Non-antibiotic treatments for bacterial diseases in an antibiotic resistance era

Non-antibiotic treatments for bacterial diseases in an antibiotic resistance era

The progressive spread of antibiotic resistance genes is forcing us to reconsider our treatment options against some bacterial pathogens. Treating bacterial infections will likely become more challenging in the future. We... read more

Upright CT for lung cancer therapy planning used at Chicago Proton Center

Upright CT for lung cancer therapy planning used at Chicago Proton Center

The Northwestern Medicine Chicago Proton Center will be the first proton center in the U.S. to use P-Cure new P-ARTIS CT on patients being treated for lung cancer. Traditionally, patients lie flat on their backs during CT... read more

Reducing Natalizumab Concentration May Reduce PML Risk

Reducing Natalizumab Concentration May Reduce PML Risk

Serum concentrations of natalizumab do not appear to rise before patients with relapsing-remitting multiple sclerosis are diagnosed with progressive multifocal leukoencephalopathy, contradicting the hypothesis that exposure... read more

Cooling patients with TBI improve survival chances

Cooling patients with TBI improve survival chances

New research from Royal Holloway published today in Critical Care Medicine shows that lowering the body temperature of people who have suffered a traumatic brain injury (TBI) as soon as possible after the trauma may significantly... read more

Plazomicin Succeeds in Phase 3 cUTI and CRE Trial

Plazomicin Succeeds in Phase 3 cUTI and CRE Trial

Plazomicin an antibiotic being developed to fight multidrug-resistant bacterial infections, has met the primary objective of noninferiority compared with meropenem in a phase 3 registration trial among patients with complicated... read more

Glutamine, fish oil and antioxidants in critical illness

Glutamine, fish oil and antioxidants in critical illness

We hypothesize that the harmful effect of IMHP compared to HP enteral nutrition in a heterogeneous group of critically ill patients is limited to the medical critically ill patients and mediated by an early increase in (epa... read more

Non-invasive Respiratory Support and Methylxanthines Reduce Re-Intubations

Non-invasive Respiratory Support and Methylxanthines Reduce Re-Intubations

In a meta-analysis of randomized studies evaluating efforts to reduce re-intubations and respiratory failure in preterm infants, non-invasive respiratory support and use of methylxanthines (theophylline, caffeine) were found... read more

The role of POC Diagnostics in Combatting Antibiotic Resistance

The role of POC Diagnostics in Combatting Antibiotic Resistance

During the winter months, patients frequently present with respiratory symptoms like coughing, sneezing and fever that could be caused by one of several bacterial and viral infections including influenza, respiratory syncytial... read more

Randomised trials role in surgery

Randomised trials role in surgery

In medical science, as in all walks of life, we are impressed by dramatic effects.  If a new treatment seems much better than an old one initially, there is often impatience to get on and use it, and people question why... read more

RSNA attendees warned by FBI about the threat of radiation theft from hospitals

RSNA attendees warned by FBI about the threat of radiation theft from hospitals

FBI and Department of Energy reps briefed a room full of RSNA attendees in Chicago last week about a growing litany of concerns ranging from disgruntled medical employees stealing radioactive materials, to patients setting... read more

Antibiotic therapy advances in the critically ill

Antibiotic therapy advances in the critically ill

Key issues related to antibiotic management in the critically ill, including problems associated with timing, duration, and dosing of antibiotics. The authors highlighted the importance of early diagnosis of infection and... read more

Testosterone VTE Risk; Novel Clot Buster Flops Again; Saturated Fat Culpability

Testosterone VTE Risk; Novel Clot Buster Flops Again; Saturated Fat Culpability

The venous thromboembolism (VTE) risk warned about with testosterone treatment appears to be transient, peaking within 6 months after starting and then gradually declining.... read more

Pulmaquin Looks Promising for Treating Lung Infections in Non-CF Bronchiectasis Patients

Pulmaquin Looks Promising for Treating Lung Infections in Non-CF Bronchiectasis Patients

Aradigm has announced top-line results from two Phase 3 clinical trials of Pulmaquin (inhaled ciprofloxacin) for the treatment of patients with non-cystic fibrosis bronchiectasis (non-CF BE) who have chronic lung infections... read more

Gut microbes promote motor deficits in a mouse model of Parkinson’s disease

Gut microbes promote motor deficits in a mouse model of Parkinson’s disease

Gut microbes may play a critical role in the development of Parkinson's-like movement disorders in genetically predisposed mice, researchers report.... read more

Scientists create first viable mathematical model of a key anti-Salmonella defense system

Scientists create first viable mathematical model of a key anti-Salmonella defense system

Scientists have created the first validated mathematical model of an important cellular defense mechanism against the bacterium Salmonella, according to a new study in PLOS Computational Biology.... read more

USPSTF: Don’t Screen Asymptomatic Adults for Thyroid Cancer

USPSTF: Don’t Screen Asymptomatic Adults for Thyroid Cancer

After reviewing studies on the benefits and harms of screening and treatment for thyroid cancer, a newly released U.S. Preventive Services Task Force draft statement recommends against screening asymptomatic adults for the... read more

New anti-inflammatory drug reduces death of existing brain cells then repairs damage after stroke

New anti-inflammatory drug reduces death of existing brain cells then repairs damage after stroke

Researchers at The University of Manchester have discovered that a potential new drug reduces the number of brain cells destroyed by stroke and then helps to repair the damage.... read more