The Speed of Sound: A New Measure to Single Out High-Risk PE Patients

Predicting which pulmonary embolism patients will do well with oral anticoagulation and which will decompensate is a bit murky, at best. The treatment of pulmonary embolism (PE) has evolved quite a bit in just the past few... read more

The Speed of Sound: A New Measure to Single Out High-Risk PE Patients

Phage Treatment of an Aortic Graft Infected with Pseudomonas Aeruginosa

Another phage therapy success. Bacteria-killing Viruses found in a pond knocked out an antibiotic resistant infection. Management of prosthetic vascular graft infections caused by Pseudomonas aeruginosa can be a significant... read more

Phage Treatment of an Aortic Graft Infected with Pseudomonas Aeruginosa

Survival Benefit of a Low Ratio of Visceral to Subcutaneous Adipose Tissue Depends on LDL Clearance vs. Production in Sepsis

Patients with sepsis with a high ratio of visceral adipose tissue (VAT) to subcutaneous adipose tissue (SAT) have increased mortality. Our goal was to investigate the mechanism of this effect, noting that low LDL levels are... read more

Survival Benefit of a Low Ratio of Visceral to Subcutaneous Adipose Tissue Depends on LDL Clearance vs. Production in Sepsis

Outcomes in Patients with Vasodilatory Shock and RRT Treated with Intravenous Angiotensin II

Acute kidney injury (AKI) requiring renal replacement therapy in severe vasodilatory shock is associated with an unfavorable prognosis. Angiotensin II treatment may help these patients by potentially restoring renal function... read more

Outcomes in Patients with Vasodilatory Shock and RRT Treated with Intravenous Angiotensin II

Critical Burn Patients in the ED/ICU

Dr. Djogovic completed training in Emergency Medicine and Critical Care Medicine from 1999-2005, and is currently employed at the University of Alberta Hospital as an Emergency Physician, and as an Intensivist in the General... read more

Critical Burn Patients in the ED/ICU

Decision-making in the detection and management of patients with sepsis in resource-limited settings

We read with interest the study by Andrews et al. and the related correspondence from Shrestha et al. We share the concern that clinical examination (and observations) appear(s) to be perceived as relatively unimportant in... read more

Decision-making in the detection and management of patients with sepsis in resource-limited settings

Evidence-based Recommendations on the Use of Intravenous Lipid Emulsion Therapy in Poisoning

Although intravenous lipid emulsion (ILE) was first used to treat life-threatening local anesthetic (LA) toxicity, its use has expanded to include both non-local anesthetic (non-LA) poisoning and less severe manifestations... read more

Evidence-based Recommendations on the Use of Intravenous Lipid Emulsion Therapy in Poisoning

Association Between Continuous Hyperosmolar Therapy and Survival in Patients with TBI

Intracranial hypertension (ICH) is a major cause of death after traumatic brain injury (TBI). Continuous hyperosmolar therapy (CHT) has been proposed for the treatment of ICH, but its effectiveness is controversial. We compared... read more

Association Between Continuous Hyperosmolar Therapy and Survival in Patients with TBI

Critical Care Pharmacists and Medication Management in an ICU Recovery Center

Many patients experience complications following critical illness; these are now widely referred to as post-intensive care syndrome (PICS). An interprofessional intensive care unit (ICU) recovery center (ICU-RC), also known... read more

Critical Care Pharmacists and Medication Management in an ICU Recovery Center

Should doctors be required to inform patients of their palliative care rights?

I overheard a colleague admit an 84-year-old woman to the hospital from the emergency department for a sizable mass in her uterus — no doubt, cancerous. I pictured a frail woman who’d been suffering for a while and was... read more

Should doctors be required to inform patients of their palliative care rights?

Are We Using IV Bags Properly?

In the months since Hurricane Maria, my hospital has dealt with an IV bag shortage. It turns out that might not be such a bad thing. Among the collateral damage of Hurricane Maria’s havoc on Puerto Rico is the shutdown... read more

Are We Using IV Bags Properly?

Finding the Best Strategy to Improve Weaning Outcomes

Respiratory muscle dysfunction, being a common cause of weaning failure, is strongly associated with prolonged mechanical ventilation (MV) and prolonged stay in intensive care units. Strategies to improve weaning outcomes... read more

Finding the Best Strategy to Improve Weaning Outcomes

Decision-making on withholding or withdrawing life-support in the ICU

Many critically ill patients who die will do so after a decision has been made to withhold/withdraw life-sustaining therapy. Our objective was to document the characteristics of intensive care unit (ICU) patients with a decision... read more

Decision-making on withholding or withdrawing life-support in the ICU

Cardiac Output Monitoring: Throw it Out… or Keep it?

In critical care units, the shelf for cardiac output (CO) monitoring devices fills up with ever more innovative systems. Are these techniques useful, or are they expensive and irrelevant gadgets? There are arguments to defend... read more

Cardiac Output Monitoring: Throw it Out… or Keep it?

REPROVE: Ceftazidime-avibactam Noninferior to Meropenem for Nosocomial Pneumonia

Ceftazidime-avibactam was noninferior to meropenem for nosocomial pneumonia including ventilator-associated pneumonia (VAP) from gram-negative organisms, results from the REPROVE trial demonstrated. Nosocomial or hospital-acquired... read more

REPROVE: Ceftazidime-avibactam Noninferior to Meropenem for Nosocomial Pneumonia

Sepsis Incidence: A Population-Based Study

The incidence of sepsis with organ dysfunction is higher than most previous estimates independent of definition. The inclusion of all inpatients started on intravenous antibiotic treatment of sepsis in a population makes... read more

Sepsis Incidence: A Population-Based Study

FDA Approves Treatment of Patients with Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia

FDA has approved Allergan's supplemental New Drug Application (sNDA) to expand the approved use of AVYCAZ® (ceftazidime and avibactam) to include the treatment of hospital-acquired bacterial pneumonia and ventilator-associated... read more

FDA Approves Treatment of Patients with Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia