Tag: treatment
Prominent clinical guidelines fall short of conflict of interest standards
Two recent clinical practice guidelines, one for cholesterol management and another for treatment of chronic hepatitis C, did not meet the Institute of Medicine's standards for limiting commercial conflicts of interest, according... read more
Acetaminophen, Among Other Medications, Triggers Drug-Induced Liver Injury
More than 1,000 medications, with acetaminophen being the most common, have been associated with drug-induced liver injury (DILI). Diagnosis can be challenging due to the multitude of contributing factors, and timely recognition... read more
Spinraza Cuts Risk of Permanent Ventilation with SMA
Biogen announced new data from the Phase 3 ENDEAR study that showed a statistically significant reduction in the risk of death or permanent ventilation in Spinraza (nusinersen)-treated infants with spinal muscular atrophy... read more
Cholera bacteria infect more effectively with a simple twist of shape
The bacteria that cause the life-threatening disease cholera may initiate infection by coordinating a wave of mass shapeshifting that allows them to more effectively penetrate the intestines of their unwitting victims, according... read more
Attenuated T-cell Vaccination Helps SLE Patients
Vaccinating systemic lupus erythematosus (SLE) patients with attenuated T-cells improved their symptoms, according to results of a small controlled trial. T-cells are immune cells that play a key role in lupus.... read more
ACC Releases Afib Treatment Interruption Guidelines
Revised recommendations released today by the American College of Cardiology are designed to help clinicians determine if, and for how long, Afib patients on anticoagulants should be taken off the medications before scheduled... read more
Sepsis Algorithm a Deadly Marker
An attempt by a Phoenix, AZ, hospital to develop a marker for deadly sepsis instead found that the algorithm identified patients at an increased risk of dying. Increasingly, algorithms govern daily life, playing an important... read more
Poor outcome predictors in status epilepticus
Predictors of poor outcomes in patients with status epilepticus admitted to the neurointensive care unit include complex partial status epilepticus, refractory status epilepticus, or the development of nonconvulsive status... read more
First ICU for Men Suffering from Cold
There's finally hope for the critically ill! The Münster University Hospital has set up an intensive care unit exclusively for the treatment of male patients suffering from coughs, colds, or even both. A specially trained... read more
Hospital ICUs Are Overused
A study conducted on ICU admissions at Harbor-UCLA Medical Center states that the hospital’s Intensive Care Units are being overused by non-deserving patients. This revelation is suggesting that the hospital’s most evasive... read more
In-Bed Cycling Feasible for ICU Patients on Ventilation
TryCYCLE was the first study in the CYCLE research program. In TryCYCLE, we determined it was safe and feasible to bike with mechanically ventilated medical surgical patients very early in their ICU stay.... read more
Metformin Associated with Reduced Mortality in CKD, CHF, and CLD
Metformin is currently the suggested initial treatment for type 2 diabetes mellitus in the United States. In the past, the U.S. Food and Drug Administration (FDA) did not recommend metformin for patients with chronic kidney... read more
PERTs Aim to Disentangle Gordian Knot of Acute Pulmonary Embolism
The concept of a rapid response team for acute PE has spread quickly across the United States, although the impact remains unclear. A recently published research letter in CHEST showed that the most common specialties involved... read more
Patient Achieves Remission With CAR-T Cell Therapy for Aggressive Brain Tumors
A case study published in the December 29 issue of the New England Journal of Medicine outlines the results of a patient treated with his own genetically modified CAR-T cells, using central memory T cells, a stem-cell-like... read more
Triple therapy for influenza with naproxen, clarithromycin, and oseltamavir?
Antiviral therapy for influenza is a sore subject. Oseltamavir was initially felt to be a silver bullet. Unfortunately, it turned out that its efficacy was overblown by publication bias. Discordance between guidelines, practice,... read more
Meta-Analysis of Therapeutic Hypothermia for Traumatic Brain Injury
Therapeutic hypothermia is likely a beneficial treatment following traumatic brain injuries in adults but cannot be recommended in children.... read more
Seizures Prior to Diagnosis of Tuberous Sclerosis Complex
Seizures were a condition commonly experienced by patients prior to diagnosis of TSC; understanding the initial diagnoses experienced by TSC patients may help lead to earlier diagnosis and treatment of TSC. Many patients... read more
Disease Causation Index Established By New Mathematical Model
Patients with complex diseases have a higher risk of developing another. Multi-morbidity represents a huge problem in everyday clinical practice, because it makes it more difficult to provide successful treatment. By analysing... read more
Epstein-Barr risk increased by Immune Molecule Deficiency
Researchers from the National Institutes of Health National Institute of Allergy and Infectious Diseases, or NIAID, have found a genetic immune disorder causing increased risk and poor control of Epstein-Barr virus and EBV-associated... read more
Clinical challenge in IBD expanded by Systemic inflammation
More targeted antibody therapies carry the potential to transform how physicians treat inflammatory bowel disease. However, management can become less clear when IBD patients present with extra-intestinal manifestations.... read more
Think Sepsis and Act Fast
New attention to sepsis including revised definitions, updated guidelines, and new CMS reporting requirements aims to save lives through prevention and prompt and effective management of infections. CDC released a new Vital... read more
How nurses support families of ICU patients towards the end of life
Researchers gathered evidence on how nurses care for patients and their families in intensive care when life-sustaining treatment is withdrawn. The included studies explored the care of the family before, during and after... read more
