Tag: vasoplegia

Beyond the Pressure: Moving Toward Personalized Sepsis Care

In the high-stakes environment of septic shock, the current clinical "gold standard" remains the early initiation of norepinephrine. However, when blood pressure targets aren't met, the next steps often become a pragmatic... read more

Vasopressin in Septic Shock: When and How to Use the Second-Line Vasopressor

SSC Guideline Recommendation: The Surviving Sepsis Campaign (SSC) weakly recommends adding vasopressin as a second-line agent instead of continuously escalating norepinephrine if a patient's mean arterial pressure (MAP) remains... read more

Improving Hemodynamics in Vasoplegia Septic Shock with Adjunctive Tocilizumab

In pediatric patients with vasoplegia septic shock, adjunctive tocilizumab is associated with improved hemodynamics, shortened shock duration, and reduced mortality. IL-6 may serve as both a biomarker and therapeutic target... read more

Hydroxocobalamin Treatment for Vasoplegia-associated Shock

Vasoplegia is generally defined as prolonged vasodilation due to a pathological decrease in systemic vascular resistance, which causes persistent hypotension even in the setting of normal or increased cardiac output. Vasoplegia... read more