Tag: trial
Instrumental Activities of Daily Living Related to ARDS Survivors’ Quality of Life
Instrumental Activities of Daily Living (IADL), not body functions & structures measures, are related to ARDS survivors' quality of life and should be included in future studies. Bringing greater consistency to outcomes... read more
Impact of Protocolized Diuresis for De-resuscitation in the ICU
Using a diuresis protocol for volume de-resuscitation, we demonstrated a significant decrease in net cumulative fluid balance at 72 h following shock resolution, with potential benefit on clinical outcomes including renal... read more
Effect of Vitamin C and Thiamine on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock
A 2020 randomized trial reported no difference in duration of time alive and free of vasopressor administration at 7 days among intensive care unit (ICU) patients with septic shock assigned to vitamin C, thiamine, and hydrocortisone... read more
eFAST Performance with a Novel vs. Conventional Transducers
Point-of-injury extended focused assessment with sonography in trauma (eFAST) may identify life-threatening torso hemorrhage and expedite casualty evacuation. The purpose of this study was to compare combat medic eFAST performance... read more
Pretreating Transfused Erythrocytes with NO Prevents Pulmonary Hypertension
Researchers at Massachusetts General Hospital (MGH; Boston, USA), Harvard Medical School (HMS; Boston, MA, USA), and other institutions conducted a trial to see if treating stored packed sheep RBCs with NO before transfusion... read more
Could Stress Ulcer Prophylaxis Increase Mortality in High-acuity Patients?
Although considerable uncertainty remains, the inferences from SUP-ICU and PEPTIC are consistent with the hypothesis that proton pump inhibitors (PPIs) increase the risk of death in patients with higher illness severity.... read more
It’s Insane to Keep Using Mortality As a Primary Endpoint in Critical Care Trials
Mortality is an important endpoint, so we shouldn't ignore mortality trends entirely. However, the vast majority of these will be spurious. Thus, we should generally not change practice due to them. In the history of critical... read more
Tranexamic Acid in TBI – CRASH-3 Trial Treatment
The CRASH-3 trial is a multi-centre, randomised, placebo-controlled trial of the effects of tranexamic acid on death and disability in patients with traumatic brain injury (TBI). Patients with reactive pupils and/or mild... read more
Potential Therapy for Improving Sudden Cardiac Arrest Resuscitation Outcomes
The severity of cardiogenic shock following asystolic cardiac arrest is dependent on the length of cardiac arrest prior to cardiopulmonary resuscitation and is mediated by myocardial stunning resulting from mitochondrial... read more
Should We Treat Fever in Critically Ill Patients Without Acute Brain Pathology?
In one of the sessions at #LIVES2019 in Berlin, Prof. Frank Van Haren of Canberra Hospital, Australia, presented findings from the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management... read more
Management of Cardiogenic Shock Complicating Myocardial Infarction – 2019 Update
In general, randomized clinical trials in CS are difficult to perform and only three randomized trials adequately powered to detect differences in clinical outcomes achieved completion of the required number of patients. Based... read more
Health Coaching to Increase Appropriate Inhaler Use in COPD
Health coaching may provide a scalable model that can improve care for people living with chronic obstructive pulmonary disease (COPD). Baseline adherence and inhaler technique were uniformly poor and did not differ by... read more
Glucose Variability as Measured by Inter-measurement Percentage Change is Predictive of In-patient Mortality in Aneurysmal Subarachnoid Hemorrhage
Reduced glucose variability is highly correlated with in-patient survival and long-term mortality in subarachnoid hemorrhage (aSAH) patients. This finding was observed in the non-diabetic and well-controlled diabetic patients,... read more
Prone Positioning Monitored by Electrical Impedance Tomography in Patients with Severe ARDS on VV-ECMO
Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), the impact of... read more
