Tag: trial
Prehospital Antibiotics in the Ambulance for Sepsis
Emergency medical services (EMS) personnel have already made substantial contributions to improving care for patients with time-dependent illnesses, such as trauma and myocardial infarction. Patients with sepsis could also... read more
Effect of Procalcitonin-guided Antibiotic Treatment on Mortality in Acute Respiratory Infections
Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infections reduces antibiotic exposure and side-effects, and improves survival. Widespread implementation of procalcitonin protocols in... read more
Critical Care Cycling Study (CYCLIST) Trial Protocol
Critical Care Cycling Study (CYCLIST) trial protocol: a randomised controlled trial of usual care plus additional in-bed cycling sessions versus usual care in the critically ill. In-bed cycling with patients with critical... read more
Lowering systolic blood pressure would save more than 100,000 lives per year, study finds
Intensive treatment to lower systolic (top number) blood pressure to below 120 would save more than 100,000 lives per year in the United States, say scientists. Two thirds of the lives saved would be men and two thirds would... read more
Early Exercise in Critically Ill Youth and Children, a Preliminary Evaluation
Early mobilization is safe and feasible in the PICU. In-bed cycling may facilitate greater duration and intensity of mobilization, in critically ill children. A full-scale randomized controlled trial is warranted to evaluate... read more
The Septic Shock 3.0 Definition and Trials
Ranjit Deshpande, MD, speaks with James A. Russell, MD, about the article, "The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience," published in the June 2017 issue of Critical Care Medicine.... read more
Does a 1-h Rest After a Successful SBT Really Improve Extubation Outcome?
Discussion on whether reconnection to mechanical ventilation for 1h after a successful spontaneous breathing trial (SBT) reduces reintubation in critically ill patients: a multicenter randomized controlled trial.... read more
Can we stop worrying about the age of blood?
Blood transfusions are common in critically ill patients; two in five adults admitted to an ICU receive at least one transfusion during their hospitalization. Recently, there has been growing concern about the potential dangers... read more
Enteral vs. Parenteral Early Nutrition in Ventilated Adults with Shock
In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocaloric... read more
Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe hemorrhage
Antifibrinolytics reduce death from bleeding in trauma and post-partum haemorrhage. We examined the effect of treatment delay on the effectiveness of antifibrinolytics. We obtained data for 40,138 patients from two randomised... read more
Shock Trauma to Study Body Cooling for Patients in Cardiac Arrest from Massive Bleeding
The R Adams Cowley Shock Trauma Center at the University of Maryland has opened a clinical trial to study whether rapidly cooling the body temperature of patients whose hearts stop due to massive blood loss will give surgeons... read more
Assessing Usefulness of Randomized Clinical Trials
In the pyramid of evidence based medicine randomized controlled trials (RCTs) are considered to be one of the most reliable study designs when evaluating the cause and effect of treatment modalities. When evaluating randomized... read more
Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold
Long-term mortality rates and HRQoL did not differ in patients with septic shock and anaemia who were transfused at a haemoglobin threshold of 7 g/dl versus a threshold of 9 g/dl. We may reject a more than 3 % increased hazard... read more
Does Early Mobilization Reduce Time in the Surgical ICU?
Is early mobilization in the surgical intensive care unit (ICU) beneficial? Here is a multicenter, randomized, controlled trial in five university hospitals, where they recruited a total of 200 patients.... read more
Immunoglobulin G for patients with Necrotising Soft Tissue Infection
The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported physical function in intensive care unit (ICU) patients with necrotising soft... read more
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults
Between Feb 6, 2014, and June 26, 2016, 1360 patients were assessed, and 672 were randomly assigned, with 222 in the placebo group, 227 in the 0·5 mg/kg ketamine group, and 223 in the 1·0 mg/kg ketamine group. There was... read more
A multicenter, randomized trial of a checklist for endotracheal intubation of critically ill adults
The verbal performance of a written, pre-procedure checklist does not increase the lowest arterial oxygen saturation or lowest systolic blood pressure during endotracheal intubation of critically ill adults compared to usual... read more
Cellular Immunotherapy for Septic Shock
The infusion of freshly cultured allogenic bone marrow derived MSCs into participants with septic shock up to a dose of 3 million cells per kg (250 million cells) appears safe. Ages of participants in the interventional versus... read more
Therapeutic Interchange of Clevidipine For Sodium Nitroprusside in Cardiac Surgery
Sodium nitroprusside (SNP) has been used clinically for decades for the treatment of hypertension associated with cardiac surgery.... read more
Can Early Rehabilitation on the General Ward After an ICU Stay Reduce Hospital Length of Stay in Survivors of Critical Illness?
An early rehabilitation program in survivors of critical illness led to an earlier discharge from the hospital, improved functional recovery, and was also cost-effective and safe. In the per-protocol analysis, length of... read more
Causes for Pauses During Simulated Pediatric Cardiac Arrest
Pauses in cardiopulmonary resuscitation occurred frequently during simulated pediatric cardiac arrest, with variable duration and underlying causes. A large percentage of pauses were greater than 10 seconds and occurred more... read more
