Tag: trial
Shock Trauma to Study Body Cooling for Patients in Cardiac Arrest from Massive Bleeding
The R Adams Cowley Shock Trauma Center at the University of Maryland has opened a clinical trial to study whether rapidly cooling the body temperature of patients whose hearts stop due to massive blood loss will give surgeons... read more
Assessing Usefulness of Randomized Clinical Trials
In the pyramid of evidence based medicine randomized controlled trials (RCTs) are considered to be one of the most reliable study designs when evaluating the cause and effect of treatment modalities. When evaluating randomized... read more
Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold
Long-term mortality rates and HRQoL did not differ in patients with septic shock and anaemia who were transfused at a haemoglobin threshold of 7 g/dl versus a threshold of 9 g/dl. We may reject a more than 3 % increased hazard... read more
Does Early Mobilization Reduce Time in the Surgical ICU?
Is early mobilization in the surgical intensive care unit (ICU) beneficial? Here is a multicenter, randomized, controlled trial in five university hospitals, where they recruited a total of 200 patients.... read more
Immunoglobulin G for patients with Necrotising Soft Tissue Infection
The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported physical function in intensive care unit (ICU) patients with necrotising soft... read more
Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults
Between Feb 6, 2014, and June 26, 2016, 1360 patients were assessed, and 672 were randomly assigned, with 222 in the placebo group, 227 in the 0·5 mg/kg ketamine group, and 223 in the 1·0 mg/kg ketamine group. There was... read more
A multicenter, randomized trial of a checklist for endotracheal intubation of critically ill adults
The verbal performance of a written, pre-procedure checklist does not increase the lowest arterial oxygen saturation or lowest systolic blood pressure during endotracheal intubation of critically ill adults compared to usual... read more
Cellular Immunotherapy for Septic Shock
The infusion of freshly cultured allogenic bone marrow derived MSCs into participants with septic shock up to a dose of 3 million cells per kg (250 million cells) appears safe. Ages of participants in the interventional versus... read more
Therapeutic Interchange of Clevidipine For Sodium Nitroprusside in Cardiac Surgery
Sodium nitroprusside (SNP) has been used clinically for decades for the treatment of hypertension associated with cardiac surgery.... read more
Can Early Rehabilitation on the General Ward After an ICU Stay Reduce Hospital Length of Stay in Survivors of Critical Illness?
An early rehabilitation program in survivors of critical illness led to an earlier discharge from the hospital, improved functional recovery, and was also cost-effective and safe. In the per-protocol analysis, length of... read more
Causes for Pauses During Simulated Pediatric Cardiac Arrest
Pauses in cardiopulmonary resuscitation occurred frequently during simulated pediatric cardiac arrest, with variable duration and underlying causes. A large percentage of pauses were greater than 10 seconds and occurred more... read more
Restricting volumes of resuscitation fluid in adults with septic shock after initial management
A protocol restricting resuscitation fluid successfully reduced volumes of resuscitation fluid compared with a standard care protocol in adult ICU patients with septic shock.... read more
Selepressin – An Effective Substitute for Norepinephrine
Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Vasopressin is widely used for vasopressor... read more
Controlled Trial to Improve Resident Sign-out in a Medical ICU
Poor sign-out or handover of care may lead to preventable patient harm. Critically ill patients in intensive care units (ICU) are complex and prone to rapid clinical deterioration. If clinical deterioration occurs, timeliness... read more
Whole Body Hyperthermia Appeared to Reduce Depression Symptoms
Whole-body hyperthermia holds promise as a safe, rapid-acting, antidepressant modality with a prolonged therapeutic benefit. Results from the current study suggest that WBH holds promise as a safe, rapid-acting, antidepressant... read more
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
EBUS-TBNA is a safe procedure. The highest complication rate reported is 1.44%. Additionally, the scope damage could be encountered in 1.33% of cases and occasionally the TBNA needle could malfunction. The complications are... read more
External validation of a biomarker and clinical prediction model for hospital mortality in ARDS
Mortality prediction in ARDS is important for prognostication and risk stratification. However, no prediction models have been independently validated. We validated a mortality prediction model for ARDS that includes age,... read more
Stress Ulcer Prophylaxis in the ICU (SUP-ICU)
Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported. The aim of the SUP-ICU trial is to asses the overall... read more
This Startup Could Revolutionize How We Fight Infectious Diseases
Karius Test has raised $50 million to develop a novel technology that can detect more than 1,000 infectious diseases, without requiring the usual trial-and-error tests. The test is expensive at $2,000, and is meant for use... read more
External Validity of Electronic Sniffers for Automated Recognition of ARDS
Automated electronic sniffers may be useful for early detection of acute respiratory distress syndrome (ARDS) for institution of treatment or clinical trial screening. Published electronic sniffer algorithms for ARDS may... read more
Effect of Obstructive Sleep Apnea Treatment on Renal Function in Patients with Cardiovascular Disease
Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. Objectives: To determine the effects of continuous positive airway... read more
Direct Oral Anticoagulant- or Warfarin-Related Major Bleeding
Direct oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin... read more
