebo or standard of care was not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence... read more
Effect of a Single High Dose of Vitamin D3 on Hospital LOS in Patients with COVID-19
Among hospitalized patients with COVID-19, a single high dose of vitamin D3, compared with placebo, did not significantly reduce hospital length of stay. The findings do not support the use of a high dose of vitamin D3 for... read more
Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation
This study suggests that early intervention for patients with postintubation laryngeal injury was associated with a decreased duration of tracheostomy dependence, a higher rate of decannulation, and fewer surgical procedures... read more
RECOVERY trial shows tocilizumab reduces deaths in patients hospitalised with COVID-19
The NIHR-supported RECOVERY trial has shown that tocilizumab - an anti-inflammatory rheumatoid arthritis treatment - reduces the risk of death for hospitalised patients with severe COVID-19. Researchers also found that... read more
Surviving Sepsis Campaign Guidelines on the Management of Adults with COVID-19 in the ICU
The Surviving Sepsis Campaign Coronavirus Disease 2019 panel issued several recommendations to guide healthcare professionals caring for adults with critical or severe coronavirus disease 2019 in the ICU. Based on a living... read more
FDA Limits Use of Convalescent Plasma as COVID-19 Treatment
The Food and Drug Administration (FDA) is scaling back its authorization of the use of convalescent blood-plasma for COVID-19 patients in an effort to guide physicians who have faced a confusing thicket of data about the... read more
Mortality of Older Patients Admitted to an ICU
In this systematic review of older patients admitted to intensive care, we have documented substantial variation in short- and long-term mortality as well as in prognostic factors evaluated. To better understand this... read more
Allergic Reactions After First Dose of Pfizer-BioNTech COVID-19 Vaccine
Anaphylactic reactions to the first dose of the Pfizer-BioNTech COVID-19 vaccine are rare, usually occur within 30 minutes of administration, and are readily treatable. From December 14-23, 2020, following administration... read more
High-dose Vitamin C in Critically Ill COVID-19 Patients
This pilot trial showed that high-dose intravenous vitamin C (HDIVC) failed to improve IMVFD28, but might show a potential signal of benefit in oxygenation for critically ill patients with COVID-19 improving PaO2/FiO2 even... read more
