Leveraging the Power of Routinely Collected ICU Data

With the steady advent of electronic health records, the abundance of routinely recorded data related to the treatment and care of intensive care unit (ICU) patients can be nothing short of overwhelming. Over tens of... read more

Emergence of Ventilator Associated Pneumonia in Critical Care Units

In intensive care unit, the care of critically ill patients is a primary component of modern medicine. Intensive care units create potential for recovery in patients who otherwise may not have survived. They are, however,... read more

Emergence of Ventilator Associated Pneumonia in Critical Care Units

ECMO. Extracorporeal Membrane Oxygenation

Extracorporeal membrane oxygenation (ECMO), is a rapidly developing technology for supporting or even replacing heart and/or lung functions for days or weeks, giving the time for recovery, other therapeutic interventions... read more

ECMO. Extracorporeal Membrane Oxygenation

Establishment and Validation of a Risk Prediction Model for Sepsis-Associated Liver Injury in ICU Patients

This novel nomogram effectively predicts SALI risk in sepsis patients by integrating readily available clinical parameters. While external validation is needed, the model shows promise as a practical tool for early risk stratification,... read more

Sepsis Management: PIRO and MODS

This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent... read more

Sepsis Management: PIRO and MODS

Sepsis: Methods and Protocols

This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical... read more

Sepsis: Methods and Protocols

Procalcitonin Correlation with SEPSIS Severity in ICU Patients

High rates of morbidity and death are linked to sepsis, a potentially fatal illness. Procalcitonin (PCT), a biomarker of bacterial infection, is increasingly used in sepsis management to evaluate disease severity and guide... read more

Successful Treatment of Unilateral Pulmonary Edema as Minimally Invasive Mitral Valve Surgery Complication

We successfully treated this patient using ECMO and independent lung ventilation. Several cases have been described in the literature, but the pathogenesis and risk factors of UPE remain unclear. Management depends on... read more

Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their... read more

Biomarkers in Trauma, Injury and Critical Care (Biomarkers in Disease: Methods, Discoveries and Applications)

Pulmonary Hypertension: Basic Science to Clinical Medicine

This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles... read more

Pulmonary Hypertension: Basic Science to Clinical Medicine

Effect on Norepinephrine Administration Timing on Prognosis of Septic Shock Patients

Norepinephrine initiation ≤1 h is associated with lower 28-day mortality in patients with septic shock. Early norepinephrine administration is also associated with a shorter time to achieve MAP ≥65 mmHg, lower 24-h intravenous... read more

Sepsis: Clinical Diagnosis and Treatment

Sometimes our body's reaction to infection can result in damage to internal tissues and organs. Such a condition is referred to as sepsis. Some of the symptoms of sepsis are high fever, increased heart and breathing rate,... read more

Sepsis: Clinical Diagnosis and Treatment

An Optimal Antibiotic Selection Framework for Sepsis Patients Using AI

In this work we present OptAB, the first completely data-driven online-updateable antibiotic selection model based on Artificial Intelligence (AI) for Sepsis patients accounting for side-effects. OptAB performs an iterative... read more

Personalized Therapies in ARDS

Acute respiratory distress syndrome (ARDS) can result from a variety of clinical conditions, causing lung injury either directly through local inflammation or indirectly because of systemic inflammatory mediators ARDS is... read more

Metabolic Disorders and Critically Ill Patients: From Pathophysiology to Treatment

Cellular metabolic abnormalities are responsible for systems and organ failures, so the modern approach of organ dysfunctions now includes prevention or treatment of such disorders. This book is a comprehensive tool, allowing... read more

Metabolic Disorders and Critically Ill Patients: From Pathophysiology to Treatment

AI Interpretation of Chest Radiographs in the ICU. Ready for Prime Time?

Chest radiography (CXR) is the primary tool to visualize thoracic pathologies in the ICU. However, accurate interpretation of CXRs is challenging, even when imaging is performed under optimal conditions. This results... read more

Rethinking Energy and Protein Provision for Critically Ill Patients

In critically ill patients, we suggest that energy and protein be delivered progressively in stable or recovering patients. If a patient deteriorates, regardless of days spent in the ICU, low-dose energy and protein should... read more

Antibiotic prophylaxis reduced broad-spectrum antibiotics and length of stay in ICU patients with alcohol withdrawal induced refractory delirium tremens

Administration of TMP-SMX prophylaxis reduced the use of broad-spectrum antibiotics and ICU LOS in ICU-treated rDT patients. The retrospective study design should be considered when interpreting the results, and prospective... read more

Researchers to Study Online Therapy’s Potential to Prevent Cognitive Decline in ICU Survivors

Researchers from Indiana University Indianapolis, Regenstrief Institute and the IU School of Medicine’s Indiana Alzheimer’s Disease Research Center – led by Babar Khan, M.D., M.S., Sophia Wang, M.D., and Jesse Stewart,... read more

COVID-19 and the Cardiovascular System: From Pathophysiology to Clinical Management

COVID-19 and the Cardiovascular System: From Pathophysiology to Clinical Management comprehensively covers COVID-19's impact on the cardiovascular system. Coverage includes the pathophysiology, clinical manifestations, diagnostic... read more

COVID-19 and the Cardiovascular System: From Pathophysiology to Clinical Management

COVID-19 Pneumonia: Different Respiratory Treatments for Different Phenotypes?

Type L and Type H patients are best identified by CT scan and are affected by different pathophysiological mechanisms. If not available, signs which are implicit in Type L and Type H definition could be used as surrogates:... read more

Predictive Value of Combined Detection of Serum LGALS3BP and GDF-15 for the Prognosis of ICU Sepsis Patients

Serum LGALS3BP and GDF-15 levels are abnormally elevated in the death group of ICU sepsis patients, suggesting potential application value as prognostic markers for sepsis. The combined use of LGALS3BP and GDF-15 can... read more