Doctor Turns Up Possible Treatment For Deadly Sepsis

Doctor Turns Up Possible Treatment For Deadly Sepsis

It is hard not to get excited about news of a potentially effective treatment for sepsis, a condition that leads to multiple organ failure and kills more people in the hospital than any other disease. The study, from Eastern... read more

What’s new in the extracorporeal treatment of sepsis?

Clinical research has shown that endotoxin is indeed circulating in the blood of up to 50% of sepsis shock patients and associated with impaired clinical outcome. In view of the pivotal role of endotoxin in sepsis patients,... read more

The ICM research agenda on ICU-acquired weakness

The ICM research agenda on ICU-acquired weakness

Intensive care unit (ICU)-acquired weakness (ICUAW) develops as a complication of critical illness and may represent the extreme end of a spectrum of weakness that begins with any serious illness regardless of care location.... read more

Decision Making Model Enables Resolution of Ethics Issues at the Bedside

Decision Making Model Enables Resolution of Ethics Issues at the Bedside

A study from Switzerland that evaluated implementation of a stepped ethical decision-making model on three intensive care units (ICUs) and two geriatric wards found that it worked well, with staff able to find the time and... read more

Delirium in Critically Ill Children: An International Point Prevalence Study

Delirium in Critically Ill Children: An International Point Prevalence Study

In this multi-institutional, multinational point prevalence study of 994 subjects, delirium screening by the bedside nurse was feasible in children of all ages. PD was a common complication of critical illness, with a prevalence... read more

Never Stop Caring

Never Stop Caring

I read with interest the piece by Wilson et al regarding their examination of end-of-life care patterns in hospitalized patients on their vascular surgery practice in Oregon. I applaud the authors for examining their practices... read more

Role of Combination Antimicrobial Therapy for Vancomycin‐Resistant Enterococcus faecium Infections

Role of Combination Antimicrobial Therapy for Vancomycin‐Resistant Enterococcus faecium Infections

Enterococcus species are the second most common cause of nosocomial infections in the United States and are particularly concerning in critically ill patients with preexisting comorbid conditions. Rising resistance to antimicrobials... read more

Care that Matters: Quality Measurement and Health Care

Care that Matters: Quality Measurement and Health Care

Barry Saver and colleagues caution against the use of process and performance metrics as health care quality measures in the United States. There is limited evidence that many "quality" measures - including those... read more

Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin

Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin

Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischaemic attack of atherosclerotic origin: a subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. In this prespecified... read more

Multifaceted educational intervention shortened time to antibiotic administration in children with sepsis

Multifaceted educational intervention shortened time to antibiotic administration in children with sepsis

A multifaceted educational intervention shortened time to antibiotic administration in children with severe sepsis and septic shock: ABISS Edusepsis pediatric study. The Surviving Sepsis Campaign (SSC) recommends the administration... read more

Addressing Physician Burnout

Addressing Physician Burnout

The US health care delivery system and the field of medicine have experienced tremendous change over the last decade. At the system level, narrowing of insurance networks, employed physicians, and financial pressures have... read more

Cholesteryl Ester Crystals in Lysosomal Acid Lipase Deficiency

Cholesteryl Ester Crystals in Lysosomal Acid Lipase Deficiency

Deficiency of lysosomal acid lipase is a rare autosomal recessive lysosomal storage disease characterized by the accumulation of cholesteryl esters and triglycerides, predominantly in macrophages. Nonspecific clinical features... read more

Influenza and Considerations Regarding Infectious Mimics

Influenza and Considerations Regarding Infectious Mimics

The patient with headache, myalgia, and URI symptoms may just have the common flu. It's all too common to see and treat multiple patients with influenza-like illness during the flu season. But what could you be missing?... read more

Palliative care from diagnosis to death

Palliative care from diagnosis to death

Evidence is growing that people can benefit from palliative care earlier in their illness, say Scott Murray and colleagues, but care must be tailored to different conditions. Many people still associate palliative care with... read more

Electronic Dura Mater Meddling in the Central Nervous System

Electronic Dura Mater Meddling in the Central Nervous System

This review of preclinical applications assesses the potential of the electronic dura mater to deliver electrical and chemical stimulation to targeted areas of the central nervous system for extended periods. Soft neural... read more

GERD Treatment May Reduce Healthcare Visits for Acute Respiratory Infections

GERD Treatment May Reduce Healthcare Visits for Acute Respiratory Infections

Treatment with proton pump inhibitors (PPIs) may help decrease healthcare visits for acute respiratory infections (ARIs) in patients with gastroesophageal reflux disease (GERD). These are the findings of a new study published... read more

Fecal microbiota transplantation a decolonization treatment option

Fecal microbiota transplantation a decolonization treatment option

The use of fecal microbiota transplantation is an option to eradicate highly drug-resistant enteric bacteria carriage, according to results from a small pilot study conducted by French investigators. A prospective study of... read more