Tag: trial
Dual Therapy Using Sildenafil and Milrinone Superior to Monotherapy in Neonates with Severe PPHN
Dual therapy using sildenafil and milrinone was superior to monotherapy with either drug in neonates with severe persistent pulmonary hypertension (PPHN) and is recommended for use in resource-constrained settings. A double-blind... read more
Thrombotic and Hemorrhagic Complications in Critically Ill Patients with COVID-19
Critically ill patients with COVID-19 experience high rates of venous and arterial thrombotic complications. The rates of bleeding may be higher than previously reported and re-iterate the need for randomised trials to better... read more
ECMO During the Coronavirus Disease 2019 Pandemic
In the midst of the 2009 influenza A H1N1 pandemic, clinicians turned to extracorporeal membrane oxygenation (ECMO) as a strategy to save lives. Based on the H1N1 experience, and the ECMO to Rescue Lung Injury in Severe... read more
Quality of Life of Intensive Care Unit-Acquired Weakness Symptoms in Long-Term Intensive Care Survivors
Intensive care unit-acquired weakness (ICUAW) symptoms were disturbingly common in the majority of long-term survivors, indicating that symptoms persist up to 10y and frequently impair QoL. However, only a small number of... read more
From Russia with Love – “Sputnik V” COVID-19 Vaccine Generated an Immune Response
Between June 18 and Aug 3, 2020, Ministry of Health of the Russian Federation enrolled 76 participants to the two studies (38 in each study). In each study, 9 volunteers received rAd26-S in Phase 1, nine received rAd5-S in... read more
COVID-19: A Critical Analysis of Chloroquine and Hydroxychloroquine Clinical Pharmacology
Chloroquine and hydroxychloroquine have been used for over 60 years in the treatment of malaria, amoebic liver abscess, and several rheumatological conditions, but their clinical pharmacology is not well understood. COVID-19... read more
Hydroxychloroquine With or Without Azithromycin
Among patients hospitalized with mild-to-moderate COVID-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. A total of 667 patients... read more
Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19
Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority... read more
Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure
Among patients receiving recommended therapy for heart failure, those in the empagliflozin group had a lower risk of cardiovascular death or hospitalization for heart failure than those in the placebo group, regardless of... read more
Shorter Resident Shifts May Not Improve Patient Safety
Residents who worked schedules that eliminated extended shifts made a greater number of serious errors than those who worked schedules with shifts of 24 or more hours, a trial in the New England Journal of Medicine reported. The... read more
Awake Prone Positioning for COVID-19 Hypoxemic Respiratory Failure
Infection with SARS-CoV-2 can result in Coronavirus Disease–19 (COVID-19). While the majority of patients are asymptomatic or have mild disease, approximately 14% develop more severe disease including hypoxemic respiratory... read more
Artificial Neural Networks Improve Prediction and Risk Classification in ICU Patients
A supervised machine learning model using artificial neural networks (ANN) predicted neurological recovery, including survival excellently, and outperformed a conventional model based on logistic regression. Among the data... read more
Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol in ICU
Approaches to removal of sedation and mechanical ventilation for critically ill patients vary widely. Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)—ie, daily interruption of sedatives—with... read more
Automated vs. Conventional Ventilation in the ICU
Automated ventilation (AV) appears to reduce the incidence and severity of blood oxygen desaturation during daily nursing procedures (DNPs) in comparison to Conventional Ventilation (CV). Of the 265 included patients,... read more
Comparing Procedural Amnesia and Respiratory Depression vs. MS and DS with Propofol
Targeting moderate sedation (MS) or deep sedation (DS) did not reliably result in the intended sedation level. Targeting MS, however, resulted in a lower rate of total AREs and fewer patients had multiple AREs with no difference... read more
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and ARDS
In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.... read more
Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status
Moderate to severe anxiety at ICU admission is associated with early occurrence of new organ failure in critically ill patients, independently of respiratory status and severity of critical illness. The causality link could... read more
Substituting Acetaminophen for Fentanyl Feasible in PCI for STEMI
In patients with STEMI given crushed ticagrelor before PCI, using IV acetaminophen instead of IV fentanyl as a painkiller did not increase pain levels or platelet reactivity and prevented delay of ticagrelor's effects, researchers... read more
